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Nuclear orphan receptor TLX affects gene expression, proliferation and cell apoptosis in beta cells.

Abstract：

:Nuclear orphan receptor TLX is an essential regulator of the growth of neural stem cells. However, its exact function in pancreatic islet cells is still unknown. In the present study, gene expression profiling analysis revealed that overexpression of TLX in beta cell line MIN6 causes suppression of 176 genes and upregulation of 49 genes, including a cadre of cell cycle, cell proliferation and cell death control genes, such as Btg2, Ddit3 and Gadd45a. We next examined the effects of TLX overexpression on proliferation, apoptosis and insulin secretion in MIN6 cells. Proliferation analysis using EdU assay showed that overexpression of TLX increased percentage of EdU-positive cells. Cell cycle and apoptosis analysis revealed that overexpression of TLX in MIN6 cells resulted in higher percentage of cells exiting G1 into S-phase, and a 58.8% decrease of cell apoptosis induced by 0.5 mM palmitate. Moreover, TLX overexpression did not cause impairment of insulin secretion. Together, we conclude that TLX is among factors capable of controlling beta cell proliferation and survival, which may serve as a target for the development of novel therapies for diabetes.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Shi X,Xiong X,Dai Z,Deng H,Sun L,Hu X,Zhou F,Xu Y

doi

10.1016/j.bbrc.2015.10.042

subject

Has Abstract

pub_date

2015-12-04 00:00:00

pages

387-93

issue

1-2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(15)30742-7

journal_volume

468

pub_type

杂志文章

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