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Differences in two mice strains on kainic acid-induced amygdalar seizures.

Abstract：

:Seizure susceptibility and neurodegeneration induced by microinjection of kainic acid (KA) into the left amygdala (LA) in C57BL/6 and FVB/N mouse strains were compared. Mice were administered 0.5 microg of KA into the LA. Electroencephalograms (EEGs) and behavior were monitored for 48 h after KA microinjection. Neuronal cell damages in the CA1 and CA3 regions of hippocampus were assessed at 2 and 48 h after KA microinjection. We demonstrated that the FVB/N mice showed longer duration of seizure activity than the C57BL/6 mice in EEGs and behavioral observation. The C57BL/6 mice were resistant to neurodegeneration while the FVB/N mice were vulnerable as measured 2 and 48 h after KA microinjection. These differences might be associated with genetic background.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kasugai M,Akaike K,Imamura S,Matsukubo H,Tojo H,Nakamura M,Tanaka S,Sano A

doi

10.1016/j.bbrc.2007.04.067

subject

Has Abstract

pub_date

2007-06-15 00:00:00

pages

1078-83

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)00799-1

journal_volume

357

pub_type

杂志文章

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