A peplomycin-supersensitive cell line lacking activation of poly(adenosine diphosphate ribose) synthetase by peplomycin.

Abstract:

:In peplomycin-supersensitive Chinese hamster lung cells, the increase in poly(ADP-ribose) synthesizing activity following peplomycin treatment was significantly reduced as compared with the parental lung cells, suggesting that peplomycin-supersensitive lung cells may have some deficiency in DNA repair. On the contrary, peplomycin-supersensitive ovary cells, which undergo increased DNA damage induced by peplomycin, showed normally increased poly(ADP-ribose) polymerizing activity compared with the parental ovary cells. Relationship between poly(ADP-ribose) polymerase and peplomycin sensitivity was discussed.

authors

Ozawa S,Suzuki H,Yamaki H,Nishimura T,Tanaka N

doi

10.1016/s0006-291x(88)80504-7

subject

Has Abstract

pub_date

1988-03-30 00:00:00

pages

1305-11

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)80504-7

journal_volume

151

pub_type

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