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Induction of apoptosis and inhibition of cell growth by developmental regulator hTBX5.

Abstract：

:T box (Tbx) genes are a large family of transcription regulators that play critical roles in invertebrate and vertebrate development. Mutations in Tbx5 gene have been found to cause Holt-Oram syndrome (HOS) in humans. Partial dysfunction of TBX5 in mouse also causes HOS phenotype. Little is known about its molecular and cellular mechanism. Here, we report that ectopic expression of TBX5 inhibited colony formation, induced apoptosis, and decreased the growth rate of cells. The two point mutations in T domain and a truncated mutation in C-terminal found in human HOS patients produced TBX5 mutant proteins with a significantly reduction of colony suppression activity. Deletion of the DNA-binding domain, however, nearly completely abrogated its ability to suppress colony formation. These results reveal TBX5 as a new regulator of apoptosis and cell growth, suggesting a possible mechanism for Holt-Oram syndrome, and a potential reagent for controlling tumor growth.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

He ML,Chen Y,Peng Y,Jin D,Du D,Wu J,Lu P,Lin MC,Kung HF

doi

10.1016/s0006-291x(02)02142-3

subject

Has Abstract

pub_date

2002-09-20 00:00:00

pages

185-92

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X02021423

journal_volume

297

pub_type

杂志文章

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