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Classifier ensembles for protein structural class prediction with varying homology.

Abstract：

:Structural class characterizes the overall folding type of a protein or its domain. A number of computational methods have been proposed to predict structural class based on primary sequences; however, the accuracy of these methods is strongly affected by sequence homology. This paper proposes, an ensemble classification method and a compact feature-based sequence representation. This method improves prediction accuracy for the four main structural classes compared to competing methods, and provides highly accurate predictions for sequences of widely varying homologies. The experimental evaluation of the proposed method shows superior results across sequences that are characterized by entire homology spectrum, ranging from 25% to 90% homology. The error rates were reduced by over 20% when compared with using individual prediction methods and most commonly used composition vector representation of protein sequences. Comparisons with competing methods on three large benchmark datasets consistently show the superiority of the proposed method.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kedarisetti KD,Kurgan L,Dick S

doi

10.1016/j.bbrc.2006.07.141

subject

Has Abstract

pub_date

2006-09-29 00:00:00

pages

981-8

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)01705-0

journal_volume

348

pub_type

杂志文章

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