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Calmodulin regulation of cholinergic muscarinic receptor: effects of calcium and phosphorylating states.

Abstract：

:Calmodulin (CaM) regulation of cholinergic muscarinic receptor was investigated using synaptic membrane isolated from rat brains and [3H]-QNB as a binding ligand. CaM exerts a biphasic effect on receptor binding showing both a Ca2+-dependent receptor loss and an increase depending on the state of membrane phosphorylation. Calcineurin, a CaM-dependent protein phosphatase, mimicked the stimulatory effect of CaM in a dose-dependent manner. CaM-antagonists, W-7 and TFP reversed the stimulatory effect by CaM. A mechanism of protein phosphorylation and dephosphorylation of the cholinergic muscarinic receptors regulated by CaM-Ca2+ was proposed.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ho AK,Wang JH

doi

10.1016/0006-291x(85)91263-x

subject

Has Abstract

pub_date

1985-12-31 00:00:00

pages

1193-200

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(85)91263-X

journal_volume

133

pub_type

杂志文章

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