Peptide mapping of the insulin-binding site of the 130-kDa subunit of the insulin receptor by means of a novel cleavable radioactive photoprobe.

abstract：:Here we report the finding of glycosylase activity in mammalian tissues to remove 8-hydroxyguanine residues from DNA. To detect this activity, a synthetic duplex DNA containing an 8-hydroxyguanine residue was used as the substrate, and before the product was analyzed by HPLC-electrochemical detection (ECD), 8-hydroxyg...

journal_title：Biochemical and biophysical research communications

authors： Lee YS,Lee HS,Park MK,Hwang ES,Park EM,Kasai H,Chung MH

更新日期：1993-11-15 00:00:00

abstract：:The PAX3 transcription factor is the key regulator of melanocyte development during embryogenesis and is also frequently found in melanoma cells. While PAX3 is known to regulate melanocyte differentiation, survival, proliferation and migration during development, it is not clear if its function is maintained in adult ...

journal_title：Biochemical and biophysical research communications

authors： Medic S,Rizos H,Ziman M

更新日期：2011-08-12 00:00:00

abstract：:A 64-year-old Japanese male suffering from very slowly progressive amyloidosis was studied by immunohistopathologic, mass spectrometric, and molecular genetic methods. After confirming the immunoreactivity of transthyretin (TTR) in the amyloid deposits using an anti-TTR polyclonal antibody, matrix-assisted laser desor...

journal_title：Biochemical and biophysical research communications

authors： Terazaki H,Ando Y,Misumi S,Nakamura M,Ando E,Matsunaga N,Shoji S,Okuyama M,Ideta H,Nakagawa K,Ishizaki T,Ando M,Saraiva MJ

更新日期：1999-10-22 00:00:00

abstract：:Transcription factor GATA-6 plays essential roles in developmental processes and tissue specific functions through regulation of gene expression. GATA-6 mRNA utilizes two Met-codons in frame as translational initiation codons. Deletion of the nucleotide sequence encoding the PEST sequence (Glu(31)-Cys(46)) between the...

journal_title：Biochemical and biophysical research communications

authors： Takada K,Obayashi K,Ohashi K,Ohashi-Kobayashi A,Nakanishi-Matsui M,Maeda M

更新日期：2014-10-03 00:00:00

abstract：:We showed previously that the neuropeptide, galanin, transiently and promptly increases the cytoplasmic concentration of Ca2+, [Ca2+]i, in insulin producing clonal RINm5F cells prior to a reduction in [Ca2+]i. We found that galanin (100 nM) transiently increased the [Ca2+]i in the presence of 15 mM glyceraldehyde and ...

journal_title：Biochemical and biophysical research communications

authors： Ahrén B

更新日期：1996-04-05 00:00:00

abstract：:Using baculoviral and bacterial systems, we expressed biologically active recombinant rat IL-13 and generated neutralizing rat IL-13 antiserum. Recombinant rat IL-13 produced by baculovirus-infected insect cells stimulated proliferation of TF-1 premyeloid cell line and induced expression of 15-lipoxygenase mRNA in hum...

journal_title：Biochemical and biophysical research communications

authors： Lakkis FG,Cruet EN,Nassar GM,Badr KF,Pascual DW

更新日期：1997-06-27 00:00:00

abstract：:The carboxyl-terminal domain of the zeta 1 subunit of the mouse NMDA receptor channel produced as a fusion protein with GST was phosphorylated in vitro by PKC. A mutant of the zeta 1 subunit without serine or threonine residues in the carboxyl-terminal domain (zeta 1-2-NST) was constructed and was expressed alone or t...

journal_title：Biochemical and biophysical research communications

authors： Yamakura T,Mori H,Shimoji K,Mishina M

更新日期：1993-11-15 00:00:00

abstract：:Extracellular matrix facilitates anchorage-dependent cell survival via interaction of its arginine-glycine-aspartate (RGD) motif with integrins. In this report, we describe an unexpected, apoptosis-promoting the effect of immobilized RGD (iRGD) on tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis. Mesangial ce...

journal_title：Biochemical and biophysical research communications

authors： Moreno-Manzano V,Lucio-Cazana J,Konta T,Nakayama K,Kitamura M

更新日期：2000-10-22 00:00:00

abstract：:Cellular prion protein (PrP(C)) is expressed not only in neuronal cells but also in non-neuronal cells such as astroglial cells. In the present study, the prion protein (PrP) gene (Prnp)-deficient astroglial cell line GpL1 from hippocampal cells of ZrchI Prnp(-/-) mice were established. Transfection of Prnp suppressed...

journal_title：Biochemical and biophysical research communications

authors： Nishimura T,Sakudo A,Xue G,Ikuta K,Yukawa M,Sugiura K,Onodera T

更新日期：2008-12-26 00:00:00

abstract：:Lysophosphatidylserine (LPS) was found to stimulate intracellular calcium increase in U87 human glioma cells. LPS also stimulated chemotactic migration of U87 human glioma cells, which was completely inhibited by pertussis toxin (PTX). Moreover, LPS was also found to stimulate ERK, p38 MAPK, JNK, and Akt activities in...

journal_title：Biochemical and biophysical research communications

authors： Lee SY,Lee HY,Kim SD,Jo SH,Shim JW,Lee HJ,Yun J,Bae YS

更新日期：2008-09-12 00:00:00

abstract：:Calcium is a key signaling molecule and ion involved in a variety of diverse processes in our central nervous system (CNS) which include gene expression, synaptic transmission and plasticity, neuronal excitability and cell maintenance. Proper control of calcium signaling is not only vital for neuronal physiology but a...

journal_title：Biochemical and biophysical research communications

authors： Mark MD,Schwitalla JC,Groemmke M,Herlitze S

更新日期：2017-02-19 00:00:00

abstract：:Incubation with protein kinase NII did not result in phosphorylation or inactivation of mouse kidney ornithine decarboxylase. Partially purified ornithine decarboxylase preparations contained a protein kinase activity and stimulated the activity of RNA polymerase I. However, these properties were due to contaminating ...

journal_title：Biochemical and biophysical research communications

authors： Seely JE,Stetler DA,Jacob ST,Pegg AE

更新日期：1984-04-16 00:00:00

abstract：:Myxothiazol is a respiratory chain complex III (CIII) inhibitor that binds to the ubiquinol oxidation site Qo of CIII. It blocks electron transfer from ubiquinol to cytochrome b and thus inhibits CIII activity. It has been utilized as a tool in studies of respiratory chain function in in vitro and cell culture models....

journal_title：Biochemical and biophysical research communications

authors： Davoudi M,Kallijärvi J,Marjavaara S,Kotarsky H,Hansson E,Levéen P,Fellman V

更新日期：2014-04-18 00:00:00

abstract：:In the present study, we demonstrated that there is a direct relationship between scratching behaviors induced by itch and functional changes in the brain reward system. Using a conditional place preference test, the rewarding effect was clearly evoked by scratching under both acute and chronic itch stimuli. The induc...

journal_title：Biochemical and biophysical research communications

authors： Setsu T,Hamada Y,Oikawa D,Mori T,Ishiuji Y,Sato D,Narita M,Miyazaki S,Furuta E,Suda Y,Sakai H,Ochiya T,Tezuka H,Iseki M,Inada E,Yamanaka A,Kuzumaki N,Narita M

更新日期：2021-01-01 00:00:00

abstract：:A study was undertaken to examine the effects of the tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, on pancreatic islet B cell differentiated function and number. Islets from 3-day-old rats were maintained in tissue culture for up to 30 days with or without the addition of the phorbol ester. Chan...

journal_title：Biochemical and biophysical research communications

authors： Schwizer RW

更新日期：1985-05-16 00:00:00

abstract：:Accurate chromosome segregation during cell division requires that sister chromatids are kept together by cohesin complex until anaphase, when the chromatids separate and distribute to the two daughter cells. Esco2 is an acetyltransferase that is required for the establishment of sister chromatid cohesion during S pha...

journal_title：Biochemical and biophysical research communications

authors： Kim BJ,Kang KM,Jung SY,Choi HK,Seo JH,Chae JH,Cho EJ,Youn HD,Qin J,Kim ST

更新日期：2008-07-25 00:00:00

abstract：:Specific receptors for murine TNF have been identified in homogenates of rodent brain. These receptors are saturable and bind TNF with sufficient affinity to ensure occupancy by cytokine elaborated during infection. 125I-mTNF was detected in four specific complexes of Mr 130,000, 90,000, 66,000 and 60,000 after affini...

journal_title：Biochemical and biophysical research communications

authors： Kinouchi K,Brown G,Pasternak G,Donner DB

更新日期：1991-12-31 00:00:00

abstract：:To improve the expression of the genes transduced by retroviral vectors, we have constructed a U3-based retroviral vector and evaluated its effect on the expression of an insert from the internal promoter. The unique feature of the vector is that the transduced gene is inserted at the U3 region of the 3' long terminal...

journal_title：Biochemical and biophysical research communications

authors： Chen BF,Hsieh CL,Chen DS,Hwang LH

更新日期：1992-04-15 00:00:00

abstract：:Cell extracts from wheat embryos have been widely used for mRNA-directed protein production. Here, we found that a significant fraction of exogenous linear RNAs are circularized in a wheat embryo extract. The circularization was seen only in uncapped RNAs. The amount of the circular species reached around 1% of the in...

journal_title：Biochemical and biophysical research communications

authors： Makino S,Sawasaki T,Tozawa Y,Endo Y,Takai K

更新日期：2006-09-08 00:00:00

abstract：:Bcl2-associated athoanogene (BAG) 3 is a member of the co-chaperone BAG family. It is induced by stressful stimuli such as heat shock and heavy metals, and it regulates cellular adaptive responses against stressful conditions. In this study, we identified a novel role for BAG3 in regulating the nuclear shuttling of HS...

journal_title：Biochemical and biophysical research communications

authors： Jin YH,Ahn SG,Kim SA

更新日期：2015-08-21 00:00:00

abstract：:This article has been withdrawn at the request of the author(s). The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Biochemical and biophysical research communications

authors： Shi C,Wu J,Fu M,Zhang B,Wang J,Yang X,Chi Y

更新日期：2014-05-10 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) is an inhibitor of the proliferation of bovine aortic endothelial cells in culture. Basal cell growth in serum-containing medium and cell proliferation stimulated by fibroblast growth factor (FGF) are inhibited by TGF-beta in a dose-dependent manner. Half-maximal inhibition o...

journal_title：Biochemical and biophysical research communications

authors： Fràter-Schröder M,Müller G,Birchmeier W,Böhlen P

更新日期：1986-05-29 00:00:00

abstract：:Biological membranes are composed of functionally relevant liquid-ordered and liquid-disordered domains that coexist. Within the liquid-ordered domains are low-density microdomains known as rafts with a unique lipid composition that is crucial for their structure and function. Lipid raft composition is altered in sphi...

journal_title：Biochemical and biophysical research communications

authors： Hattersley KJ,Hein LK,Fuller M

更新日期：2013-12-06 00:00:00

abstract：:The major biological effects of glucocorticoids are thought to be initiated through changes in the expression of cellular genes. However, the mechanisms involved in the suppression of some gene products by glucocorticoids are not well defined. ID13 mouse fibroblast cells were treated with the synthetic glucocorticoid ...

journal_title：Biochemical and biophysical research communications

authors： Wallace AD,Wheeler TT,Young DA

更新日期：1997-03-17 00:00:00

abstract：:Systemic injections of AAV vectors generally transduce to the liver more effectively than to cardiac and skeletal muscles. The short hairpin RNA (shRNA)-expressing AAV9 (shRNA-AAV9) can also reduce target gene expression in the liver, but not enough in cardiac or skeletal muscles. Higher doses of shRNA-AAV9 required f...

journal_title：Biochemical and biophysical research communications

authors： Mayra A,Tomimitsu H,Kubodera T,Kobayashi M,Piao W,Sunaga F,Hirai Y,Shimada T,Mizusawa H,Yokota T

更新日期：2011-02-11 00:00:00

abstract：:As in other vitamin D target cells, activation of voltage-dependent Ca2+ channels (VDCC) mediates the fast, non-genomic, 1,25(OH)2D3 stimulation of Ca2+ influx in skeletal muscle cells (SMC). 1,25(OH)2D3 has also been shown to rapidly induce the release of Ins(1,4,5)P3 in SMC. Experiments were performed to investigate...

journal_title：Biochemical and biophysical research communications

authors： Vazquez G,de Boland AR,Boland R

更新日期：1997-10-20 00:00:00

abstract：:A high concentration of immunoreactive neuropeptide Y was observed in rat platelets using a specific and sensitive radioimmunoassay for neuropeptide Y. Three kinds of high performance liquid chromatography combined with radioimmunoassay for neuropeptide Y showed that immunoreactive neuropeptide Y in rat platelets is i...

journal_title：Biochemical and biophysical research communications

authors： Ogawa T,Kitamura K,Kawamoto M,Eto T,Tanaka K

更新日期：1989-12-29 00:00:00

abstract：:Recognition of oligodeoxynucleotides containing CpG motifs (CpG-ODNs) by toll-like receptor 9 (TLR9) inhibits RANKL-induced osteoclastogenesis from precursors. This inhibitory effect suggests the possibility of using this strategy to block pathological bone loss. However, the enhancing effect of CpG-ODNs on OC formati...

journal_title：Biochemical and biophysical research communications

authors： Chang JH,Chang EJ,Kim HH,Kim SK

更新日期：2009-11-06 00:00:00

abstract：:Mutations in human BIGH3 (TGFB1), a gene identified after treatment of an adenocarcinoma cell line with TGF-beta, have been observed in patients with granular Groenouw type I, Reis-Bücklers, Thiel-Behnke, Avellino, and Lattice type I and IIIa, six autosomal dominant corneal dystrophies linked to chromosome 5q. In orde...

journal_title：Biochemical and biophysical research communications

authors： Schorderet DF,Menasche M,Morand S,Bonnel S,Büchillier V,Marchant D,Auderset K,Bonny C,Abitbol M,Munier FL

更新日期：2000-08-02 00:00:00

abstract：:A two fold stimulation in the incorporation of [3H-methyl] groups from [3H-methyl] methionine into phospholipids was seen in intact pancreatic islets within six minutes of exposure to a glucose concentration that stimulates insulin release. Nonstimulatory sugars, L-glucose and D-galactose, as well as dibutyryl cAMP, d...

journal_title：Biochemical and biophysical research communications

authors： Kowluru A,Rana RS,MacDonald MJ

更新日期：1984-07-31 00:00:00