Lupus autoantigen Ku protein binds HIV-1 TAR RNA in vitro.

abstract：:Eicosapentaenoic acid (EPA), an n-3 polyunsaturated fatty acid (PUFA), has been shown to decrease the risk of atherosclerosis by attenuating endothelial activation. In this study, we used mass spectrometry-based label-free quantitative proteomics to study the protective mechanisms of EPA and to identify key proteins t...

journal_title：Biochemical and biophysical research communications

authors： Zhang L,Xiao K,Zhao X,Sun X,Zhang J,Wang X,Zhu Y,Zhang X

更新日期：2017-05-27 00:00:00

abstract：:The IGF-1 receptor (IGF-1R) and MT1-MMP are synthesized as larger precursor proproteins, which require endoproteolytic activation by the proprotein convertases (PCs) furin/PC5 to gain full biological activity. The aim of this study was to investigate the contribution of PCs to IGF-1R and/or MT1-MMP activation in vascu...

journal_title：Biochemical and biophysical research communications

authors： Stawowy P,Kallisch H,Kilimnik A,Margeta C,Seidah NG,Chrétien M,Fleck E,Graf K

更新日期：2004-08-27 00:00:00

abstract：:In a gene chip analysis of common pituitary tumor types, one of the genes with the most impressive tissue-specific expression regulation was delta-like 1 (DLK1), which was strongly expressed in GH-secreting (GH-S) pituitary tumors. In addition to pituitary adenomas, various endocrine tumors were subjected to real-time...

journal_title：Biochemical and biophysical research communications

authors： Altenberger T,Bilban M,Auer M,Knosp E,Wolfsberger S,Gartner W,Mineva I,Zielinski C,Wagner L,Luger A

更新日期：2006-02-17 00:00:00

abstract：:3'-Azido-2',3'-dideoxyguanosine (AzddGuo) is a potent and selective inhibitor of human immunodeficiency virus (HIV) in vitro. AzddGuo completely inhibits HIV-induced cytopathogenicity and viral antigen expression in MT-4 cells at a concentration of 5.0 microM. Its 50% effective dose for inhibiting HIV-induced cytopath...

journal_title：Biochemical and biophysical research communications

authors： Baba M,Pauwels R,Balzarini J,Herdewijn P,De Clercq E

更新日期：1987-06-30 00:00:00

abstract：:MicroRNAs (miRNAs) are non-protein-coding RNAs that function as post-transcriptional gene regulators. Recent evidence has shown that miRNA plays a pivotal role in the development of many cancers including glioma, a lethal brain cancer. We have recently compared the miRNA expression profiles between normal brain and gl...

journal_title：Biochemical and biophysical research communications

authors： Xia H,Qi Y,Ng SS,Chen X,Chen S,Fang M,Li D,Zhao Y,Ge R,Li G,Chen Y,He ML,Kung HF,Lai L,Lin MC

更新日期：2009-03-06 00:00:00

abstract：:Acute lung injury (ALI) is a severe clinical condition with high morbidity and mortality. Apoptosis is a key pathologic feature of ALI, and Bcl-2 plays an important role during the pathogenesis of ALI via the regulation of apoptosis. However, the regulation of Bcl-2 during ALI, particularly through microRNAs, remains ...

journal_title：Biochemical and biophysical research communications

authors： Zhao J,Li X,Zou M,He J,Han Y,Wu D,Yang H,Wu J

更新日期：2014-10-03 00:00:00

abstract：:We have cloned and sequenced a full-length cDNA (1083 bp) encoding the human liver cystathionine-gamma-lyase enzyme (cystathionase). The human cystathionase sequence presented a substantial deletion of 132 bases (44 amino acids) compared to that reported for rat cystathionase, and of 135 bases (45 amino acids) compare...

journal_title：Biochemical and biophysical research communications

authors： Lu Y,O'Dowd BF,Orrego H,Israel Y

更新日期：1992-12-15 00:00:00

abstract：:The apical membrane of distal nephron epithelium (A6) had a Ca(2+)-activated outwardly rectifying Cl- channel with single-channel conductances of 3 pS for outward current and 0.8 pS for inward current. The single-channel conductance for inward current was dependent on cytosolic Ca2+ concentration. Insulin increased th...

journal_title：Biochemical and biophysical research communications

authors： Shintani Y,Marunaka Y

更新日期：1996-01-05 00:00:00

abstract：:Expression of brain-derived neurotrophic factor (BDNF) mRNA is increased in the dorsal root ganglion (DRG) in response to peripheral inflammation. Nerve growth factor (NGF) from inflammatory tissue is thought to induce expression of BDNF. Recently, it was reported that the BDNF gene has eight non-coding exons that are...

journal_title：Biochemical and biophysical research communications

authors： Matsuoka Y,Yokoyama M,Kobayashi H,Omori M,Itano Y,Morita K,Mori H,Nakanishi T

更新日期：2007-10-26 00:00:00

abstract：:The orderly progression of cell cycle depends on timely destruction of key regulators through ubiquitin-mediated proteolysis. The anaphase-promoting complex (APC) is a major component of this degradation machinery and its activation is regulated by CDC20 and CDH1. We demonstrate here that CDH1 mRNA is ubiquitously exp...

journal_title：Biochemical and biophysical research communications

authors： Zhou Y,Ching YP,Ng RW,Jin DY

更新日期：2002-05-31 00:00:00

abstract：:Human lactate dehydrogenase-A mutant gene was isolated from the genomic DNA library of a patient deficient in LDH-A (Muscle) subunit. The nucleotide sequences of seven protein-coding exons were determined and a deletion of 20 base-pairs in exon 6 was found. This mutation results in a frame-shift translation and premat...

journal_title：Biochemical and biophysical research communications

authors： Maekawa M,Sudo K,Kanno T,Li SS

更新日期：1990-04-30 00:00:00

abstract：:Free radicals attack lipid molecules and initiate a chain of reactions that may trigger several diseases such as atherosclerosis and cancer. Several markers of oxidative stress have been proposed, including measurements of lipid peroxides and short-chain aldehydes levels and evaluation of conjugated diene formation. A...

journal_title：Biochemical and biophysical research communications

authors： Visioli F,Colombo C,Galli C

更新日期：1998-04-17 00:00:00

abstract：:A folded synthetic peptide analog of NDF (NDF5), which has the 52 amino acid EGF-like domain of NDF alpha 2, has been characterized. The folded peptide stimulates tyrosine phosphorylation of Her2, Her3 and Her4 in breast cancer cells and competes with low affinity with full-length NDF alpha 2 for binding to the cells,...

journal_title：Biochemical and biophysical research communications

authors： Kita Y,Mayer J,Zamborelli T,Hara S,Rohde M,Watson E,Koski R,Ratzkin B,Nicolson M

更新日期：1995-05-16 00:00:00

abstract：:Two alternatively spliced Caenorhabditis elegans G protein-coupled receptors, T19F4.1a and T19F4.1b, were cloned and functionally characterized. The T19F4.1b receptor protein is 30 amino acids longer than T19F4.1a, and the difference in amino acid constitution is exclusively conferred to the intracellular C-terminal r...

journal_title：Biochemical and biophysical research communications

authors： Mertens I,Meeusen T,Janssen T,Nachman R,Schoofs L

更新日期：2005-05-13 00:00:00

abstract：:Transmissible gastroenteritis virus (TGEV), an enteropathogenic coronavirus, causes severe lethal watery diarrhea and dehydration in piglets. Previous studies indicate that TGEV infection induces cell apoptosis in host cells. In this study, we investigated the roles and regulation of reactive oxygen species (ROS) in T...

journal_title：Biochemical and biophysical research communications

authors： Ding L,Zhao X,Huang Y,Du Q,Dong F,Zhang H,Song X,Zhang W,Tong D

更新日期：2013-12-06 00:00:00

abstract：:Topical nuclear magnetic resonance spectroscopy (NMR) using a solenoid transmit/receiver coil has been used to monitor the kinetics of intragastric utilization of [1-13C] glucose in mice in vivo. Using a double-tuned solenoid coil, signal to noise response was excellent and the natural abundance in vivo 13C spectra ob...

journal_title：Biochemical and biophysical research communications

authors： Field J,Irving MG,Brooks WM,Doddrell DM

更新日期：1984-09-28 00:00:00

abstract：:Atomic force microscopy (AFM) allows to study the molecular structure of biological macromolecules with nm to A resolutions without crystallization. We show here the applicability of AFM in the quantitative analysis of the molecular mechanisms of DNA/protein interaction: (i) Protein-binding sites can be mapped over a ...

journal_title：Biochemical and biophysical research communications

authors： Nettikadan S,Tokumasu F,Takeyasu K

更新日期：1996-09-24 00:00:00

abstract：:The activation of vitamin D requires 25-hydroxylation in the liver and 1alpha-hydroxylation in the kidney. However, it remains unclear which enzyme is relevant to vitamin D 25-hydroxylation. Recently, human CYP2R1 has been reported to be a potential candidate for a hepatic vitamin D 25-hydroxylase. Thus, vitamin D met...

journal_title：Biochemical and biophysical research communications

authors： Shinkyo R,Sakaki T,Kamakura M,Ohta M,Inouye K

更新日期：2004-11-05 00:00:00

abstract：:Eight amino acid permease genes from the protozoan parasite Leishmania donovani (AAPLDs) were cloned, sequenced, and shown to be expressed in promastigotes. Seven of these belong to the amino acid transporter-1 and one to the amino acid polyamino-choline superfamilies. Using these sequences as well as known and charac...

journal_title：Biochemical and biophysical research communications

authors： Akerman M,Shaked-Mishan P,Mazareb S,Volpin H,Zilberstein D

更新日期：2004-12-03 00:00:00

abstract：:Exosomal microRNAs(miRNAs) transfer from tumor to stromal cells is reportedly associated with cancer progression and metastasis in various epithelial cancers. However, the role of exosomal miRNA in the metastasis of osteosarcoma(OS) -the most common bone malignancy-still largely remains unknown. In this study, we puri...

journal_title：Biochemical and biophysical research communications

authors： Gong L,Bao Q,Hu C,Wang J,Zhou Q,Wei L,Tong L,Zhang W,Shen Y

更新日期：2018-06-02 00:00:00

abstract：:ERK8 is the most recent addition for the MAPK family, and its mechanism of activation and function are not yet known, mainly due to the lack of any known physiological stimulator. In this report, we describe the preparation of reagents for the use of a novel method, the ligand interaction scan (LIScan), to study the f...

journal_title：Biochemical and biophysical research communications

authors： Erster O,Seger R,Liscovitch M

更新日期：2010-08-13 00:00:00

abstract：:RNA primer removal during DNA replication is dependent on ribonucleotide- and structure-specific RNase H and FEN-1 nuclease activities. A specific RNase H involved in this reaction has long been sought. RNase HII is the only open reading frame in Archaeoglobus fulgidus genome, while multiple RNases H exist in eukaryot...

journal_title：Biochemical and biophysical research communications

authors： Chai Q,Qiu J,Chapados BR,Shen B

更新日期：2001-09-07 00:00:00

abstract：:Low density lipoprotein (LDL) is readily oxidized under certain conditions, resulting in the formation of oxidized LDL (oxLDL). Despite numerous in vitro reports that reveal the pathogenic role of oxidative stress, anti-oxidative strategies have underperformed in the clinic. In this study, we examine the role of oxLDL...

journal_title：Biochemical and biophysical research communications

authors： Kim OS,Lee CS,Joe EH,Jou I

更新日期：2006-03-31 00:00:00

abstract：:Although "secretory" type II 14-kDa phospholipase A2 (sPLA2) activity has been described in neutrophils, direct evidence of enzyme secretion has been elusive. We have used immunogold electron microscopy with polyclonal and monoclonal antibodies to sPLA2 to demonstrate localization of the enzyme to granules of resting ...

journal_title：Biochemical and biophysical research communications

authors： Rosenthal MD,Gordon MN,Buescher ES,Slusser JH,Harris LK,Franson RC

更新日期：1995-03-17 00:00:00

abstract：:Hairpin antisense oligodeoxyribonucleotides containing 2'-methoxynucleosides were more active in the micromolar concentration range than linear and DNA hairpin phosphorothioate oligonucleotides with the same sequence. Furthermore, the abilities of hairpin antisense and random hairpin phosphorothioate oligonucleotides ...

journal_title：Biochemical and biophysical research communications

authors： Kuwasaki T,Hosono K,Takai K,Ushijima K,Nakashima H,Saito T,Yamamoto N,Takaku H

更新日期：1996-11-12 00:00:00

abstract：BACKGROUND:We investigated the role of the programmed cell death 4 (PDCD4) tumor suppressor gene in specimens of transitional cell carcinoma and of healthy individuals. METHODS:PDCD4 immunohistochemical expression was investigated in 294 cases in histologically proven transitional cell carcinoma in different tumorous ...

journal_title：Biochemical and biophysical research communications

authors： Fischer N,Göke F,Splittstösser V,Lankat-Buttgereit B,Müller SC,Ellinger J

更新日期：2012-01-06 00:00:00

abstract：:Our goal was to characterize the glucose transporter in synaptosomes and to compare it to the different forms of transporter already identified. Cross-reactivity with antibodies to the human erythrocyte transporter, Km of glucose uptake, reversibility of NEM inhibition of transport, and insulin sensitivity were all ex...

journal_title：Biochemical and biophysical research communications

authors： Bhattacharyya MV,Brodsky JL

更新日期：1988-09-15 00:00:00

abstract：:The mouse nuclear receptor ERRgamma (estrogen receptor-related receptor gamma) is highly expressed in heart, skeletal muscle, kidney, and brain, as well as in the developing nervous system. We found that the expression of the coactivators PGC-1 (PGC-1alpha) and PERC (PGC-1beta) in mammalian cells augmented potently th...

journal_title：Biochemical and biophysical research communications

authors： Hentschke M,Süsens U,Borgmeyer U

更新日期：2002-12-20 00:00:00

abstract：:Multi electrode arrays (MEAs) are increasingly used to detect external field potentials in electrically active cells. Recently, in combination with cardiomyocytes derived from human (induced) pluripotent stem cells they have started to become a preferred tool to examine newly developed drugs for potential cardiac toxi...

journal_title：Biochemical and biophysical research communications

authors： Tertoolen LGJ,Braam SR,van Meer BJ,Passier R,Mummery CL

更新日期：2018-03-18 00:00:00

abstract：:Information on the immune response against H5N1 within the lung is lacking. Here we describe the sustained antiviral immune responses, as indicated by the expression of MxA protein and IFN-alpha mRNA, in autopsy lung tissue from an H5N1-infected patient. H5N1 infection of primary bronchial/tracheal epithelial cells an...

journal_title：Biochemical and biophysical research communications

authors： Thitithanyanont A,Engering A,Uiprasertkul M,Ekchariyawat P,Wiboon-Ut S,Kraivong R,Limsalakpetch A,Kum-Arb U,Yongvanitchit K,Sa-Ard-Iam N,Rukyen P,Mahanonda R,Kawkitinarong K,Auewarakul P,Utaisincharoen P,Sirisinha S,Mason

更新日期：2010-08-06 00:00:00