Role of phosphatidylserine in the MI-MII equilibrium of rhodopsin.

abstract：:Experiments were undertaken to examine the effects of reduced (GSH) and oxidized (GSSG) glutathione on lipid peroxidation of rat liver microsomes. Dependence on microsomal alpha-tocopherol was shown for the GSH inhibition of lipid peroxidation. However, when GSH (5 mM) and GSSG (2.5 mM) were combined in the assay syst...

journal_title：Biochemical and biophysical research communications

authors： Scholz RW,Graham KS,Reddy CC

更新日期：1990-01-30 00:00:00

abstract：:We previously showed that the epidermal growth factor (EGF) receptor in human A431 epidermoid carcinoma cells undergoes a slow post-translational modification whereby it acquires (t1/2 = 30-40 min) EGF binding capacity (Slieker, L.J., et. al. (1986) J. Biol. Chem., 261, 15233-15241). This activation occurs in the endo...

journal_title：Biochemical and biophysical research communications

authors： Slieker LJ,Martensen TM,Lane MD

更新日期：1988-05-31 00:00:00

abstract：:Strategies that antagonize growth factor signaling are attractive candidates for the biological therapy of brain tumors. HGF/NK2 is a secreted truncated splicing variant and potential antagonist of scatter factor/hepatocyte growth factor (SF/HGF), a multifunctional cytokine involved in the malignant progression of sol...

journal_title：Biochemical and biophysical research communications

authors： Guerin C,Luddy C,Abounader R,Lal B,Laterra J

更新日期：2000-06-24 00:00:00

abstract：:A pair of functional moieties, the carboxyl of an aspartic acid (Asp, D) residue and an N-methyl nicotinamide (NMeN) formed on amide linkage to the epsilon-amino group of the lysine (Lys, K) residue, are coupled to perform energy conversion by means of controlling the transition temperature, Tt, of a common hydrophobi...

journal_title：Biochemical and biophysical research communications

authors： Urry DW,Hayes LC,Gowda DC,Peng SQ,Jing N

更新日期：1995-05-25 00:00:00

abstract：:Complementation studies, using fused cell lines from patients with peroxisomal disorders, have shown correction of defective plasmalogen synthesis and phytanic acid oxidation as well as an increase in the number of peroxisomes. At least six complementation groups have been reported. We demonstrate here that complement...

journal_title：Biochemical and biophysical research communications

authors： McGuinness MC,Moser AB,Moser HW,Watkins PA

更新日期：1990-10-15 00:00:00

abstract：:The sequence for the 3' portion of amoB, a gene encoding a 43-kDa polypeptide component ammonia monooxygenase of Nitrosomonas europaea, is presented. The derived polypeptide has no homology with other known proteins. AmoA and amoB are the only open reading frames in the putative amo operon. ...

journal_title：Biochemical and biophysical research communications

authors： Bergmann DJ,Hooper AB

更新日期：1994-10-28 00:00:00

abstract：:Previous experiments have demonstrated that the intermediary metabolite 6-hydroxymethylbenzo[a] pyrene (HMBP) can be activated to the electrophilic mutagen, 6-sulfooxymethylbenzo[a]pyrene (SMBP), by rat and mouse liver PAPS-dependent sulfotransferase activity or by chemical synthesis. This aralkylating metabolite and ...

journal_title：Biochemical and biophysical research communications

authors： Flesher JW,Horn J,Lehner AF

更新日期：1997-05-29 00:00:00

abstract：:We have recently reported that synthetic peptide amides corresponding to regions of human FSH beta-subunit, hFSH-beta-(33-53) and hFSH-beta-(81-95), bind to receptor and stimulate estradiol biosynthesis by cultured rat Sertoli cells. Because of experimental difficulties caused by the presence of free sulfhydryl groups...

journal_title：Biochemical and biophysical research communications

authors： Grasso P,Crabb JW,Reichert LE Jr

更新日期：1993-01-15 00:00:00

abstract：:To explore the estrogen-regulated genes genome-widely in breast cancer, cap analysis of gene expression (CAGE) sequencing was performed in MCF-7 cells under estrogen treatment. Estrogen-regulated expressional changes were found in 1537 CAGE tag clusters (TCs) (⩾1.5 or ⩽0.66-folds). Among them, 15 TCs were situated in ...

journal_title：Biochemical and biophysical research communications

authors： Yamaga R,Ikeda K,Boele J,Horie-Inoue K,Takayama K,Urano T,Kaida K,Carninci P,Kawai J,Hayashizaki Y,Ouchi Y,de Hoon M,Inoue S

更新日期：2014-05-09 00:00:00

abstract：:The mRNA for the novel aldehyde dehydrogenase 5 (ALDH5) gene was detected in HuH7 hepatoma cells. The cells also expressed cytosolic aldehyde dehydrogenase (ALDH1) mRNA, but no mitochondrial aldehyde dehydrogenase (ALDH2) mRNA. Extracts of the hepatoma cells contained an enzymatic activity with an isoelectric point si...

journal_title：Biochemical and biophysical research communications

authors： Stewart MJ,Malek K,Xiao Q,Dipple KM,Crabb DW

更新日期：1995-06-06 00:00:00

abstract：:The ability of two 15-ketosubstituted sterols, 5alpha-cholest-8(14)-en-3beta-ol-15-one and 3beta-(2-hydroxyethoxy)-5alpha-cholest-8(14)-en-15-one, to alter the mRNA levels of 3-hydroxy-3-methylglutaryl-CoA reductase, low density lipoprotein receptor, and oxysterol binding protein was studied and compared with the effe...

journal_title：Biochemical and biophysical research communications

authors： Kisseleva AF,Goryunova LE,Planells R,Lafont H,Alquier C

更新日期：1999-06-16 00:00:00

abstract：:Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictor peptide with potent pressor activity. We studied the effect of ET-1 on release of arginine-vasopressin (AVP) from perifused rat hypothalamus. ET-1 (10(-10) to 10(-8) M) significantly stimulated AVP release. The ET-1-induced AVP release was completely blocke...

journal_title：Biochemical and biophysical research communications

authors： Shichiri M,Hirata Y,Kanno K,Ohta K,Emori T,Marumo F

更新日期：1989-09-29 00:00:00

abstract：:Overexpression in Escherichia coli of the fdx4 gene from Aquifex aeolicus has allowed isolation and characterization of the first hyperthermophilic [2Fe-2S](Scys)(4) protein, a homodimer of M = 2 x 12.4 kDa with one [2Fe-2S] cluster per subunit. This protein is undamaged by heating to 100 degrees C for at least three ...

journal_title：Biochemical and biophysical research communications

authors： Chatelet C,Gaillard J,Pétillot Y,Louwagie M,Meyer J

更新日期：1999-08-11 00:00:00

abstract：:AIDS patients (2 groups) had a blood deficiency (p less than 0.001) of coenzyme Q10 vs. 2 control groups. AIDS patients had a greater deficiency (p less than 0.01) than ARC patients. ARC patients had a deficiency (p less than 0.05) vs. control. HIV-infected patients had a deficiency (p less than 0.05) vs. control. The...

journal_title：Biochemical and biophysical research communications

authors： Folkers K,Langsjoen P,Nara Y,Muratsu K,Komorowski J,Richardson PC,Smith TH

更新日期：1988-06-16 00:00:00

abstract：:The tailspike protein (TSP) of bacteriophage P22 is a homotrimeric multifunctional protein responsible for recognition and hydrolysis of Salmonella typhimurium host receptors. Once properly folded, TSP shows an unusual stability to temperature and detergent denaturation, prompting the analysis of TSP as a framework fo...

journal_title：Biochemical and biophysical research communications

authors： Carbonell X,Villaverde A

更新日期：1998-03-17 00:00:00

abstract：:Because brain inositides are enriched in the 1-stearoyl-2-arachidonoyl species, they form a likely source for the tetraenoic free fatty acids (FFA) and diacylglycerols (DG) that are accumulated during seizures. To study inositide turnover during bicuculline-induced seizures, rats were injected intraventricularly and b...

journal_title：Biochemical and biophysical research communications

authors： Van Rooijen LA,Vadnal R,Dobard P,Bazan NG

更新日期：1986-04-29 00:00:00

abstract：:Bone homeostasis is maintained by bone remodeling, which involves continuous bone resorption by osteoclasts and bone formation by osteoblasts. Dysregulation of bone turnover, caused by osteoclast overactivation, causes destructive bone diseases. However, the mechanisms underlying the maintenance of osteoclast differen...

journal_title：Biochemical and biophysical research communications

authors： Aoki S,Shimizu K,Ito K

更新日期：2020-07-05 00:00:00

abstract：:Estrogen-dependent diseases, especially breast cancers, are frequently treated with aromatase inhibitors. Another more recent strategy is the antisense technology. In this study, after predicting aromatase mRNA secondary structure, we describe the design, the efficiency, and the toxicity of two antisense phosphorothio...

journal_title：Biochemical and biophysical research communications

authors： Auvray P,Sourdaine P,Séralini GE

更新日期：1998-12-09 00:00:00

abstract：:Rats consume most of their daily food intake at night; serum leptin levels and adipose tissue leptin mRNA content are elevated at night in non-lactating rats fed ad libitum. Lactation induces massive hyperphagia with most food still consumed at night, but the nocturnal increase in leptin secretion was not observed in ...

journal_title：Biochemical and biophysical research communications

authors： Pickavance L,Tadayyon M,Williams G,Vernon RG

更新日期：1998-07-09 00:00:00

abstract：:The bromodomain and extraterminal (BET) domain family proteins are epigenetic modulators involved in the reading of acetylated lysine residues. The first BET protein inhibitor to be identified, (+)-JQ1, a thienotriazolo-1, 4-diazapine, binds selectively to the acetyl lysine-binding pocket of BET proteins. We evaluated...

journal_title：Biochemical and biophysical research communications

authors： Goupille O,Penglong T,Kadri Z,Granger-Locatelli M,Fucharoen S,Maouche-Chrétien L,Prost S,Leboulch P,Chrétien S

更新日期：2016-04-15 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been isolated from various tissues and used for elucidating the pathogenesis of numerous diseases. In our previous in vitro study, we showed the existence of MSCs in human spinal ligaments and hypothesized that these MSCs contributed to the pathogenesis of ossification of spinal liga...

journal_title：Biochemical and biophysical research communications

authors： Chin S,Furukawa K,Ono A,Asari T,Harada Y,Wada K,Tanaka T,Inaba W,Mizukami H,Motomura S,Yagihashi S,Ishibashi Y

更新日期：2013-07-12 00:00:00

abstract：:Membrane rafts are small and dynamic regions enriched in sphingolipids, cholesterol, ganglioside GM1 and protein markers like flotillins, forming the flatter domains or caveolins, which are characterized as stable flask-shape invaginations. We explored whether membrane rafts participate in the entry of Trypanosoma cru...

journal_title：Biochemical and biophysical research communications

authors： Barrias ES,Dutra JM,De Souza W,Carvalho TM

更新日期：2007-11-23 00:00:00

abstract：:Hsp90 interacts with proteins that mediate signaling pathways involved in the regulation of essential processes such as proliferation, cell cycle control, angiogenesis and apoptosis. Hsp90 inhibition is therefore an attractive strategy for blocking abnormal pathways that are crucial for cancer cell growth. In the pres...

journal_title：Biochemical and biophysical research communications

authors： Zuo K,Li D,Pulli B,Yu F,Cai H,Yuan X,Zhang X,Lv Z

更新日期：2012-05-04 00:00:00

abstract：:Lysine-specific demethylase 1 (LSD1) is upregulated in many cancers, especially neuroblastoma. We set out to explore whether geranylgeranoic acid (GGA) inhibits LSD1 activity by using recombinant human LSD1. GGA inhibited LSD1 activity with IC50 similar to that of the clinically used drug tranylcypromine. In human neu...

journal_title：Biochemical and biophysical research communications

authors： Sakane C,Okitsu T,Wada A,Sagami H,Shidoji Y

更新日期：2014-01-31 00:00:00

abstract：:Sequence analysis of a new lignin peroxidase (LIP) gene, GLG6, from P. chrysosporium showed that it encodes a mature LIP protein with a predicted Mr of 36,454. A 28 aa signal peptide precedes the mature protein. The coding region of GLG6 is interrupted by nine introns ranging in size from 50-57 bp. GLG6 encoded-LIP ha...

journal_title：Biochemical and biophysical research communications

authors： Naidu PS,Zhang YZ,Reddy CA

更新日期：1990-12-31 00:00:00

abstract：:In this report we demonstrate formation of a triplex structure by an antiparallel RNA oligonucleotide corresponding to the 21 bp polypurine-pyrimidine stretch from -141 to -162 of the rat alpha 1(I) procollagen promoter with a Kd of 0.1-0.2 microM. The formation of triplexes by the triplex forming oligoribonucleotide ...

journal_title：Biochemical and biophysical research communications

authors： Ririe SS,Guntaka RV

更新日期：1998-08-10 00:00:00

abstract：:A bank of pTV32 (Tn 917 lacZ) - generated Bacillus subtilis mutants were examined on milk agar for the ability to produce proteases at 48 degrees C. A single mutant, BUL786, was isolated, which could hydrolyze casein after overnight incubation at 48 degrees C. This mutant secreted protease 10 fold more at 48 degrees C...

journal_title：Biochemical and biophysical research communications

authors： Qoronfleh MW,Streips UN

更新日期：1986-07-31 00:00:00

abstract：:NAD+ is a co-enzyme in redox reactions and a substrate required for activity of various enzyme families, including sirtuins and poly(ADP-ribose) polymerases. Dietary supplementation of NAD+ precursors nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR) protects against metabolic disease, neurodegenerative ...

journal_title：Biochemical and biophysical research communications

authors： Fan R,Cui J,Ren F,Wang Q,Huang Y,Zhao B,Wei L,Qian X,Xiong X

更新日期：2018-06-02 00:00:00

abstract：:Gliomas are the leading cause of death among adults with primary brain malignancies. Treatment for malignant gliomas remains limited, and targeted therapies have been incompletely explored. Nuclear factor erythroid 2-related factor 2 (Nrf2), a key transcription regulator for antioxidant and detoxification enzymes, is ...

journal_title：Biochemical and biophysical research communications

authors： Jia Y,Wang H,Wang Q,Ding H,Wu H,Pan H

更新日期：2016-01-15 00:00:00

abstract：:In a recent publication [Biochem. Biophys. Res. Commun. 317 (2004) 957] it was proposed that the 'effective number of codons' (Nc) in a gene should be calculated by summing the individual amino acid Nc's using rounding whenever the codon homozygosities are lower than the reciprocal value of the number of members of th...

journal_title：Biochemical and biophysical research communications

authors： Fuglsang A

更新日期：2005-02-04 00:00:00