Anticancer drug irinotecan inhibits homomeric 5-HT3A and heteromeric 5-HT3AB receptor responses.

abstract：:Four monoclonal antibodies, M-T21, M-T32, M-T41 and UM4D4, which belong to the new CDw 60 cluster of antibodies specific for a subpopulation of human T-lymphocytes, were found to bind mainly to acetylated forms of ganglioside GD3. After O-deacetylation of the antigen, binding was reduced ("M-T"-antibodies) or abolishe...

journal_title：Biochemical and biophysical research communications

authors： Kniep B,Peter-Katalinić J,Flegel W,Northoff H,Rieber EP

更新日期：1992-09-30 00:00:00

abstract：:Approximately 80% of ovarian cancer (OC) is diagnosed at late stages, and most patients die within 5 years of diagnosis due to recurrence or drug resistance. Novel treatments are required to improve patient survival. Immune therapy against cancer is promising; however, therapeutic vaccination has been limited by the i...

journal_title：Biochemical and biophysical research communications

authors： Yu W,Qu H,Cao G,Liu C,Deng H,Zhang Z

更新日期：2017-12-09 00:00:00

abstract：:Previous studies have suggested that 1,25(OH)2D3, the active form of vitamin D3, may increase the survival of bone-forming osteoblasts through an inhibition of apoptosis. On the other hand, vitamin D3 has also been shown to trigger apoptosis in human cancer cells, including osteosarcoma-derived cell lines. In the pres...

journal_title：Biochemical and biophysical research communications

authors： Witasp E,Gustafsson AC,Cotgreave I,Lind M,Fadeel B

更新日期：2005-05-13 00:00:00

abstract：:MazF is a sequence-specific endoribonuclease or mRNA interferase, which cleaves RNA at a specific sequence. Since the expression of a specific gene or a group of specific genes can be regulated by MazF, expanding the repertoire of recognition sequences by MazF mRNA interferases is highly desirable for biotechnological...

journal_title：Biochemical and biophysical research communications

authors： Ishida Y,Inouye K,Ming O,Inouye M

更新日期：2019-10-20 00:00:00

abstract：:Cone photoreceptor subtypes having different spectral sensitivities exhibit different recovery kinetics in their photoresponses in some vertebrates. Phosphorylation by G protein-coupled receptor kinase (GRK) is essential for the rapid inactivation of light-activated visual pigment, which is the rate-limiting step of t...

journal_title：Biochemical and biophysical research communications

authors： Tsutsui K,Tachibanaki S,Shimauchi-Matsukawa Y,Shichida Y,Kawamura S

更新日期：2013-11-01 00:00:00

abstract：:Vascular remodeling characterized by hyperproliferative neointima formation is an unfavorable repair process that is triggered by vascular damage. This process is characterized by an increased local inflammatory and proliferative response that critically involves the pro-inflammatory cytokine interleukin-1β (IL-1β). I...

journal_title：Biochemical and biophysical research communications

authors： Schlaweck S,Zimmer S,Struck R,Bartok E,Werner N,Bauernfeind F,Latz E,Nickenig G,Hornung V,Ghanem A

更新日期：2011-08-05 00:00:00

abstract：:Armadillo proteins are involved in providing strength and support to cells and tissues, nuclear transport, and transcriptional activation. In this report, we describe the identification and characterisation of the cDNA of the desmosomal armadillo protein plakophilin 2 in zebrafish. The 2448bp coding sequence encodes a...

journal_title：Biochemical and biophysical research communications

authors： Moriarty MA,Martin ED,Byrnes L,Grealy M

更新日期：2008-02-29 00:00:00

abstract：:To understand the structural basis in the hormone-dependent transcriptional regulation of human beta 1 thyroid hormone receptor (h-TR beta 1), we characterized the region which interacted with the thyroid hormone, 3,3',5-triiodo-L-thyronine (T3). Using the hormone binding domain of h-TR beta 1 (K206-D461) as an immuno...

journal_title：Biochemical and biophysical research communications

authors： Bhat MK,McPhie P,Cheng SY

更新日期：1995-05-16 00:00:00

abstract：:Cyclin D1 (CCND1) is a key regulatory protein at the G1/S checkpoint of the cell cycle. The purpose of our study was to assess the role of CCND1 genotypes influencing the age of onset of oncogenic virus-associated neoplasia. We conducted a hospital-based case-control study of 581 individuals, including 247 controls an...

journal_title：Biochemical and biophysical research communications

authors： Catarino R,Pereira D,Breda E,Coelho A,Matos A,Lopes C,Medeiros R

更新日期：2008-05-23 00:00:00

abstract：:Here we demonstrate that the semi-synthetic flavonoid ayanin diacetate induces cell death selectively in leukemia cells without affecting the proliferation of normal lymphocytes. Incubation of human leukemia cells with ayanin diacetate induced G(2)-M phase cell cycle arrest and apoptosis which was prevented by the non...

journal_title：Biochemical and biophysical research communications

authors： Marrero MT,Estévez S,Negrín G,Quintana J,López M,Pérez FJ,Triana J,León F,Estévez F

更新日期：2012-11-09 00:00:00

abstract：:Hippocampus is one of the most vulnerable tissues to glucocorticoid (GC). In the present study, we demonstrate that dexamethasone (DEX), a synthetic GC, induces apoptotic cell death in hippocampal progenitor HiB5 cells without any additional insult. Interestingly, expression of 27-kDa heat shock protein (HSP27) was ma...

journal_title：Biochemical and biophysical research communications

authors： Son GH,Geum D,Chung S,Park E,Lee KH,Choi S,Kim K

更新日期：2005-12-30 00:00:00

abstract：:The disruption of intestinal mucosal immune tolerance can lead to the development of intestinal immune diseases such as food allergy (FA). Regulatory T cells (Tregs) in the mucosa play a critical role in maintaining peripheral immune tolerance in the intestine, and retinoic acid (RA) is absolutely required for the ind...

journal_title：Biochemical and biophysical research communications

authors： Yamamoto T,Matsunami E,Komori K,Hayashi S,Kadowaki M

更新日期：2019-08-27 00:00:00

abstract：:GTP gamma S-dependent phospholipase D (PLD) activity time-dependently increased during differentiation of rat C6 glioma cells to astrocytic phenotypes induced by dibutyryl cyclic AMP (dbcAMP)/theophylline. The changes in PLD mRNA level were examined by reverse transcriptase-polymerase chain reaction (RT-PCR) method us...

journal_title：Biochemical and biophysical research communications

authors： Yoshimura S,Nakashima S,Ohguchi K,Sakai H,Shinoda J,Sakai N,Nozawa Y

更新日期：1996-08-14 00:00:00

abstract：:Isolation of pure acinar cells of the rat pancreas was achieved employing counterflow sedimentation filtration technique (CSFT). The preparation of purified acinar cells contained an occasional red blood cell (RBC, 200:1) with total absence of endocrine and duct cells. A significant stimulation of amylase secretion fr...

journal_title：Biochemical and biophysical research communications

authors： Bandisode MS,Singh M

更新日期：1985-05-31 00:00:00

abstract：:Plants use specialized root outgrowths, termed root hairs, to enhance acquisition of nutrients and water, help secure anchorage, and facilitate interactions with soil microbiome. One of the major regulators of this process is GLABRA2 (GL2), a transcriptional repressor of root hair differentiation. However, regulation ...

journal_title：Biochemical and biophysical research communications

authors： Wu R,Citovsky V

更新日期：2017-07-01 00:00:00

abstract：:The partitioning of the acylenzyme acetyl-(Gly)n-Phe(NO2)-chymotrypsin (n = 0,1,2) to peptide and peptide acid is observed spectrophotometrically. Values of partitioning ratios for various nucleophiles are calculated from the spectral data. They are a measure for the "true" nucleophile reactivity and are useful in the...

journal_title：Biochemical and biophysical research communications

authors： Petkov DD,Stoineva I

更新日期：1984-01-13 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) enhances the mitogenic response to epidermal growth factor (EGF) in hepatocytes, but the underlying mechanisms are not clear. We previously observed that PGE(2) upregulates EGF-induced signalling in the MEK/ERK and PI3K/Akt pathways in hepatocytes. Other investigations have indicated that E...

journal_title：Biochemical and biophysical research communications

authors： Ødegård J,Aasrum M,Tveteraas IH,Bharath SP,Sandnes D,Christoffersen T

更新日期：2012-05-04 00:00:00

abstract：:The soil fungus Mucor genevensis was shown to convert exogenous arachidonic acid to the oxylipin 3-hydroxy-5Z,8Z-tetradecadienoic acid (3-HTDE) as determined by gas chromatography/mass spectrometry. This metabolite was only found in the aqueous supernatant together with free linoleic acid, but not in the final fungal ...

journal_title：Biochemical and biophysical research communications

authors： Pohl CH,Botha A,Kock JL,Coetzee DJ,Botes PJ,Schewe T,Nigam S

更新日期：1998-12-30 00:00:00

abstract：:We have identified by protein sequencing the precursor of beta protein in newborn rat brain. A rabbit antibody was raised against a synthetic peptide corresponding to the carboxyl-terminal 30 residues (666-695) of the putative beta-amyloid protein precursor (Kang et al. 1987). The antiserum recognized multiple bands a...

journal_title：Biochemical and biophysical research communications

authors： Takio K,Hasegawa M,Titani K,Ihara Y

更新日期：1989-05-15 00:00:00

abstract：:Treatment with double-stranded RNA (dsRNA) has been shown to interfere with the function of specific genes in various invertebrate species. However, it has not yet been reported that this technique can be applied to vertebrates as well. We have investigated whether dsRNA treatment will inhibit gene function in zebrafi...

journal_title：Biochemical and biophysical research communications

authors： Wargelius A,Ellingsen S,Fjose A

更新日期：1999-09-16 00:00:00

abstract：:Erbin localizes at the basolateral membrane to regulate cell junctions and polarity in epithelial cells. Dysregulation of Erbin has been implicated in tumorigenesis, and yet it is still unclear if and how disrupted Erbin regulates the biological behavior of cancer cells. We report here that depletion of Erbin leads to...

journal_title：Biochemical and biophysical research communications

authors： Huang H,Song Y,Wu Y,Guo N,Ma Y,Qian L

更新日期：2015-07-31 00:00:00

abstract：:Partially purified trehalose phosphorylase (EC 2.4.1.64) from Euglena gracilis SM-ZK was inhibited by fructose 2,6-bisphosphate in both synthetic and degradative directions. Ki value for trehalose phosphorolysis was 1.2 microM and that for trehalose synthesis was 0.5 microM. Functions of fructose 2,6-bisphosphate in E...

journal_title：Biochemical and biophysical research communications

authors： Miyatake K,Kuramoto Y,Kitaoka S

更新日期：1984-08-16 00:00:00

abstract：:Gemin4 is a ubiquitously expressed multifunctional protein that is involved in U snRNP assembly, apoptosis, nuclear/cytoplasmic transportation, transcription, and RNAi pathways. Gemin4 is one of the core components of the Gemin-complex, which also contains survival motor neuron (SMN), the seven Gemin proteins (Gemin2-...

journal_title：Biochemical and biophysical research communications

authors： Lorson MA,Dickson AM,Shaw DJ,Todd AG,Young EC,Morse R,Wolstencroft C,Lorson CL,Young PJ

更新日期：2008-10-10 00:00:00

abstract：:The aorta-gonad-mesonephros (AGM) region is involved in the generation and maintenance of the first definitive hematopoietic stem cells (HSCs). A mouse AGM-derived cell line, AGM-S3, was shown to support the development of HSCs. To elucidate the molecular mechanisms regulating early hematopoiesis, we obtained subclone...

journal_title：Biochemical and biophysical research communications

authors： Nagao K,Ohta T,Hinohara A,Tahara T,Hagiwara T,Maeda Y,Yoneya T,Sohma Y,Heike T,Nakahata T,Inagaki Y,Nishikawa M

更新日期：2008-12-05 00:00:00

abstract：:The lipid phosphatase SHIP2 (SH2 domain containing inositol 5-phosphatase 2) has recently been shown to be a potent negative regulator of insulin signaling and insulin sensitivity in vivo. We show here that SHIP2 is expressed in Chinese hamster ovary cells overexpressing the insulin receptor (CHO-IR cells) and tyrosin...

journal_title：Biochemical and biophysical research communications

authors： Blero D,De Smedt F,Pesesse X,Paternotte N,Moreau C,Payrastre B,Erneux C

更新日期：2001-04-06 00:00:00

abstract：:In many apoptotic cells, phosphatidylserine (PS), that is normally restricted to the inner membrane layer, is externalized and subsequently recognized by phagocytes. However, it has been unclear whether PS externalization is sufficient for phagocytosis induction. In a cultured cell line undergoing Fas-mediated apoptos...

journal_title：Biochemical and biophysical research communications

authors： Shiratsuchi A,Osada S,Kanazawa S,Nakanishi Y

更新日期：1998-05-19 00:00:00

abstract：:On the basis of the well-known effect of ethanol poisoning on the prooxidant/antioxidant balance of human and rodent liver we tested the response of the mitochondrial manganese-containing superoxide dismutase (MnSOD) in the liver of rats following an acute ethanol load or chronically intoxicated with an alcohol-supple...

journal_title：Biochemical and biophysical research communications

authors： Koch OR,De Leo ME,Borrello S,Palombini G,Galeotti T

更新日期：1994-06-30 00:00:00

abstract：:Translational control by specific eIF2alpha phosphorylation on serine 51 has been characterized in all eukaryotes with the significant exception of plants. In order to evaluate the capability of plant eIF2alpha to functionally control translation, the wild type (51S) and a nonphosphorylatable mutant (51A) of wheat eIF...

journal_title：Biochemical and biophysical research communications

authors： Chang LY,Yang WY,Roth D

更新日期：2000-12-20 00:00:00

abstract：:Arrhythmogenic right ventricular dysplasia/cardiomyopathy type 2 (ARVD2, OMIM 600996) and stress-induced polymorphic ventricular tachycardia (VTSIP, OMIM 604772) are two cardiac diseases causing juvenile sudden death, both associated with mutations in the RyR2 calcium channel. By using a quantitative yeast two-hybrid ...

journal_title：Biochemical and biophysical research communications

authors： Tiso N,Salamon M,Bagattin A,Danieli GA,Argenton F,Bortolussi M

更新日期：2002-12-13 00:00:00

abstract：:Oct4-Sox2-Nanog transcriptional networks are critical for the maintenance of embryonic stem (ES) cell self-renewal and induction of pluripotency. However, in transcription factor-induced reprogramming of somatic cells into induced pluripotent stem cells (iPSCs), Nanog is initially dispensable and Oct4 remains the sole...

journal_title：Biochemical and biophysical research communications

authors： Moon JH,Yun W,Kim J,Hyeon S,Kang PJ,Park G,Kim A,Oh S,Whang KY,Kim DW,Yoon BS,You S

更新日期：2013-02-15 00:00:00