Abstract:
:Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictor peptide with potent pressor activity. We studied the effect of ET-1 on release of arginine-vasopressin (AVP) from perifused rat hypothalamus. ET-1 (10(-10) to 10(-8) M) significantly stimulated AVP release. The ET-1-induced AVP release was completely blocked in the presence of nicardipine. Our results suggest a possible involvement of ET in the regulation of AVP release.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Shichiri M,Hirata Y,Kanno K,Ohta K,Emori T,Marumo Fdoi
10.1016/0006-291x(89)91124-8subject
Has Abstractpub_date
1989-09-29 00:00:00pages
1332-7issue
3eissn
0006-291Xissn
1090-2104pii
0006-291X(89)91124-8journal_volume
163pub_type
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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