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Harmine promotes molar root development via SMAD1/5/8 phosphorylation.

Abstract：

:Tooth and bone are major tissues involved in physiological calcification in the body, and they use similar molecular pathways for development, homeostasis, and regeneration. Harmine (HMN) is a natural small compound that stimulates osteoblast differentiation in vitro and in vivo. Here we examined the biological effect of HMN on the postnatal development of molar tooth roots and periodontal tissues. HMN supported the formation of tooth roots and periodontal tissues in developing tooth germs. In tooth germ organ culture, HMN promoted the elongation of Hertwig's epithelial root sheath (HERS) and stimulated cell proliferation in HERS and dental follicle-derived tissues, including dental papillae and dental follicles. HMN stimulated cell proliferation and cell movement of HERS-derived cells without mesenchymal cells in vitro and directly induced the phosphorylation of SMAD1/5/8 protein in HERS-derived cells. Our results indicated that HMN was the first natural small compound to stimulate postnatal development of tooth germs.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Fujiwara N,Lee JW,Kumakami-Sakano M,Otsu K,Woo JT,Iseki S,Ota MS

doi

10.1016/j.bbrc.2017.12.062

subject

Has Abstract

pub_date

2018-03-11 00:00:00

pages

924-929

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(17)32456-7

journal_volume

497

pub_type

杂志文章

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