Microbial polysaccharide, HS-142-1, competitively and selectively inhibits ANP binding to its guanylyl cyclase-containing receptor.

Abstract:

:During the search for ANP receptor ligands of microbial origin, we isolated a novel polysaccharide, HS-142-1, from culture broth of Aureobasidium sp. HS-142-1 inhibited [125I]-rANP binding to ANP receptor in rabbit kidney cortex membranes with an IC50 of 0.3 mu g/ml, but gave no effects on specific binding of [125I]-Endothelin nor [125I]-Angiotensin II to their respective receptors in bovine lung membranes. HS-142-1 competitively and selectively inhibited ANP binding to its guanylyl cyclase-containing receptor purified from solubilized bovine adrenocortical membranes and blocked cGMP production elicited by ANP. HS-142-1 is the first non-peptide antagonist selective for ANP functional receptor and will be a powerful tool to elucidate the physiological functions of ANP.

authors

Morishita Y,Sano T,Ando K,Saitoh Y,Kase H,Yamada K,Matsuda Y

doi

10.1016/0006-291x(91)90374-g

subject

Has Abstract

pub_date

1991-05-15 00:00:00

pages

949-57

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(91)90374-G

journal_volume

176

pub_type

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