Abstract:
:We investigated the effect of chronic alcohol ingestion on buccal mucosal ulcer healing by analyzing the interplay between mucosal expression of tumor necrosis factor-alpha (TNF-alpha), endothelin-1 (ET-1), and interleukin-4 (IL-4). Chronic ulceration was induced in rats maintained for 5 weeks on alcohol-containing or control liquid diet. In both groups, the ulcer onset was characterized by a massive increase (6.5-8.9-fold) in TNF-alpha and ET-1 (1.6-4.0-fold), and a decrease (1.4-1.5-fold) in IL-4. However, the group on the alcohol diet exhibited a 38.3% higher mucosal expression of TNF-alpha, a 26. 2% higher ET-1 level, and a 6.5% lower content of IL-4. While in both groups the ulcer healing was accompanied by an increase in buccal mucosal expression of IL-4, and a decline in ET-1 and TNF-alpha, the changes were significantly slower in the alcohol diet group and manifested by a 4 day delay in ulcer healing. The results suggest that chronic alcohol ingestion exerts detrimental effects on the buccal mucosal IL-4 expression, causing dysregulation of ET-1 production, induction of TNF-alpha, and triggering apoptotic events that delay the mucosal repair.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Slomiany BL,Piotrowski J,Slomiany Adoi
10.1006/bbrc.1999.0483subject
Has Abstractpub_date
1999-04-13 00:00:00pages
373-7issue
2eissn
0006-291Xissn
1090-2104pii
S0006-291X(99)90483-7journal_volume
257pub_type
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