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Stat3 is involved in control of MASP2 gene expression.

Abstract：

:Little is known about determinants regulating expression of Mannan-binding lectin associated serine protease-2 (MASP-2), the effector component of the lectin pathway of complement activation. Comparative bioinformatic analysis of the MASP2 promoter regions in human, mouse, and rat, revealed conservation of two putative Stat binding sites, termed StatA and StatB. Site directed mutagenesis specific for these sites was performed. Transcription activity was decreased 5-fold when StatB site was mutated in the wildtype reporter gene construct. Gel retardation and competition assays demonstrated that proteins contained in the nuclear extract prepared from HepG2 specifically bound double-stranded StatB oligonucleotides. Supershift analysis revealed Stat3 to be the major specific binding protein. We conclude that Stat3 binding is important for MASP2 promoter activity.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Unterberger C,Hanson S,Klingenhoff A,Oesterle D,Frankenberger M,Endo Y,Matsushita M,Fujita T,Schwaeble W,Weiss EH,Ziegler-Heitbrock L,Stover C

doi

10.1016/j.bbrc.2007.10.114

subject

Has Abstract

pub_date

2007-12-28 00:00:00

pages

1022-5

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)02295-4

journal_volume

364

pub_type

杂志文章

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