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Human CAAF1 gene--molecular cloning, gene structure, and chromosome mapping.

Abstract：

:We have isolated and characterized a cDNA and the gene of the human homologue of CAAF1, a novel member of the S100 calcium-binding protein family. The 276-bp open reading frame encoded a 92-amino acid polypeptide with a predicted molecular mass of 10,575 Da. The deduced amino acid sequence of human CAAF1 showed 66% homology to bovine CAAF1. The human CAAF1 gene consisted of three exons, with the two EF hand motifs of the CAAF1 protein separately encoded by exons 2 and 3. This gene was expressed at a high level in polymorphonuclear leukocytes and at an intermediate level in esophageal mucosa. The tissue distribution of CAAF1 mRNA was different from that of other S100 proteins. Direct R-banding fluorescence in situ hybridization revealed that the human CAAF1 gene was mapped to chromosome 1q21.2-q22, where most of the S100 genes form a cluster.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yamamura T,Hitomi J,Nagasaki K,Suzuki M,Takahashi E,Saito S,Tsukada T,Yamaguchi K

doi

10.1006/bbrc.1996.0600

subject

Has Abstract

pub_date

1996-04-16 00:00:00

pages

356-60

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X96906002

journal_volume

221

pub_type

杂志文章

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