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Enhancement by interleukin-1 (IL-1) of plasminogen activator inhibitor (PA-I) activity in cultured human endothelial cells.

Abstract：

:Cultured human endothelial cells produce increased levels of PA-I when stimulated with IL-1. The stimulatory effect was elicited by both alpha (pI 5) and beta (pI 7) IL-1 molecules. The effect was both dose and time-dependent, plateau reached after 8 h. The PA-I measured in cell extracts was SDS-resistant with an apparent m.w. of 53 Kd and inhibited both tissue-type plasminogen activator (t-PA) and urokinase (UK). No change in t-PA antigen level was detected with any of the IL-1 preparations tested.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Grames M,Breviario F,Pintucci G,Millet I,Dejana E,van Damme J,Donati MB,Mussoni L

doi

10.1016/s0006-291x(86)80050-x

subject

Has Abstract

pub_date

1986-09-14 00:00:00

pages

720-7

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(86)80050-X

journal_volume

139

pub_type

杂志文章

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