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PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma.

Abstract：

:The mouse nuclear receptor ERRgamma (estrogen receptor-related receptor gamma) is highly expressed in heart, skeletal muscle, kidney, and brain, as well as in the developing nervous system. We found that the expression of the coactivators PGC-1 (PGC-1alpha) and PERC (PGC-1beta) in mammalian cells augmented potently the transcriptional activation by ERRgamma. The constitutive activation function 2 (AF-2) of the orphan receptor was important for the synergistic enhancement. Functional receptor truncation analysis revealed an additional amino-terminal activation function, specific for the ERRgamma2 isoform and PGC-1. In vitro experiments showed a direct interaction of ERRgamma with both coactivators. Our findings suggest distinct regulatory functions for PGC-1 and PERC as tissue-specific coactivators for ERRgamma.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hentschke M,Süsens U,Borgmeyer U

doi

10.1016/s0006-291x(02)02753-5

subject

Has Abstract

pub_date

2002-12-20 00:00:00

pages

872-9

issue

5

eissn

0006-291X

issn

1090-2104

pii

S0006291X02027535

journal_volume

299

pub_type

杂志文章

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