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A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line.

Abstract：

:Neurofibromatosis type 1 is a common genetic disease that causes nervous system tumors, and cognitive deficits. It is due to mutations within the NF1 gene, which encodes the Nf1 protein. Nf1 has been shown to be involved in the regulation of Ras, cAMP and actin cytoskeleton dynamics. In this study, using immunofluorescence experiments, we have shown a partial nuclear localization of Nf1 in the astrocytoma cell line: CCF and we have demonstrated that Nf1 partially colocalizes with PML (promyelocytic leukemia) nuclear bodies. A direct interaction between Nf1 and the multiprotein complex has further been demonstrated using "in situ" proximity ligation assay (PLA).

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Godin F,Villette S,Vallée B,Doudeau M,Morisset-Lopez S,Ardourel M,Hevor T,Pichon C,Bénédetti H

doi

10.1016/j.bbrc.2012.01.079

subject

Has Abstract

pub_date

2012-02-24 00:00:00

pages

689-94

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(12)00113-1

journal_volume

418

pub_type

杂志文章

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