Effect of endothelin-1 on release of arginine-vasopressin from perifused rat hypothalamus.

Abstract:

:Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictor peptide with potent pressor activity. We studied the effect of ET-1 on release of arginine-vasopressin (AVP) from perifused rat hypothalamus. ET-1 (10(-10) to 10(-8) M) significantly stimulated AVP release. The ET-1-induced AVP release was completely blocked in the presence of nicardipine. Our results suggest a possible involvement of ET in the regulation of AVP release.

authors

Shichiri M,Hirata Y,Kanno K,Ohta K,Emori T,Marumo F

doi

10.1016/0006-291x(89)91124-8

subject

Has Abstract

pub_date

1989-09-29 00:00:00

pages

1332-7

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)91124-8

journal_volume

163

pub_type

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