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An in vitro evaluation of the effects of homocysteine thiolactone on key steps of angiogenesis and tumor invasion.

Abstract：

:Homocysteine thiolactone is a highly reactive homocysteine derivative that can react easily with proteins. Protein homocysteinylation has been suggested as a possible mechanism underlying the pathological consequences of impaired homocysteine metabolism. Homocysteine inhibits key steps of angiogenesis and tumor invasion. It can be hypothesized that homocysteine thiolactone could mimic the described anti-angiogenic and anti-invasive effects of homocysteine. Therefore, we studied the effects of homocysteine thiolactone on different key steps of angiogenesis and tumor invasion, using model endothelial and tumor cell lines. This study demonstrates that homocysteine thiolactone, in high contrast to homocysteine, is not an anti-angiogenic compound. Furthermore, our results suggest that homocysteine thiolactone could behave as a pro-angiogenic compound.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Martínez-Poveda B,Chavarría T,Sánchez-Jiménez F,Quesada AR,Medina MA

doi

10.1016/j.bbrc.2003.10.044

subject

Has Abstract

pub_date

2003-11-21 00:00:00

pages

649-53

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006291X03021296

journal_volume

311

pub_type

杂志文章

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