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Lis1 dysfunction leads to traction force reduction and cytoskeletal disorganization during cell migration.

Abstract：

:Cell migration is a critical process during development, tissue repair, and cancer metastasis. It requires complex processes of cell adhesion, cytoskeletal dynamics, and force generation. Lis1 plays an important role in the migration of neurons, fibroblasts and other cell types, and is essential for normal development of the cerebral cortex. Mutations in human LIS1 gene cause classical lissencephaly (smooth brain), resulting from defects in neuronal migration. However, how Lis1 may affect force generation in migrating cells is still not fully understood. Using traction force microscopy (TFM) with live cell imaging to measure cellular traction force in migrating NIH3T3 cells, we showed that Lis1 knockdown (KD) by RNA interference (RNAi) caused reductions in cell migration and traction force against the extracellular matrix (ECM). Immunostaining of cytoskeletal components in Lis1 KD cells showed disorganization of microtubules and actin filaments. Interestingly, focal adhesions at the cell periphery were significantly reduced. These results suggest that Lis1 is important for cellular traction force generation through the regulation of cytoskeleton organization and focal adhesion formation in migrating cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Jheng GW,Hur SS,Chang CM,Wu CC,Cheng JS,Lee HH,Chung BC,Wang YK,Lin KH,Del Álamo JC,Chien S,Tsai JW

doi

10.1016/j.bbrc.2018.02.151

subject

Has Abstract

pub_date

2018-03-11 00:00:00

pages

869-875

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(18)30388-7

journal_volume

497

pub_type

杂志文章

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