Alterations in intermediate filament proteins in rat kidney proximal tubule epithelial cells.

abstract：:Membrane-type 1 matrix metalloproteinase (MT1-MMP) localized on the plasma membrane plays a central role in various normal biological responses including tissue remodeling, wound heeling, and angiogenesis and in cancer cell invasion and metastasis, by functioning as a collagenase and activating other matrix metallopro...

journal_title：Biochemical and biophysical research communications

authors： Miyata T,Ohnishi H,Suzuki J,Yoshikumi Y,Ohno H,Mashima H,Yasuda H,Ishijima T,Osawa H,Satoh K,Sunada K,Kita H,Yamamoto H,Sugano K

更新日期：2004-10-08 00:00:00

abstract：BACKGROUND:Recently, it has been reported that hypoxia highly enhances expression of peptidylarginine deiminase (PAD) 4 and production of citrullinated proteins in some tumor cells. However, little is known about malignant gliomas on this issue. Therefore, we here investigated whether expression of PADs was induced by ...

journal_title：Biochemical and biophysical research communications

authors： Sase T,Arito M,Onodera H,Omoteyama K,Kurokawa MS,Kagami Y,Ishigami A,Tanaka Y,Kato T

更新日期：2017-01-01 00:00:00

abstract：:Daudi lymphoma cells, of a line sensitive to growth inhibition by alpha interferon, showed dose-dependent plasma membrane depolarization within 10 min after exposure to natural or recombinant alpha interferons (10 to 1000 IU/ml). This biophysical change was detected flow cytometrically by measuring the intensity of fl...

journal_title：Biochemical and biophysical research communications

authors： Grimley PM,Aszalos A

更新日期：1987-07-15 00:00:00

abstract：:Platelet activating factor was isolated from the lesional scale of psoriatic patients using the method described by Bligh and Dyer (8). The extract was subjected to thin layer chromatography, and the region of the plate co-migrating with platelet activating factor removed. A portion of each sample was assayed for aggr...

journal_title：Biochemical and biophysical research communications

authors： Mallet AI,Cunningham FM

更新日期：1985-01-16 00:00:00

abstract：:Homologous-recombination (HR)-dependent repair defective cells are hypersensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. Combinations of defective HR pathway and PARP inhibitors have been an effective chemotherapeutic modality. We previously showed that knockdown of the WD40-repeat containing protein, Uaf1...

journal_title：Biochemical and biophysical research communications

authors： Choi YE,Park E

更新日期：2015-03-13 00:00:00

abstract：:Ribonuclease P (RNase P) is an endonuclease responsible for generating the 5(') end of matured tRNA molecules. A homology search of the hyperthermophilic archaeon Pyrococcus horikoshii OT3 genome database revealed that the four genes, PH1481, PH1601, PH1771, and PH1877, have a significant homology to those encoding RN...

journal_title：Biochemical and biophysical research communications

authors： Kouzuma Y,Mizoguchi M,Takagi H,Fukuhara H,Tsukamoto M,Numata T,Kimura M

更新日期：2003-07-04 00:00:00

abstract：:In growing neurite of neuronal cells, it is suggested that α/β-tubulin heterodimers assemble to form microtubule, and assembly of microtubule promotes neurite elongation. On the other hand, recent studies reveal importance of intracellular Cl(-) in regulation of various cellular functions such as cell cycle progressio...

journal_title：Biochemical and biophysical research communications

authors： Nakajima K,Niisato N,Marunaka Y

更新日期：2012-08-24 00:00:00

abstract：:Human neuropeptide Y (NPY) analog ANA-NPY or [L17, Q19, A20, A23, L28, L31]NPY (13-36)-amide binds weakly to postjunctional receptors to raise blood pressure but binds tightly to prejunctional receptors to inhibit neurotransmitter release. ANA-NPY forms a well-conserved anti-parallel helical structure overlapping E23-...

journal_title：Biochemical and biophysical research communications

authors： Barden JA

更新日期：1995-10-04 00:00:00

abstract：:DmTTF is a Drosophila melanogaster mitochondrial DNA-binding protein which binds specifically to two homologous non-coding sequences located at the 3' ends of blocks of genes encoded on opposite strands. In order to test whether this protein acts as transcription termination factor, we assayed the capacity of DmTTF to...

journal_title：Biochemical and biophysical research communications

authors： Roberti M,Fernandez-Silva P,Polosa PL,Fernandez-Vizarra E,Bruni F,Deceglie S,Montoya J,Gadaleta MN,Cantatore P

更新日期：2005-05-27 00:00:00

abstract：:The negative regulator of DNA-binding/cell-differentiation Id2 is a small protein containing a central helix-loop-helix (HLH) motif and a C-terminal nuclear export signal (NES). Whereas the former is essential for Id2 dimerization and nuclear localization, the latter is responsible for the transport of Id2 from the nu...

journal_title：Biochemical and biophysical research communications

authors： Colombo N,Schroeder J,Cabrele C

更新日期：2006-07-21 00:00:00

abstract：:The entire coding region of chlL, an essential chloroplast gene required for chlorophyll biosynthesis in the dark in Chlamydomonas reinhardtii, was precisely replaced by either the Klebsiella pneumoniae nifH (encoding the structural component of nitrogenase Fe protein) or the Escherichia coli uidA reporter gene encodi...

journal_title：Biochemical and biophysical research communications

authors： Cheng Q,Day A,Dowson-Day M,Shen GF,Dixon R

更新日期：2005-04-15 00:00:00

abstract：:Transient receptor potential (TRP) proteins are cation channels that comprise a superfamily of molecular sensors that enable animals to detect a wide variety of environmental stimuli. This versatility enables vertebrate and invertebrate TRP channels to function in a diversity of senses, ranging from vision to taste, s...

journal_title：Biochemical and biophysical research communications

authors： Liu C,Montell C

更新日期：2015-04-24 00:00:00

abstract：:Two novel subtilisin-like serine proteases (AS-E1 and -E2) that activate prothrombin have been identified in a culture of the fungus Acremonium sp. The enzymes were purified through repeated hydrophobic interaction chromatography. The N-terminal sequences of AS-E1 (34.4 kDa) and AS-E2 (32 kDa) showed high similarity t...

journal_title：Biochemical and biophysical research communications

authors： Liu C,Matsushita Y,Shimizu K,Makimura K,Hasumi K

更新日期：2007-06-22 00:00:00

abstract：:Endocannabinoids including anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are important lipid mediators for immunosuppressive effects and for appropriate homeostasis via their G-protein-coupled cannabinoid (CB) receptors in mammalian organs and tissues, and may be involved in wound healing in some organs. The phys...

journal_title：Biochemical and biophysical research communications

authors： Kozono S,Matsuyama T,Biwasa KK,Kawahara K,Nakajima Y,Yoshimoto T,Yonamine Y,Kadomatsu H,Tancharoen S,Hashiguchi T,Noguchi K,Maruyama I

更新日期：2010-04-16 00:00:00

abstract：:The product of the spontaneous dimerization and decarboxylation of aminoethylcysteine ketimine (simply named the dimer in this note) has been investigated for a possible biochemical activity. It has been found that the dimer inhibits the ADP-dependent oxidation of NAD(+)-linked substrates in rat liver mitochondria and...

journal_title：Biochemical and biophysical research communications

authors： Pecci L,Montefoschi G,Fontana M,Cavallini D

更新日期：1994-03-15 00:00:00

abstract：:Platelets are an important place for the storage of angiogenic factors, such as vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF). The present study aims to investigate the interaction between BDNF-TrkB pathway and platelet activation during tumor development. In an orthotopic hepa...

journal_title：Biochemical and biophysical research communications

authors： Yang ZF,Ho DW,Lau CK,Tam KH,Lam CT,Poon RT,Fan ST

更新日期：2006-08-04 00:00:00

abstract：:Mutants of mouse T-lymphoma S49 cells lacking thymidine kinase activity or deficient in nucleoside transport were selected by growth in the presence of 5'-fluorodeoxyuridine and their sensitivity to interferon tested. All five thymidine kinase and both transport deficient mutants were sensitive to the antiproliferativ...

journal_title：Biochemical and biophysical research communications

authors： Gewert DR,Cohen A,Williams BR

更新日期：1984-01-13 00:00:00

abstract：:Growing evidence indicates that endoplasmic reticulum (ER) stress and/or ER stress-mediated apoptosis may play a role in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease. The present study investigated the effects of non-cytotoxic concentrations of nitric oxide (NO) and nitrite, a metabolite ...

journal_title：Biochemical and biophysical research communications

authors： Jeong SO,Son Y,Lee JH,Choi SW,Kim SH,Cheong YK,Chung HT,Pae HO

更新日期：2017-11-04 00:00:00

abstract：:The protein kinase C inhibitor C-I reduced superoxide production by human neutrophils in response to phorbol myristate acetate by greater than 50%. In contrast to its effects in oxidative metabolism, 100 microM C-I caused minimal inhibition (5-18%) of lysozyme release in response to phorbol myristate acetate. Enzyme r...

journal_title：Biochemical and biophysical research communications

authors： Salzer W,Gerard C,McCall C

更新日期：1987-10-29 00:00:00

abstract：:Due to their spontaneous accumulation in inflamed or infected areas, blood phagocytes are potent drug vectors with specific targeting. Drug like molecule loading was obtained by use of cell electropermeabilization in which the impermeability of their plasma membrane is transiently impaired. Electrical conditions were ...

journal_title：Biochemical and biophysical research communications

authors： Sixou S,Teissié J

更新日期：1992-07-31 00:00:00

abstract：:Multidrug-resistant cells are characterized by the presence of P-glycoprotein on the plasma membrane, which binds and probably transports antitumor agents outside the cells. P-glycoprotein is also present in various normal tissues such as the adrenal gland. To investigate the physiological function of P-glycoprotein, ...

journal_title：Biochemical and biophysical research communications

authors： Naito M,Yusa K,Tsuruo T

更新日期：1989-02-15 00:00:00

abstract：:Transforming growth factor-β (TGF-β) signaling has been significantly implicated in the pathogenesis of aneurysm, prominently the initiation and progression of abdominal aortic aneurysm (AAA). Vascular smooth muscle cell (SMC) is the principal resident cell in aortic wall and is essential for its structure and functio...

journal_title：Biochemical and biophysical research communications

authors： Gao F,Chambon P,Offermanns S,Tellides G,Kong W,Zhang X,Li W

更新日期：2014-11-07 00:00:00

abstract：:Methylated lysyl and arginyl residues are present in the two major heat shock proteins, hsp70A and hsp70B, of chicken embryo fibroblasts. Here, we demonstrate that this methylation can be modulated by sodium arsenite, a chemical that increases the synthesis of hsp70. In particular, in hsp70A the amount of epsilon-N-tr...

journal_title：Biochemical and biophysical research communications

authors： Wang C,Lazarides E

更新日期：1984-03-15 00:00:00

abstract：:Enterococcus faecalis (E. faecalis) infection is considered an important etiological factor for the development of persistent apical periodontitis (PAP), but the exact mechanisms of autophagy between E. faecalis and immune cells remain unknown. In this study, we elucidated how E. faecalis lipoteichoic acid (LTA) is as...

journal_title：Biochemical and biophysical research communications

authors： Lin D,Gao Y,Zhao L,Chen Y,An S,Peng Z

更新日期：2018-04-15 00:00:00

abstract：:The heat shock response is known to inhibit NF-kappaB activation and NF-kappaB-dependent gene expression. Herein we determined if cells lacking heat shock factor-1 (HSF-1), the major transcription factor regulating heat shock protein gene expression, have an altered ability to modulate NF-kappaB activation. Embryonic ...

journal_title：Biochemical and biophysical research communications

authors： Malhotra V,Eaves-Pyles T,Odoms K,Quaid G,Shanley TP,Wong HR

更新日期：2002-03-01 00:00:00

abstract：:Rats were fed for 15 days a diet containing ammonium acetate (20% w/w) and then injected i. p. with ammonium acetate (7 mmol/Kg). Only 1 out of 18 control rats but 9 of 18 rats fed ammonium survived, indicating a protective effect of ammonium ingestion against an acute ammonia challenge. Blood ammonia returned to norm...

journal_title：Biochemical and biophysical research communications

authors： Miñana MD,Felipo V,Grisolía S

更新日期：1988-06-30 00:00:00

abstract：:Drosophila DLG (Discs Large Tumor Suppresser Protein) is a component of septate junctions, and disruption of its gene leads to over growth of imaginal discs. Homologs of Drosophila DLG recently isolated from mammalian tissue have been classified as members of the MAGUK (Membrane Associated GUanylate Kinase) superfamil...

journal_title：Biochemical and biophysical research communications

authors： Inagaki H,Maeda S,Lin KH,Shimizu N,Saito T

更新日期：1999-11-19 00:00:00

abstract：:Transcription factor NF-kappaB has both pro-apoptotic and anti-apoptotic properties depending on the cell type. Its role in the intestinal epithelial cell has not been well elucidated. Trefoil factor 3 (TFF3) is an anti-apoptotic peptide secreted by intestinal goblet cells. Here we show that TFF3 activated NF-kappaB p...

journal_title：Biochemical and biophysical research communications

authors： Chen YH,Lu Y,De Plaen IG,Wang LY,Tan XD

更新日期：2000-08-11 00:00:00

abstract：:Although mast cells are traditionally thought to function as effector cells in allergic responses, they have increasingly been recognized as important regulators of various immune responses. Mast cells mature locally; thus, tissue-specific influences are important for promoting mast cell accumulation and survival in t...

journal_title：Biochemical and biophysical research communications

authors： Cho KA,Park M,Kim YH,Woo SY

更新日期：2017-06-10 00:00:00

abstract：:Triple A syndrome is an autosomal recessive neurological disease, mimicking motor neuron disease, and is caused by mutant ALADIN, a nuclear-pore complex component. We recently discovered that the pathogenesis involved impaired nuclear import of DNA repair proteins, including DNA ligase I and the cerebellar ataxia caus...

journal_title：Biochemical and biophysical research communications

authors： Kiriyama T,Hirano M,Asai H,Ikeda M,Furiya Y,Ueno S

更新日期：2008-10-03 00:00:00