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Vasoconstrictor effects of sarafotoxins in rabbit aorta: structure-function relationships.

Abstract：

:The sarafotoxins SRTX-a, b and c from the venom of the snake Atractaspis engaddensis are 21-amino acid peptides that affect the cardiovascular system. They are strong vasoconstrictors, the potency of which may be in correlation with their primary structure: SRTX-a, which differs from SRTX-b in a single amino acid residue (Asn instead of Tyr), shows about half of its maximal vasoconstriction, while SRTX-c, which differs in 3 additional residues is a very weak vasoconstrictor and, at high doses, shows vasodilatory effects. Sequential application of the three isotoxins result in a summated response.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wollberg Z,Bdolah A,Kochva E

doi

10.1016/0006-291x(89)92006-8

subject

Has Abstract

pub_date

1989-07-14 00:00:00

pages

371-6

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)92006-8

journal_volume

162

pub_type

杂志文章

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