Abstract:
:In peplomycin-supersensitive Chinese hamster lung cells, the increase in poly(ADP-ribose) synthesizing activity following peplomycin treatment was significantly reduced as compared with the parental lung cells, suggesting that peplomycin-supersensitive lung cells may have some deficiency in DNA repair. On the contrary, peplomycin-supersensitive ovary cells, which undergo increased DNA damage induced by peplomycin, showed normally increased poly(ADP-ribose) polymerizing activity compared with the parental ovary cells. Relationship between poly(ADP-ribose) polymerase and peplomycin sensitivity was discussed.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Ozawa S,Suzuki H,Yamaki H,Nishimura T,Tanaka Ndoi
10.1016/s0006-291x(88)80504-7subject
Has Abstractpub_date
1988-03-30 00:00:00pages
1305-11issue
3eissn
0006-291Xissn
1090-2104pii
S0006-291X(88)80504-7journal_volume
151pub_type
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