Unique inhibitory profile of platelet activating factor induced calcium mobilization, polyphosphoinositide turnover and granule enzyme secretion in rabbit neutrophils towards pertussis toxin and phorbol ester.

abstract：:The isolated oesophagus of Lymnaea stagnalis was used as a bioassay preparation to identify peptides that modulate the activity of the oesophagus. Several modulatory messengers were detected from the oesophageal extract. One of these, having an excitatory action, was further purified from both the oesophagus and the c...

journal_title：Biochemical and biophysical research communications

authors： Li KW,Holling T,de With ND,Geraerts WP

更新日期：1993-12-30 00:00:00

abstract：:A screening system comprised of a randomized hybrid-ribozyme library has previously been used to identify pro-death genes in Fas-mediated apoptosis, and short sequence information of candidate genes from this system was previously reported by Kawasaki and Taira [H. Kawasaki, K. Taira, A functional gene discovery in th...

journal_title：Biochemical and biophysical research communications

authors： Lee MR,Shin JN,Moon AR,Park SY,Hong G,Lee MJ,Yun CW,Seol DW,Piya S,Bae J,Oh JW,Kim TH

更新日期：2008-06-06 00:00:00

abstract：:Probiotics exhibit beneficial functions for host homeostasis maintenance. We herein investigated the mechanism by which Lactobacillus brevis-derived poly P exhibited a beneficial function. Immunostaining indicated that poly P was captured in the plasma membrane via integrin β1 in Caco2/bbe cells. The uptake of poly P ...

journal_title：Biochemical and biophysical research communications

authors： Tanaka K,Fujiya M,Konishi H,Ueno N,Kashima S,Sasajima J,Moriichi K,Ikuta K,Tanabe H,Kohgo Y

更新日期：2015-11-20 00:00:00

abstract：:Iron overload, as a risk factor for osteoporosis, can result in the up-regulation of Hepcidin, and Hepcidin knockout mice display defects in their bone microarchitecture. However, the molecular and genetic mechanisms underlying Hepcidin deficiency-derived bone loss remain unclear. Here, we show that hepcidin knockdown...

journal_title：Biochemical and biophysical research communications

authors： Jiang Y,Yan Y,Wang X,Zhu G,Xu YJ

更新日期：2016-07-15 00:00:00

abstract：:3'-Azido-2',3'-dideoxyguanosine (AzddGuo) is a potent and selective inhibitor of human immunodeficiency virus (HIV) in vitro. AzddGuo completely inhibits HIV-induced cytopathogenicity and viral antigen expression in MT-4 cells at a concentration of 5.0 microM. Its 50% effective dose for inhibiting HIV-induced cytopath...

journal_title：Biochemical and biophysical research communications

authors： Baba M,Pauwels R,Balzarini J,Herdewijn P,De Clercq E

更新日期：1987-06-30 00:00:00

abstract：:P53 is renowned as a cellular tumor suppressor poised to instigate remedial responses to various stress insults that threaten DNA integrity. P53 levels and activities are kept under tight regulation involving a complex network of activators and inhibitors, which determine the type and extent of p53 growth inhibitory s...

journal_title：Biochemical and biophysical research communications

authors： Levav-Cohen Y,Goldberg Z,Zuckerman V,Grossman T,Haupt S,Haupt Y

更新日期：2005-06-10 00:00:00

abstract：:Dexamethasone (DEX), a potent glucocorticoid, increased the expression of T-cell death associated gene 8 (TDAG8), a proton-sensing G protein-coupled receptor, which is associated with the enhancement of acidic pH-induced cAMP accumulation, in peritoneal macrophages. We explored the role of increased TDAG8 expression i...

journal_title：Biochemical and biophysical research communications

authors： He XD,Tobo M,Mogi C,Nakakura T,Komachi M,Murata N,Takano M,Tomura H,Sato K,Okajima F

更新日期：2011-12-02 00:00:00

abstract：:We investigated the role of Toll-like receptor 4 (TLR4), a major mediator of innate immune responses, on cognitive performance in a type 1 diabetes model (T1D). After administration of streptozotocin, both TLR4 knockout (TLR4 KO) and wild type (WT) diabetic mice displayed metabolic alterations similar to those observe...

journal_title：Biochemical and biophysical research communications

authors： Kawamoto EM,Cutler RG,Rothman SM,Mattson MP,Camandola S

更新日期：2014-01-10 00:00:00

abstract：:We examined age-associated changes of respiratory enzyme activities and protein synthesis in mitochondria isolated from mouse brain with high oxidative activities. Cytochrome c oxidase activity increased unexpectedly with aging, while the mitochondrial translational activities showed two phases of alterations: they in...

journal_title：Biochemical and biophysical research communications

authors： Takai D,Inoue K,Shisa H,Kagawa Y,Hayashi J

更新日期：1995-12-14 00:00:00

abstract：:The preferred dye binding sites and the microenvironment of known nucleotide sequences within mitochondrial and plasmid pBR322 DNA was probed in a gross fashion with restriction endonucleases. The intercalating dyes, ethidium bromide and propidium iodide, do not inhibit a given restriction endonuclease equally at all ...

journal_title：Biochemical and biophysical research communications

authors： Soslau G,Pirollo K

更新日期：1983-09-15 00:00:00

abstract：:In the present report we analyze by reverse transcription (RT) and polymerase chain reaction (PCR) the expression of vasoactive intestinal peptide receptors (VIP-R) in rat thymocytes and peripheral T and B lymphocytes. We have obtained a specific VIP-R cDNA product of 311 bp identical in size to that obtained from lun...

journal_title：Biochemical and biophysical research communications

authors： Gomariz RP,Garrido E,Leceta J,Martinez C,Abalo R,Delgado M

更新日期：1994-09-30 00:00:00

abstract：:The conversion of the endogenous cellular prion protein to an abnormally folded isoform is a hallmark of transmissible spongiform encephalopathies. It occurs when a misfolded prion protein contacts the cellular PrP. Among the molecular partners suggested to be involved in the misfolding process, the glycosaminoglycans...

journal_title：Biochemical and biophysical research communications

authors： Martin R,Chantepie S,Chapuis J,Le-Duc A,Maftah A,Papy-Garcia D,Laude H,Petit JM,Gallet PF

更新日期：2011-10-28 00:00:00

abstract：:Extracellular deoxycytidine (CdR) was previously shown to be salvaged into water soluble [1] and also into lipidic [2] precursors of phospholipids in stimulated lymphocytes and in lymphoma cells [3]. In this paper we have described that non-dividing murine macrophages salvaged not only 5-3H-CdR but also tritiated thym...

journal_title：Biochemical and biophysical research communications

authors： Hrabák A,Spasokukotskaja T,Temesi A,Staub M

更新日期：1993-05-28 00:00:00

abstract：:Allelic forms of hGSTP1-1 which differ from each other by their catalytic properties and, structurally, by the amino acid(s) in position(s) 104 or (and) 113 are known to exist in human populations. The four possible isoforms of hGSTP1-1 with isoleucine or valine in position 104 and with alanine or valine in position 1...

journal_title：Biochemical and biophysical research communications

authors： Hu X,Xia H,Srivastava SK,Herzog C,Awasthi YC,Ji X,Zimniak P,Singh SV

更新日期：1997-09-18 00:00:00

abstract：:Ultraweak luminescence (uwCL) was coupled with electron spin resonance to study the reactions of 3 heterocyclic compounds (tryptophan, serotonin and imidazole) with peroxynitrite at pH 8.7. Tryptophan and serotonin reacted with emission of a flash peak of light (5 s) followed by a long-living light emission of +/- 80 ...

journal_title：Biochemical and biophysical research communications

authors： Mouithys-Mickalad A,Kohnen S,Deby C,Noels AF,Lamy M,Deby-Dupont G

更新日期：1999-06-07 00:00:00

abstract：:A primary cellular target of the clinical nitrogenous bisphosphonates is the isoprenoid biosynthetic pathway. Specifically these drugs inhibit the enzyme farnesyl pyrophosphate synthase and deplete cells of larger isoprenoids. Inhibition of this enzyme results in impaired processing of both farnesylated and geranylger...

journal_title：Biochemical and biophysical research communications

authors： Wiemer AJ,Tong H,Swanson KM,Hohl RJ

更新日期：2007-02-23 00:00:00

abstract：:The short-term incubation of HeLa cells in the presence of diferric transferrin or ferricyanide, which are reduced externally by the transplasma membrane reductase, produces a stoichiometric decrease in NADH and increase in NAD+, which is stimulated by insulin. The NADP/NADPH ratio does not change during 15 min incuba...

journal_title：Biochemical and biophysical research communications

authors： Navas P,Sun IL,Morré DJ,Crane FL

更新日期：1986-02-26 00:00:00

abstract：:Cultured human endothelial cells produce increased levels of PA-I when stimulated with IL-1. The stimulatory effect was elicited by both alpha (pI 5) and beta (pI 7) IL-1 molecules. The effect was both dose and time-dependent, plateau reached after 8 h. The PA-I measured in cell extracts was SDS-resistant with an appa...

journal_title：Biochemical and biophysical research communications

authors： Grames M,Breviario F,Pintucci G,Millet I,Dejana E,van Damme J,Donati MB,Mussoni L

更新日期：1986-09-14 00:00:00

abstract：:The role of small ras homologous GTP-binding proteins in the regulation of smooth muscle contractility has become increasingly apparent but there is still little information about the presence of these proteins in human uterine smooth muscle. Messenger RNAs for p21-activated protein kinase isoforms (PAK1, PAK2, and PA...

journal_title：Biochemical and biophysical research communications

authors： Moore F,Da Silva C,Wilde JI,Smarason A,Watson SP,López Bernal A

更新日期：2000-03-16 00:00:00

abstract：:Hepatic fibrosis can be considered as wound healing process in response to hepatocellular injury. Activation of hepatic stellate cells (HSCs) is a key event of hepatic fibrosis since activated HSCs are the cellular source of enhanced extracellular matrix deposition, and reversion of liver fibrosis is accompanied by cl...

journal_title：Biochemical and biophysical research communications

authors： Valletta D,Czech B,Thasler WE,Müller M,Bosserhoff AK,Hellerbrand C

更新日期：2012-09-28 00:00:00

abstract：:The repair-associated gene XRCC1 was previously cloned by complementing the hamster mutant EM9, which has a high rate of spontaneous SCE and hypersensitivity to DNA damaging agents. In analyzing XRCC1 gene expression, similar levels of steady-state mRNA were found in normal cells, Bloom's syndrome cells with altered S...

journal_title：Biochemical and biophysical research communications

authors： Yoo H,Li L,Sacks PG,Thompson LH,Becker FF,Chan JY

更新日期：1992-07-31 00:00:00

abstract：:Recent environmental sampling around a landfill site in the UK demonstrated that unidentified xenoestrogens were present at higher levels than control sites; that these xenoestrogens were capable of super-activating (resisting ligand-dependent antagonism) the murine variant 2 ERβ and that the ionic liquid 1-octyl-3-me...

journal_title：Biochemical and biophysical research communications

authors： Leitch AC,Lakey AF,Hotham WE,Agius L,Kass GEN,Blain PG,Wright MC

更新日期：2018-09-10 00:00:00

abstract：:The isolation of human adrenal capillary endothelial (HACE) cells without resort to fluorescence activated cell sorting is described, together with their properties in culture. HACE cells were isolated by plating collagenase digests at high dilution in the presence of endothelial cell growth supplement, followed by cl...

journal_title：Biochemical and biophysical research communications

authors： Fawcett J,Harris AL,Bicknell R

更新日期：1991-01-31 00:00:00

abstract：:Tooth and bone are major tissues involved in physiological calcification in the body, and they use similar molecular pathways for development, homeostasis, and regeneration. Harmine (HMN) is a natural small compound that stimulates osteoblast differentiation in vitro and in vivo. Here we examined the biological effect...

journal_title：Biochemical and biophysical research communications

authors： Fujiwara N,Lee JW,Kumakami-Sakano M,Otsu K,Woo JT,Iseki S,Ota MS

更新日期：2018-03-11 00:00:00

abstract：:The extracellular microenvironment plays a key role in regulation of cellular functions and growth control. We show here that membrane-type 1 matrix metalloproteinase (MT1-MMP) acts as a growth promoter in confluent culture. When MT1-MMP was silenced in HT1080 fibrosarcoma cells, cells created three dimensional (3D) f...

journal_title：Biochemical and biophysical research communications

authors： Takino T,Guo L,Domoto T,Sato H

更新日期：2013-07-05 00:00:00

abstract：:Earlier investigations have shown that (a) antibodies against a carrier-coupled 20-residue synthetic peptide (C-20), (200)HACQKKLLKFEALQQEEGEE(219), corresponding to the C-terminal partially helical sequence of chicken riboflavin carrier protein (RCP; 219 AA) curtail pregnancy in mammals and (b) helix stabilization by...

journal_title：Biochemical and biophysical research communications

authors： Subramanian S,Karande AA,Adiga PR

更新日期：2001-09-14 00:00:00

abstract：:The effects of omeprazole on developing rat stomach mucosa were investigated. Infant rats were given subcutaneous injections of either omeprazole (25 mg/kg body weight/day) or vehicle once a day from the day after birth. As a result, omeprazole caused an elevation of mucosal pH and suppressed an increase in mucosal pe...

journal_title：Biochemical and biophysical research communications

authors： Kakei N,Ichinose M,Tsukada S,Tatematsu M,Tezuka N,Furihata C,Yahagi N,Matsushima M,Miki K,Kurokawa K

更新日期：1993-11-30 00:00:00

abstract：:Recently, copper (Cu) was found to be unusually accumulated, suggesting the induction of metallothionein (MT) in the liver of LEC rats (Long-Evans rats with a cinnamon-like coat color), which develop spontaneous jaundice with hereditary hepatitis. Thus, the direct relationship between the unusual Cu accumulation and t...

journal_title：Biochemical and biophysical research communications

authors： Sakurai H,Kamada H,Fukudome A,Kito M,Takeshima S,Kimura M,Otaki N,Nakajima K,Kawano K,Hagino T

更新日期：1992-06-15 00:00:00

abstract：:In this study, an endogenous factor(s) involved in the suppression of the induction of CYP1A1 was studied. Analyzing the sequences, we found that the sequence of xenobiotic responsive element (XRE) in the upstream region of the human CYP1A1 gene was overlapped with that of the upstream stimulatory factor 1 (USF1)-bind...

journal_title：Biochemical and biophysical research communications

authors： Takahashi Y,Nakayama K,Itoh S,Kamataki T

更新日期：1997-11-17 00:00:00

abstract：:Cullin-RING ligases (CRLs) regulate diverse cellular functions such as cell cycle progression and cytokine signaling by ubiquitinating key regulatory proteins. The activity of CRLs is controlled by Nedd8 modification of the cullin subunits. Recent reports have suggested that CAND1, which specifically binds to unmodifi...

journal_title：Biochemical and biophysical research communications

authors： Min KW,Kwon MJ,Park HS,Park Y,Yoon SK,Yoon JB

更新日期：2005-09-02 00:00:00