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Galanin increases cytoplasmic calcium in insulin-producing RINm5F cells by activating phospholipase C.

Abstract：

:We showed previously that the neuropeptide, galanin, transiently and promptly increases the cytoplasmic concentration of Ca2+, [Ca2+]i, in insulin producing clonal RINm5F cells prior to a reduction in [Ca2+]i. We found that galanin (100 nM) transiently increased the [Ca2+]i in the presence of 15 mM glyceraldehyde and 3.3 mM glucose. This effect was abolished by both the inhibitor of the microsomal Ca2+ ATPase, thapsigargin, which depletes the intracellular Ca2+ stores, and the specific inhibitor of phospholipase C, U73122. In contrast, the blocker of L-type Ca2+ release, ryanodine, did not affect galanin-induced increase in [Ca2+]i. Thus, galanin induces a rapid mobilization of Ca2+ from intracellular Ca2+ stores in insulin producing RINm5F cells by an effect mediated by activated phospholipase C.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ahrén B

doi

10.1006/bbrc.1996.0550

subject

Has Abstract

pub_date

1996-04-05 00:00:00

pages

89-94

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(96)90550-1

journal_volume

221

pub_type

杂志文章

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