当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Involvement of Sonic hedgehog in the cell growth of LK-2 cells, human lung squamous carcinoma cells.

Involvement of Sonic hedgehog in the cell growth of LK-2 cells, human lung squamous carcinoma cells.

Abstract：

:Mutation of the Patched gene has been detected in human inherited basal cell nevus syndrome (BCNS) and sporadic basal cell carcinomas (BCC), suggesting a strong relation between a Sonic hedgehog-Patched signal and cell proliferation. In the present study, we demonstrate that Sonic hedgehog is expressed in human lung squamous carcinoma (LK-2 and EBC-1) and some adenocarcinoma cell lines. The expression of Sonic hedgehog is also detected in the human lung squamous carcinoma tissues, but not in the normal lung tissue of the same patient. The N-terminal region of Sonic hedgehog stimulates the incorporation of BrdU into LK-2 cells and stimulates their cell growth, while anti-Shh-N inhibits their cell growth. These results suggest that a Sonic hedgehog signal is involved in the cell growth of LK-2 cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Fujita E,Khoroku Y,Urase K,Tsukahara T,Momoi MY,Kumagai H,Takemura T,Kuroki T,Momoi T

doi

10.1006/bbrc.1997.7262

subject

Has Abstract

pub_date

1997-09-18 00:00:00

pages

658-64

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(97)97262-4

journal_volume

238

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • HIV-1 gp120-induced apoptosis in the rat neocortex involves enhanced expression of cyclo-oxygenase type 2 (COX-2).

    abstract：:The effect of subchronic intracerebroventricular (i.c.v.) injection of the human immunodeficiency virus type 1 (HIV-1) recombinant protein gp120 (100 ng, given daily for up to 7 consecutive days) on cyclooxygenase type 2 (COX-2) expression was studied by immunohistochemistry in the brain of adult rats. In comparison t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8321

    authors： Bagetta G,Corasaniti MT,Paoletti AM,Berliocchi L,Nisticò R,Giammarioli AM,Malorni W,Finazzi-Agrò A

    更新日期：1998-03-27 00:00:00

  • Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate.

    abstract：:By its antioxidant effect, molecular hydrogen gas (H2) was reported to protect organs from tissue damage induced by ischemia reperfusion. To evaluate its anti-inflammatory effects, we established a mouse model of human inflammatory bowel disease (IBD) by supplying mice with water containing (1) dextran sodium sulfate ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.05.117

    authors： Kajiya M,Silva MJ,Sato K,Ouhara K,Kawai T

    更新日期：2009-08-14 00:00:00

  • Structure and chromosomal locus of the mouse gene encoding a cerebellar Purkinje cell-specific helix-loop-helix factor Hes-3.

    abstract：:HES-3 is a cerebellar Purkinje cell-specific helix-loop-helix factor structurally related to the products of the Drosophila hairy and Enhancer of split genes. Here, we report the nucleotide sequence and chromosomal locus of the mouse Hes-3 gene. This gene consists of four exons and the exon-intron boundaries are well ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2224

    authors： Sakagami T,Sakurada K,Sakai Y,Watanabe T,Nakanishi S,Kageyama R

    更新日期：1994-08-30 00:00:00

  • Differential regulation of cyclin-dependent kinase inhibitors in neuroblastoma cells.

    abstract：:Gastrin-releasing peptide (GRP) and its receptor (GRP-R) are highly expressed in undifferentiated neuroblastoma, and they play critical roles in oncogenesis. We previously reported that GRP activates the PI3K/AKT signaling pathway to promote DNA synthesis and cell cycle progression in neuroblastoma cells. Conversely, ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.04.023

    authors： Qiao L,Paul P,Lee S,Qiao J,Wang Y,Chung DH

    更新日期：2013-05-31 00:00:00

  • A chemically defined culture medium containing Rho kinase inhibitor Y-27632 for the fabrication of stratified squamous epithelial cell grafts.

    abstract：:With the development of a culture method for stratified squamous epithelial cells, tissue-engineered epithelial cell sheets have been successfully applied as clinical cell grafts. However, the implementation of these cell sheets without the use of any animal-derived materials is highly desirable. In this study, Rho-as...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.02.120

    authors： Aslanova A,Takagi R,Yamato M,Okano T,Yamamoto M

    更新日期：2015-05-01 00:00:00

  • Different phosphorylation rates among vertebrate cone visual pigments with different spectral sensitivities.

    abstract：:Cone photoreceptor subtypes having different spectral sensitivities exhibit different recovery kinetics in their photoresponses in some vertebrates. Phosphorylation by G protein-coupled receptor kinase (GRK) is essential for the rapid inactivation of light-activated visual pigment, which is the rate-limiting step of t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.09.118

    authors： Tsutsui K,Tachibanaki S,Shimauchi-Matsukawa Y,Shichida Y,Kawamura S

    更新日期：2013-11-01 00:00:00

  • ATP antagonizes the crowding-induced destabilization of the human eye-lens protein γS-crystallin.

    abstract：:In lens, αβγ-crystallins accounting for ∼90% of ocular proteins with concentrations >400 mg/ml need to remain soluble for the whole life-span and their aggregation can lead to cataract. Mysteriously, despite being a metabolically-quiescent organ, lens maintains ATP concentrations of 3-7 mM. Very recently, ATP was prop...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.04.014

    authors： He Y,Kang J,Song J

    更新日期：2020-06-11 00:00:00

  • Clonorchis sinensis-derived total protein attenuates airway inflammation in murine asthma model by inducing regulatory T cells and modulating dendritic cell functions.

    abstract：:Asthma is characterized by Th2-mediated inflammation, resulting in airway hyperresponsiveness (AHR) through airway remodeling. Recent epidemiological and experimental reports have suggested an inverse relationship between the development of allergy and helminth infections. Infection by Clonorchis sinensis, a liver flu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.03.102

    authors： Jeong YI,Kim SH,Ju JW,Cho SH,Lee WJ,Park JW,Park YM,Lee SE

    更新日期：2011-04-22 00:00:00

  • Differential regulation of splicing, localization and stability of mammalian ARD1235 and ARD1225 isoforms.

    abstract：:ARD1 protein is a mammalian gene product homologous to a yeast Ard1p (Arrest defective 1 protein) acetyltransferase. Although two alternative splicing products of ARD1, ARD1(235) and ARD1(225), were reported in mouse, only ARD1(235) orthologue was reported in humans. Here we show that ARD1(225) is not expressed in hum...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.11.131

    authors： Chun KH,Cho SJ,Choi JS,Kim SH,Kim KW,Lee SK

    更新日期：2007-02-02 00:00:00

  • Beta-1,4-galactosyltransferase and lactose synthase: molecular mechanical devices.

    abstract：:Recent structural investigations on the beta-1,4-galactosyltransferase-1 (Gal-T1) and lactose synthase (LS) have revealed that they are akin to an exquisite mechanical device with two well-coordinated flexible loops that are contained within the Gal-T1 catalytic domain. The smaller one has a Trp residue (Trp314) flank...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1006/bbrc.2002.6506

    authors： Ramakrishnan B,Boeggeman E,Qasba PK

    更新日期：2002-03-15 00:00:00

  • A regulatory role of Kruppel-like factor 4 in endothelial argininosuccinate synthetase 1 expression in response to laminar shear stress.

    abstract：:Endothelial argininosuccinate synthetase 1 (ASS1) regulates the provision of l-arginine to nitric oxide synthase 3 (NOS3). Previous studies demonstrated that endothelial ASS1 expression was induced by laminar shear stress (LSS) and that this enzyme plays a role in maintaining anti-inflammatory microenvironments throug...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.03.016

    authors： Mun GI,Boo YC

    更新日期：2012-04-06 00:00:00

  • Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme.

    abstract：:Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, and its N-terminus plays a critical role in the intracellular stability of the enzyme. In the present study, we investigated the mechanism by which the N-terminal region of TH affects this stability. TH molecules phosphorylated at the...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.03.020

    authors： Nakashima A,Mori K,Kaneko YS,Hayashi N,Nagatsu T,Ota A

    更新日期：2011-04-08 00:00:00

  • Purification and kinetic characterization of equine infectious anemia virus reverse transcriptase.

    abstract：:The reverse transcriptase of Equine Infectious Anemia Virus (EIAV) was partially purified from virus particles and appeared to be a heterodimer with subunit molecular masses of 70 kdal and 59 kdal. The polymerase activity of this enzyme had an absolute requirement for a divalent cation, preferring Mg++ over Mn++. Addi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)81346-4

    authors： Thomas DA,Furman PA

    更新日期：1991-11-14 00:00:00

  • Antiviral potency of adenosine analogues: correlation with inhibition of S-adenosylhomocysteine hydrolase.

    abstract：:For a series of adenosine analogues a close correlation (r = 0.986) was found between their antiviral potency (against vesicular stomatitis virus) and their inhibitory effects (Ki/Km) on S-adenosylhomocysteine (AdoHcy) hydrolase; thus, in order of increasing inhibitory potency for both virus replication and AdoHcy hyd...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91438-x

    authors： De Clercq E,Cools M

    更新日期：1985-05-31 00:00:00

  • Mitochondrial localization of fission yeast manganese superoxide dismutase is required for its lysine acetylation and for cellular stress resistance and respiratory growth.

    abstract：:Manganese-dependent superoxide dismutase (MnSOD) is localized in the mitochondria and is important for oxidative stress resistance. Although transcriptional regulation of MnSOD has been relatively well studied, much less is known about the protein's posttranslational regulation. In budding yeast, MnSOD is activated af...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.01.103

    authors： Takahashi H,Suzuki T,Shirai A,Matsuyama A,Dohmae N,Yoshida M

    更新日期：2011-03-04 00:00:00

  • Association of Shc, Cbl, Grb2, and Sos following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin in primary rat hepatocytes.

    abstract：:c-Src kinases and p21 Ras are known to be implicated in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated signal transduction. However, the effects of TCDD on the molecular interaction of adaptor complex in the protein tyrosine kinase signaling cascade have not been reported. The present study is designed to clarify...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.9816

    authors： Park R,Kim DH,Kim MS,So HS,Chung HT,Kwon KB,Ryu DG,Kim BR

    更新日期：1998-12-30 00:00:00

  • Stat3 is involved in control of MASP2 gene expression.

    abstract：:Little is known about determinants regulating expression of Mannan-binding lectin associated serine protease-2 (MASP-2), the effector component of the lectin pathway of complement activation. Comparative bioinformatic analysis of the MASP2 promoter regions in human, mouse, and rat, revealed conservation of two putativ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.10.114

    authors： Unterberger C,Hanson S,Klingenhoff A,Oesterle D,Frankenberger M,Endo Y,Matsushita M,Fujita T,Schwaeble W,Weiss EH,Ziegler-Heitbrock L,Stover C

    更新日期：2007-12-28 00:00:00

  • Inhibitory effect of porphyrins on the proliferation of mouse spleen lymphocytes in vitro.

    abstract：:The influence of various porphyrins (deuteroporphyrin IX, mesoporphyrin IX, protoporphyrin IX, hematoporphyrin) and two related compounds (hemin, biliverdin) on the spontaneous proliferation of mouse spleen lymphocytes has been estimated in vitro by the 3H-thymidine uptake assay. It has been found that porphyrins (end...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)90522-9

    authors： Stepien H,Kunert-Radek J,Stanisz A,Zerek-Melen G,Pawlikowski M

    更新日期：1991-01-15 00:00:00

  • Anti-diabetic and hypolipidemic effects of Sargassum yezoense in db/db mice.

    abstract：:Peroxisome proliferator-activated receptors (PPARs) have been considered to be desirable targets for metabolic syndrome, even though their specific agonists have several side effects including body weight gain, edema and tissue failure. Previously, we have reported in vitro effects of Sargassum yezoense (SY) and its i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.07.005

    authors： Kim SN,Lee W,Bae GU,Kim YK

    更新日期：2012-08-10 00:00:00

  • Senescence from glioma stem cell differentiation promotes tumor growth.

    abstract：:Glioblastoma (GBM) is a lethal brain tumor composed of heterogeneous cellular populations including glioma stem cells (GSCs) and differentiated non-stem glioma cells (NSGCs). While GSCs are involved in tumor initiation and propagation, NSGCs' role remains elusive. Here, we demonstrate that NSGCs undergo senescence and...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.01.071

    authors： Ouchi R,Okabe S,Migita T,Nakano I,Seimiya H

    更新日期：2016-02-05 00:00:00

  • C57BL/6JRj mice are protected against diet induced obesity (DIO).

    abstract：:The C57BL/6 (B6) is one of the oldest inbred mouse strains. It has been widely used as control strain in metabolism research for many decades. Preliminary data from our lab indicated that C57BL/6JRj mice are not responding to diet induced obesity. Therefore, the aim of this study was to compare the two different B6 su...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.12.008

    authors： Kern M,Knigge A,Heiker JT,Kosacka J,Stumvoll M,Kovacs P,Blüher M,Klöting N

    更新日期：2012-01-13 00:00:00

  • Sensitive detection of FGFR3 mutations in bladder cancer and urine sediments by peptide nucleic acid-mediated real-time PCR clamping.

    abstract：:Somatic mutations of the fibroblast growth factor receptor 3 (FGFR3) gene were detected by peptide nucleic acid (PNA)-mediated real-time PCR clamping. Mutation was detected in negative control containing only wild-type DNA due to a misincorporation of dNTPs to PNA binding sites when the amount of template DNA was decr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.08.092

    authors： Miyake M,Sugano K,Kawashima K,Ichikawa H,Hirabayashi K,Kodama T,Fujimoto H,Kakizoe T,Kanai Y,Fujimoto K,Hirao Y

    更新日期：2007-11-03 00:00:00

  • Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7.

    abstract：:Two genomic clones containing the 3'-end of CYP3A7, the whole 5'-flanking region plus the first exon of CYP3A5 were isolated from two different human genomic banks and sequenced. The 5'-flanking region of CYP3A5, from nucleotide -1 to -1434, was 60% and 59% similar with the corresponding regions of CYP3A4 and CYP3A7, ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2870

    authors： Jounaïdi Y,Guzelian PS,Maurel P,Vilarem MJ

    更新日期：1994-12-30 00:00:00

  • FoxA1 as a lineage-specific oncogene in luminal type breast cancer.

    abstract：:The forkhead transcription factor FoxA1 is thought to be involved in mammary tumorigenesis. However, the precise role of FoxA1 in breast cancer development is controversial. We examined expression of FoxA1 in 35 human breast cancer cell lines and compared it with that of ErbB2, a marker of poor prognosis in breast can...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.11.064

    authors： Yamaguchi N,Ito E,Azuma S,Honma R,Yanagisawa Y,Nishikawa A,Kawamura M,Imai J,Tatsuta K,Inoue J,Semba K,Watanabe S

    更新日期：2008-01-25 00:00:00

  • Differential phosphorylation of paxillin in response to surface-bound serum proteins during early osteoblast adhesion.

    abstract：:An early signaling event during the adhesion and spreading of cells is integrin-mediated tyrosine phosphorylation of the cytoskeletal adaptor protein paxillin and the non-receptor tyrosine kinase pp125(FAK) at focal contacts. To determine the influence of surface-charge and -adsorbed adhesion proteins on this signalin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5198

    authors： Sommerfeldt DW,McLeod KJ,Rubin CT,Hadjiargyrou M

    更新日期：2001-07-13 00:00:00

  • Exosomes expressing carbonic anhydrase 9 promote angiogenesis.

    abstract：:Exosomes or microvesicles that are secreted from cells are considered to play important roles in tumor microenvironment. Carbonic anhydrase 9 (CA9), which is induced by hypoxia-inducible factor 1 (HIF1) in response to hypoxia, is overexpressed in many types of cancer including renal cell carcinoma (RCC). We examined t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.08.107

    authors： Horie K,Kawakami K,Fujita Y,Sugaya M,Kameyama K,Mizutani K,Deguchi T,Ito M

    更新日期：2017-10-21 00:00:00

  • Direct interaction of the beta-domain of VHL tumor suppressor protein with the regulatory domain of atypical PKC isotypes.

    abstract：:VHL tumor suppressor protein contains two domains, alpha and beta. The alpha-domain is involved in the formation of a large protein complex suggested to be involved in ubiquitin-mediated protein degradation. However, the role of the beta-domain, which may recognize the target proteins for protein degradation, remains ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1347

    authors： Okuda H,Hirai S,Takaki Y,Kamada M,Baba M,Sakai N,Kishida T,Kaneko S,Yao M,Ohno S,Shuin T

    更新日期：1999-09-24 00:00:00

  • p73 regulates maintenance of neural stem cell.

    abstract：:p73, a member of the p53 family, is a transcription factor that plays a key role in many biological processes. In the present study, we show that TAp73 is expressed in neural stem cells (NSC) and its expression increases following their differentiation. NSC from p73 null mice have a reduced proliferative potential, to...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.10.087

    authors： Agostini M,Tucci P,Chen H,Knight RA,Bano D,Nicotera P,McKeon F,Melino G

    更新日期：2010-12-03 00:00:00

  • Purification of the yellow fluorescent protein from Vibrio fischeri and identity of the flavin chromophore.

    abstract：:A low molecular weight protein (approximately 25,000 D) exhibiting a yellow fluorescence emission peaking at approximately 540 nm was isolated from Vibrio fischeri (strain Y-1) and purified to apparent homogeneity. FMN is the chromophore, but it exhibits marked red shifts in both the absorption (lambda max = 380, 460 ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)90696-6

    authors： Macheroux P,Schmidt KU,Steinerstauch P,Ghisla S,Colepicolo P,Buntic R,Hastings JW

    更新日期：1987-07-15 00:00:00

  • Repair of psoralen interstrand cross-links in Xenopus laevis egg extracts is highly mutagenic.

    abstract：:The recognition and removal of interstrand cross-links is perhaps the least understood of all repair pathways in eukaryotic cells. We have shown previously that uncoupling of cross-links occurs in mammalian cell extracts and have identified a number of factors that mediate this process. However, we have not observed c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.08.042

    authors： Lu X,Zhang N,Vasquez K,Barton M,Legerski R

    更新日期：2005-10-14 00:00:00