当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Epithelial Na+ channel and ion transport in human nasal polyp and paranasal sinus mucosa.

Epithelial Na+ channel and ion transport in human nasal polyp and paranasal sinus mucosa.

Abstract：

:The purpose of the present study is to characterize the ENaC-mediated Na+ absorption in human upper airway epithelia, nasal cavity, and paranasal sinus. To perform the purpose, we obtained epithelial cells from human nasal polyp (NP) and paranasal sinus mucosa (PSM) by endoscopic surgery. We measured the short-circuit current (I(sc)) sensitive to benzamil (a specific ENaC blocker). The benzamil-sensitive I(sc) (Na+ absorption) in NP was larger than that in PSM. The mRNA expression of three subunits of ENaC was as follows: alpha>beta>gamma in both tissue, NP and MS. The mRNA expression of gamma subunit of ENaC in NP was larger than that in PSM, but no difference of mRNA expression of alpha or beta ENaC subunit between NP and PSM was detected. We found correlation of the Na+ absorption to mRNA expression of gamma ENaC in NP and PSM. Forskolin diminished the Na+ absorption associated with an increase in Cl- secretion. These observations suggest that: (1) human NP absorbs more ENaC-mediated Na+ than PSM, (2) expression of gamma ENaC in plays a key role in the ENaC-mediated Na+ absorption in NP and PSM, and (3) cAMP diminishes the ENaC-mediated Na+ absorption by stimulating Cl- secretion (diminution of driving force for Na+ absorption) in NP and PSM.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yasuda M,Niisato N,Miyazaki H,Iwasaki Y,Hama T,Dejima K,Hisa Y,Marunaka Y

doi

10.1016/j.bbrc.2007.08.065

subject

Has Abstract

pub_date

2007-10-26 00:00:00

pages

753-8

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)01768-8

journal_volume

362

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Effect of interleukin-6 on cell proliferation of FRTL-5 cells.

    abstract：:We studied the effects of interleukin-6(IL-6) on DNA synthesis and cyclic AMP production in rat thyroid FRTL-5 cells. When cells were incubated with IL-6 in the presence or absence of IGF-I, cell proliferation was not observed. By contrast, IL-6 stimulated DNA synthesis in a dose dependent manner when TSH was added co...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1416

    authors： Nishiyama S,Takada K,Tada H,Takano T,Amino N

    更新日期：1993-04-15 00:00:00

  • Conjugal transfer of plasmid and transposon DNA from Escherichia coli into Porphyromonas gingivalis.

    abstract：:Using the broad host-range vector R751 to provide transfer functions, plasmid pVAL-1 and transposon Tn4351 were conjugally mobilized from Escherichia coli into Porphyromonas gingivalis. Transfer frequencies for both elements varied between 10(-6) and 10(-11), depending upon the recipient. The behavior of pVAL-1 and Tn...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)90847-e

    authors： Dyer DW,Bilalis G,Michel JH,Malek R

    更新日期：1992-07-31 00:00:00

  • Helicobacter pylori-derived Heat shock protein 60 enhances angiogenesis via a CXCR2-mediated signaling pathway.

    abstract：:Helicobacter pylori is a potent carcinogen associated with gastric cancer malignancy. Recently, H. pylori Heat shock protein 60 (HpHSP60) has been reported to promote cancer development by inducing chronic inflammation and promoting tumor cell migration. This study demonstrates a role for HpHSP60 in angiogenesis, a ne...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.05.101

    authors： Lin CS,He PJ,Hsu WT,Wu MS,Wu CJ,Shen HW,Hwang CH,Lai YK,Tsai NM,Liao KW

    更新日期：2010-06-25 00:00:00

  • Molecular cloning, expression, and functional characterization of a novel zebrafish cytosolic sulfotransferase.

    abstract：:By searching the zebrafish expressed sequence tag (EST) database, we have identified a cDNA clone encoding a putative zebrafish cytosolic sulfotransferase (ST). This cDNA was isolated and subjected to nucleotide sequencing. Analysis of the sequence data revealed that this novel zebrafish ST displays 32-35% amino acid ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)02915-7

    authors： Sugahara T,Liu CC,Govind Pai T,Liu MC

    更新日期：2003-01-17 00:00:00

  • Purification and properties of 4-hydroxyphenylacetic acid 3-hydroxylase from Pseudomonas putida.

    abstract：:4-Hydroxyphenylacetic acid 3-hydroxylase is a key enzyme in the pathway for the microbial degradation of phenylalanine, tyrosine and many aromatic amines. This enzyme was purified to homogeneity from Pseudomonas putida by affinity chromatography. The protein had a molecular weight of 91,000 and was a dimer of identica...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(88)90173-8

    authors： Raju SG,Kamath AV,Vaidyanathan CS

    更新日期：1988-07-29 00:00:00

  • Rapid delivery of small interfering RNA by biosurfactant MEL-A-containing liposomes.

    abstract：:The downregulation of gene expression by RNA interference holds great potential for genetic analysis and gene therapy. However, a more efficient delivery system for small interfering RNA (siRNA) into the target cells is required for wide fields such as cell biology, physiology, and clinical application. Non-viral vect...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.09.147

    authors： Inoh Y,Furuno T,Hirashima N,Kitamoto D,Nakanishi M

    更新日期：2011-10-28 00:00:00

  • Stimulatory effect of endogenous tissue inhibitor of metalloproteinases-1 (TIMP-1) overexpression on type IV collagen and laminin gene expression in rat mammary carcinoma cells.

    abstract：:We recently reported enhanced tumor growth and stimulation of vascular endothelial growth factor (VEGF) expression in rat mammary carcinoma cells transfected with a human tissue inhibitor of metalloproteinases-1 (hTIMP-1) cDNA (1). In the present study, we examined if the composition of the stroma was altered in the t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8805

    authors： Yoshiji H,Buck TB,Harris SR,Ritter LM,Lindsay CK,Thorgeirsson UP

    更新日期：1998-06-29 00:00:00

  • Cold stress accentuates pressure overload-induced cardiac hypertrophy and contractile dysfunction: role of TRPV1/AMPK-mediated autophagy.

    abstract：:Severe cold exposure and pressure overload are both known to prompt oxidative stress and pathological alterations in the heart although the interplay between the two remains elusive. Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel activated in response to a variety of exogenous and en...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.10.128

    authors： Lu S,Xu D

    更新日期：2013-12-06 00:00:00

  • K-rasG12V mediated lung tumor models identified three new quantitative trait loci modifying events post-K-ras mutation.

    abstract：:A high incidence of oncogenic K-ras mutations is observed in lung adenocarcinoma of human cases and carcinogen-induced animal models. The process of oncogenic K-ras-mediated lung adenocarcinogenesis can be dissected into two parts: pre- and post-K-ras mutation. Adoption of transgenic lines containing a flox-K-rasG12V ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.09.052

    authors： Saito H,Suzuki N

    更新日期：2014-10-03 00:00:00

  • Identification of a novel positive regulator of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli.

    abstract：:The hpa cluster of Escherichia coli W ATCC 11105 encodes the enzymes involved in the catabolism of 4-hydroxyphenylacetate (4-HPA). The catabolic genes are organized in two operons, the hpaBC operon, which produces the hydroxylase activity, and the meta operon, which encodes the enzymes that cleave the aromatic ring an...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6368

    authors： Prieto MA,García JL

    更新日期：1997-03-27 00:00:00

  • p56lck phosphorylation by Ca2+/calmodulin-dependent protein kinase type II.

    abstract：:Ca2+/calmodulin-dependent protein kinases are implicated in regulating the Ca2+ signaling involved in T cell activation and in thymocyte selection. One of the earliest events in signaling through the T cell antigen receptor is activation of the protein tyrosine kinase p56lck. Following T cell activation or signaling t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.1010

    authors： Bland MM,McDonald OB,Carrera AC

    更新日期：1994-01-14 00:00:00

  • A role for Rab5 activity in the biogenesis of endosomal and lysosomal compartments.

    abstract：:Rab5 is a small GTPase that plays roles in the homotypic fusion of early endosomes and regulation of intracellular vesicle transport. We show here that expression of GFP-tagged GTPase-deficient form of Rab5b (Rab5bQ79L) in NRK cells results in the sequential formation of three morphologically and functionally distinct...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.09.089

    authors： Hirota Y,Kuronita T,Fujita H,Tanaka Y

    更新日期：2007-12-07 00:00:00

  • Knockdown of TIGAR by RNA interference induces apoptosis and autophagy in HepG2 hepatocellular carcinoma cells.

    abstract：:Apoptosis and autophagy are crucial mechanisms regulating cell death, and the relationship between apoptosis and autophagy in the liver has yet to be thoroughly explored. TIGAR (TP53-induced glycolysis and apoptosis regulator), which is a p53-inducible gene, functions in the suppression of ROS (reactive oxygen species...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.06.072

    authors： Ye L,Zhao X,Lu J,Qian G,Zheng JC,Ge S

    更新日期：2013-07-26 00:00:00

  • Introduction of a glycosylation site in the constant region decreases the aggregation of adalimumab Fab.

    abstract：:The production of therapeutic monoclonal antibodies is costly; therefore, antigen-binding fragments (Fabs) can be used instead. However, their tendency toward aggregation can reduce the half-life in the plasma and the therapeutic effectiveness. To examine the effect of glycosylation on the properties of the Fab of a t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.06.071

    authors： Nakamura H,Oda-Ueda N,Ueda T,Ohkuri T

    更新日期：2018-09-05 00:00:00

  • The sterol-binding antibiotic nystatin inhibits entry of non-opsonized Leishmania donovani into macrophages.

    abstract：:Leishmania donovani is an obligate intracellular parasite that infects macrophages of the vertebrate host resulting in visceral leishmaniasis in humans, a major public health problem worldwide. The molecular mechanisms involved in internalization of Leishmania are still poorly characterized. We report here that choles...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.11.062

    authors： Tewary P,Veena K,Pucadyil TJ,Chattopadhyay A,Madhubala R

    更新日期：2006-01-13 00:00:00

  • Transcription factor levels in medullary thyroid carcinoma cells differentiated by Harvey ras oncogene: c-jun is increased.

    abstract：:In the TT cell line of human medullary thyroid carcinoma, the viral Harvey ras (v-rasH) oncogene induces differentiation, marked by morphological changes, diminution of growth, and increased expression of the calcitonin gene. Here, we show that the transcriptional factor c-jun is increased during v-rasH induced differ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)91251-m

    authors： Nelkin BD,Borges M,Mabry M,Baylin SB

    更新日期：1990-07-16 00:00:00

  • Metformin inhibits inflammatory response via AMPK-PTEN pathway in vascular smooth muscle cells.

    abstract：:Atherosclerosis is a chronic inflammation of the coronary arteries. Vascular smooth muscle cells (VSMCs) stimulated by cytokines and chemokines accelerate the inflammatory response and migrate to the injured endothelium during the progression of atherosclerosis. Activation of AMP activated protein kinase (AMPK), a key...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.07.165

    authors： Kim SA,Choi HC

    更新日期：2012-09-07 00:00:00

  • Long non-coding RNA PVT1 promotes glycolysis and tumor progression by regulating miR-497/HK2 axis in osteosarcoma.

    abstract：:Cancer cells usually utilize glucose as a carbon source for aerobic glycolysis, a phenomenon known as the Warburg effect. Increasing studies have shown that PVT1 (a long non-coding RNA, lncRNA) functions as critical regulator of multiple cancers. However, it remains totally unknown whether and how PVT1 regulates gluco...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.06.024

    authors： Song J,Wu X,Liu F,Li M,Sun Y,Wang Y,Wang C,Zhu K,Jia X,Wang B,Ma X

    更新日期：2017-08-19 00:00:00

  • Circular RNA circ-CBFB promotes proliferation and inhibits apoptosis in chronic lymphocytic leukemia through regulating miR-607/FZD3/Wnt/β-catenin pathway.

    abstract：:Circular RNA (circRNA) belongs to the non-coding RNA family and is involved in various human cancers, such as lung cancer and colorectal cancer. Nevertheless, whether circRNA expression is related to chronic lymphocytic leukemia (CLL) progression remains largely unclear. In our study, we investigated the role of circ-...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.06.045

    authors： Xia L,Wu L,Bao J,Li Q,Chen X,Xia H,Xia R

    更新日期：2018-09-03 00:00:00

  • A new member of the sorting nexin family interacts with the C-terminus of P-selectin.

    abstract：:P-selectin is a cell adhesion molecule found in platelets and endothelial cells mediating binding of leukocytes. It is stored in secretory granules and expressed at the plasma membrane after cell activation. After rapid internalisation P-selectin recycles or is degraded. The 35 amino acid cytoplasmic domain of P-selec...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4467

    authors： Florian V,Schlüter T,Bohnensack R

    更新日期：2001-03-09 00:00:00

  • Muscle death participates in myofibrillar abnormalities in FHL1 knockout mice.

    abstract：BACKGROUND:Mutations in the four and-a-half LIM domain protein 1 (FHL1) gene or FHL1 protein deletion have been identified as the cause of rare hereditary myopathies or cardiomyopathies. In our previous study, autophagy activation was associated with myofibrillar abnormalities in FHL1 knockout (KO) mice. P2RX7 induces ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.12.026

    authors： Ding J,Cong Y,Li F,Liu B,Wu D,Miao J,Wang L

    更新日期：2020-02-26 00:00:00

  • Target disruption of ribosomal protein pNO40 accelerates aging and impairs osteogenic differentiation of mesenchymal stem cells.

    abstract：:pNO40/PS1D, a novel nucleolar protein, has been characterized as a core protein of eukaryotic 60S ribosome and at least two splicing forms of pNO40 mRNAs with alternative starting sites have been identified. Through production of knockout (ko) mice with either exon 2 (△E2), exon 4 (△E4) or △E2+E4 targeted disruption w...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.12.003

    authors： Lin YM,Wu CC,Chang YC,Wu CH,Ho HL,Hu JW,Chang RC,Wang CT,Ouyang P

    更新日期：2016-01-22 00:00:00

  • Mermaid, a family of short interspersed repetitive elements, is useful for zebrafish genome mapping.

    abstract：:A family of short interspersed repetitive elements (SINEs), designated mermaid, is present in the genomes of fish, amphibian and primates, but absent in the mouse genome. We have demonstrated that the sequences of the mermaid family are highly polymorphic in the zebrafish genome as in the human genome. We have also sh...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0386

    authors： Shimoda N,Chevrette M,Ekker M,Kikuchi Y,Hotta Y,Okamoto H

    更新日期：1996-03-07 00:00:00

  • CCAAT/enhancer-binding protein CEBP-2 controls fat consumption and fatty acid desaturation in Caenorhabditis elegans.

    abstract：:Mammalian CCAAT/enhancer-binding proteins (C/EBPs) are generally known as regulators in adipocyte differentiation. However, more understanding of the role of C/EBPs in lipid and glucose metabolism remains to be discovered. In this study, we verified the effect of CEBP-2, the homolog of CEBPs, on fat storage in Caenorh...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.10.106

    authors： Xu XY,Hu JP,Wu MM,Wang LS,Fang NY

    更新日期：2015-12-04 00:00:00

  • A recombinant adenoviral vector encoding functional vasoactive intestinal peptide.

    abstract：:Vasoactive intestinal peptide (VIP) is a small neuropeptide, which exerts pleiotropic functions. Based on its immunomodulatory, secretory, and possibly trophic effects, VIP is a valuable candidate molecule for the management of autoimmune disease. The purpose of this study was to develop a recombinant viral vector cap...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.04.171

    authors： Lodde BM,Delporte C,Goldsmith CM,Tak PP,Baum BJ

    更新日期：2004-06-18 00:00:00

  • Direct measurement of nitric oxide production in platelets: relationship with cytosolic Ca2+ concentration.

    abstract：:NO production in platelets has been followed by electrochemical detection. It was undetectable in unstimulated platelets and in thrombin or ADP-stimulated platelets, but dose-dependently stimulated by collagen. A production of 5 10(-19) mol/platelet was reached with 9 micrograms collagen. In collagen-stimulated platel...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2540

    authors： Lantoine F,Brunet A,Bedioui F,Devynck J,Devynck MA

    更新日期：1995-10-24 00:00:00

  • Expression of the ED B fibronectin isoform in adult human articular cartilage.

    abstract：:The most recently described region of alternate splicing of fibronectin mRNA results in expression of an isoform which includes the type III repeat termed ED B (EIII B). To date this isoform has been detected in transformed cells in culture, in the synovial membrane and ovary but in no other adult tissue, and in embry...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(89)80034-8

    authors： Burton-Wurster N,Lust G,Wert R

    更新日期：1989-12-15 00:00:00

  • Antiproliferative effect of 1,25-dihydroxyvitamin D3 and its analogs on human colon adenocarcinoma cells (CaCo-2): influence of extracellular calcium.

    abstract：:Depending on culture in either "low Ca++" (0.25 mM) or "normal Ca++" (1.8 mM) medium, human colon adenocarcinoma-derived CaCo-2 cells exhibit differential sensitivity to the antiproliferative action of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and of two side-chain modified analogs, 1,25S,26-trihydroxy-delta 22-vitamin D...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)91333-8

    authors： Cross HS,Huber C,Peterlik M

    更新日期：1991-08-30 00:00:00

  • Regional determinants of arterial endothelial phenotype dominate the impact of gender or short-term exposure to a high-fat diet.

    abstract：:Regional arterial hemodynamics correlates with distinct endothelial phenotypes that may be modified by risk factors to influence focal and regional susceptibility to atherosclerosis. We compared endothelial transcript profiles from hemodynamically distinct arterial regions in 15 mature pigs: males and females fed a no...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.04.103

    authors： Passerini AG,Shi C,Francesco NM,Chuan P,Manduchi E,Grant GR,Stoeckert CJ Jr,Karanian JW,Wray-Cahen D,Pritchard WF,Davies PF

    更新日期：2005-06-24 00:00:00

  • Salivary phospholipid secretion in response to beta-adrenergic stimulation is mediated by Src kinase-dependent epidermal growth factor receptor transactivation.

    abstract：:Communication between receptor tyrosine kinase and G protein-coupled receptor (GPCR)-mediated signaling is recognized as a common integrator linking diverse aspects of intracellular signaling systems. Here, we report that G protein-coupled beta-adrenergic receptor activation leading to stimulation of salivary phosphol...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.04.016

    authors： Slomiany BL,Slomiany A

    更新日期：2004-05-21 00:00:00