3-D Model of the bee venom acid phosphatase: insights into allergenicity.

abstract：:Hypoxia inducible factor-1 (HIF-1) is a transcription factor composed of two subunits, HIF-1alpha and ARNT, which is activated under hypoxia. HIF-1alpha mRNA is expressed constitutively in a wide variety of cell types, whereas in some others HIF1A gene expression is upregulated by hypoxia. In this report, we show that...

journal_title：Biochemical and biophysical research communications

authors： Minet E,Ernest I,Michel G,Roland I,Remacle J,Raes M,Michiels C

更新日期：1999-08-02 00:00:00

abstract：:Invadopodia are cellular structures that are thought to mediate tumor invasion. ASAP1, an Arf GTPase-activating protein (GAP) containing a BAR domain, is a substrate of Src. ASAP1 is required for the assembly of invadopodia and podosomes, which are Src-induced structures related to invadopodia in NIH 3T3 fibroblasts. ...

journal_title：Biochemical and biophysical research communications

authors： Shiba Y,Randazzo PA

更新日期：2011-03-25 00:00:00

abstract：:Neurotensin (NT) is now classified as a brain-gut peptide in the central nervous system and gastrointestinal tract. In the present study, we characterized the NT receptors on the rat liver plasma membranes. The specific binding of [3H]NT was time dependent, reversible, and saturable. Scatchard analysis of the specific...

journal_title：Biochemical and biophysical research communications

authors： Muraki K,Nishi Y,Arai M,Kubo N,Ueda K,Shikata H,Nakata Y,Segawa T,Yanaihara N,Yajima H

更新日期：1987-06-30 00:00:00

abstract：:The influence of collagen as an effective substitute for gelatin was investigated on properties of chitosan/gelatin hydrogels for fibroblasts growth and attachment for wound dressing applications. We synthesized hydrogels based on chitosan associated with collagen and gelatin biopolymers (in the ratio of 1:5 and 1:1, ...

journal_title：Biochemical and biophysical research communications

authors： Mousavi S,Khoshfetrat AB,Khatami N,Ahmadian M,Rahbarghazi R

更新日期：2019-10-22 00:00:00

abstract：:The previous study showed involvement of spinal glia in tetanically sciatic stimulation-induced long-term potentiation (LTP) of C-fiber-evoked field potentials in the spinal dorsal horn. In the present study, the electrophysiological recording and paw withdrawal threshold (PWT) to von Frey stimulation were assessed fo...

journal_title：Biochemical and biophysical research communications

authors： Ying B,Lü N,Zhang YQ,Zhao ZQ

更新日期：2006-02-24 00:00:00

abstract：:We have developed a solid matrix immunoassay to determine the binding of interleukin-2 (IL-2) to specific gangliosides. The assay establishes that recombinant human IL-2 binds to ganglioside GD(1b) but not to any other gangliosides (GM(1), GM(2), GM(3), GD(1a), GD(2), GD(3), and GT(1b)). The binding varies with the ra...

journal_title：Biochemical and biophysical research communications

authors： Ravindranath MH,Gonzales A,Soh D,Nishimoto K,Tam WY,Bilchik A,Morton DL,O'Day S

更新日期：2001-05-04 00:00:00

abstract：:The root-knot nematode (RKN) Meloidogyne incognita reproduces on the roots of tobacco (Nicotiana tabacum), damaging crops, reducing crop yield, and causing economic losses annually. The development of resistant genotypes is an alternative strategy to effectively control these losses. However, the molecular mechanism r...

journal_title：Biochemical and biophysical research communications

authors： Xing X,Li X,Zhang M,Wang Y,Liu B,Xi Q,Zhao K,Wu Y,Yang T

更新日期：2017-01-22 00:00:00

abstract：:The NS3 serine protase of Hepatitis C virus (HCV) requires NS4A protein as a cofactor for efficient cleavage at four sites in the nonstructural region. The cofactor activity has been mapped to the central hydrophobic region (aa 22-34) of this 54-amino-acid NS4A protein, and site-directed mutagenesis has identified alt...

journal_title：Biochemical and biophysical research communications

authors： Butkiewicz NJ,Yao N,Wright-Minogue J,Zhang R,Ramanathan L,Lau JY,Hong Z,Dasmahapatra B

更新日期：2000-01-07 00:00:00

abstract：:We found that high galectin-1 (Gal-1) mRNA levels were associated with invasive squamous cell carcinoma (SCC) cells that expressed Snail, an epithelial-to-mesenchymal transition (EMT) regulator. Both Gal-1 overexpression and soluble Gal-1 treatment accelerated invasion and collective cell migration, along with activat...

journal_title：Biochemical and biophysical research communications

authors： Rizqiawan A,Tobiume K,Okui G,Yamamoto K,Shigeishi H,Ono S,Shimasue H,Takechi M,Higashikawa K,Kamata N

更新日期：2013-11-29 00:00:00

abstract：:Rab7, a member of the Rab family small G proteins, is involved in the late stage of the endocytic pathway. We previously identified a Rab7 target protein, Rabring7, which contains a RING finger domain at its C termini, but the precise role of Rabring7 remains unknown. In this study, we demonstrate using an in vitro ub...

journal_title：Biochemical and biophysical research communications

authors： Sakane A,Hatakeyama S,Sasaki T

更新日期：2007-06-15 00:00:00

abstract：:Lipopolysaccharides (LPS) of Porphyromonas gingivalis have been implicated in the initiation and development of periodontal diseases. In a previous study, we investigated the signal transduction pathway of P. gingivalis and demonstrated that LPS stimulates the production of interleukin (IL)-6 in human gingival fibrobl...

journal_title：Biochemical and biophysical research communications

authors： Wang PL,Shirasu S,Shinohar M,Azuma Y,Daito M,Yasuda H,Ohura K

更新日期：1999-09-24 00:00:00

abstract：:Endothelin-1 acts as a potent autocrine and paracrine mediator in the kidney. Glomeruli and renal arterioles also express functional thrombin receptors which mediate the cellular effects of thrombin. Using the binding on glomerular epithelial cells of 125I-labeled ATAP2, a monoclonal antibody raised against the functi...

journal_title：Biochemical and biophysical research communications

authors： Chen X,Berrou J,Nguyen G,Sraer JD,Rondeau E

更新日期：1995-12-14 00:00:00

abstract：:Proteins with expanded polyglutamine domains cause eight inherited neurodegenerative diseases including Huntington's disease. In a previous paper, we identified peptides that inhibit polyglutamine protein aggregation and cell death and now describe the amino acid sequence requirements necessary for these activities. T...

journal_title：Biochemical and biophysical research communications

authors： Ren H,Nagai Y,Tucker T,Strittmatter WJ,Burke JR

更新日期：2001-11-02 00:00:00

abstract：:Using a highly sensitive RT-PCR technique that measures mRNA (cDNA)-to-DNA ratios, we are able to detect constitutive CYP1A1 mRNA in adult mouse liver as well as in the oocyte. Twelve hours after fertilization of the ovum, there is a more than 100-fold increase in constitutive CYP1A1 mRNA levels; this dramatic increas...

journal_title：Biochemical and biophysical research communications

authors： Dey A,Nebert DW

更新日期：1998-10-20 00:00:00

abstract：:Retinyl ester concentration is regulated by retinoic acid (RA) through an autoregulatory loop, which acts on lecithin:retinol acyltransferase (LRAT). We tested whether retinol esterification activity is downregulated in human mammary carcinoma cells and whether LRAT expression is RAR-regulated. Normal human mammary ep...

journal_title：Biochemical and biophysical research communications

authors： Andreola F,Giandomenico V,Spero R,De Luca LM

更新日期：2000-12-29 00:00:00

abstract：:Strengthening of cell-matrix adhesions in response to applied force has been well documented. However, while implied by various lines of evidence, the force-mediated strengthening of cell-cell adhesions has not been directly demonstrated. In the current study, we present results consistent with force strengthening in ...

journal_title：Biochemical and biophysical research communications

authors： Kris AS,Kamm RD,Sieminski AL

更新日期：2008-10-10 00:00:00

abstract：:A tryptic peptide of bovine beta-casein (amino acid residues 184-202) was used as a model antigen to investigate how the relative position of the (helper) T cell and B cell determinants on a protein antigen influences the antibody response. Immunization with the peptide elicited a considerably higher anti-peptide resp...

journal_title：Biochemical and biophysical research communications

authors： Hachimura S,Enomoto A,Kaminogawa S

更新日期：1990-06-15 00:00:00

abstract：:Treatment of the rat C6 glioma cell line with interleukin-1 beta (IL-1 beta) resulted in an accumulation of cytosolic phospholipase A2 (cPLA2) in mRNA level. The increase of cPLA2 in mRNA level was observed at 6 hours after treatment of IL-1 beta and reached to the maximal level at 12 hours. The accumulation also rema...

journal_title：Biochemical and biophysical research communications

authors： Ozaki M,Morii H,Qvist R,Watanabe Y

更新日期：1994-11-30 00:00:00

abstract：:It is well established that lipid metabolism is controlled, in part, by circadian clocks. However, circadian clocks lose temporal precision with age and correlates with elevated incidence in dyslipidemia and metabolic syndrome in older adults. Because our lab has shown that lipoic acid (LA) improves lipid homeostasis ...

journal_title：Biochemical and biophysical research communications

authors： Keith D,Finlay L,Butler J,Gómez L,Smith E,Moreau R,Hagen T

更新日期：2014-07-18 00:00:00

abstract：:Exosomes or microvesicles that are secreted from cells are considered to play important roles in tumor microenvironment. Carbonic anhydrase 9 (CA9), which is induced by hypoxia-inducible factor 1 (HIF1) in response to hypoxia, is overexpressed in many types of cancer including renal cell carcinoma (RCC). We examined t...

journal_title：Biochemical and biophysical research communications

authors： Horie K,Kawakami K,Fujita Y,Sugaya M,Kameyama K,Mizutani K,Deguchi T,Ito M

更新日期：2017-10-21 00:00:00

abstract：:Peptide biosynthesis within a neuron involves several steps occurring at the soma and during its travel to the nerve terminal, where it accumulates to be released under stimulatory conditions. We have measured hypothalamic TRH and TRH mRNA during ontogeny and circadian cycle and observed that TRH mRNA variations are m...

journal_title：Biochemical and biophysical research communications

authors： Covarrubias L,Uribe RM,Méndez M,Charli JL,Joseph-Bravo P

更新日期：1988-02-29 00:00:00

abstract：:GTP cyclohydrolase I is the rate-limiting enzyme in the de novo synthesis pathway of tetrahydrobiopterin which is an essential cofactor for all NO synthase isoforms. The expression of GTP cyclohydrolase I is regulated on a transcriptional level by a variety of cytokines like interleukin 1beta or tumor necrosis factor ...

journal_title：Biochemical and biophysical research communications

authors： Lapize C,Plüss C,Werner ER,Huwiler A,Pfeilschifter J

更新日期：1998-10-29 00:00:00

abstract：:Oxidized low-density lipoproteins (LDL) accumulate in the vascular wall and promote a local inflammatory process contributing to the progression of atheromatous plaque. The key role of myeloperoxidase (MPO) in this process has been documented and the enzyme has been involved in the oxidative modification of apolipopro...

journal_title：Biochemical and biophysical research communications

authors： Van Antwerpen P,Boudjeltia KZ,Babar S,Legssyer I,Moreau P,Moguilevsky N,Vanhaeverbeek M,Ducobu J,Nève J

更新日期：2005-11-11 00:00:00

abstract：:A folded synthetic peptide analog of NDF (NDF5), which has the 52 amino acid EGF-like domain of NDF alpha 2, has been characterized. The folded peptide stimulates tyrosine phosphorylation of Her2, Her3 and Her4 in breast cancer cells and competes with low affinity with full-length NDF alpha 2 for binding to the cells,...

journal_title：Biochemical and biophysical research communications

authors： Kita Y,Mayer J,Zamborelli T,Hara S,Rohde M,Watson E,Koski R,Ratzkin B,Nicolson M

更新日期：1995-05-16 00:00:00

abstract：:Serine proteinase inhibitors are widely distributed in nature and inhibit the activity of enzymes like trypsin and chymotrypsin. These proteins interfere with the physiological processes such as germination, maturation and form the first line of defense against the attack of seed predator. The most thoroughly examined...

journal_title：Biochemical and biophysical research communications

authors： Sattar R,Ali SA,Kamal M,Khan AA,Abbasi A

更新日期：2004-02-13 00:00:00

abstract：:A specific radioimmunoassay was developed for metorphamide, an endogenous, amidated opioid octapeptide, originally isolated from bovine brain and human pheochromocytoma tissues. The radioimmunoassay was used to determine the concentration of immunoreactive metorphamide in extracts from dissected regions of rat and gui...

journal_title：Biochemical and biophysical research communications

authors： Sonders M,Barchas JD,Weber E

更新日期：1984-08-16 00:00:00

abstract：:Most in vivo studies on the conversion to insulin-producing cells with AAV carrying PDX1 gene are performed in rodents. However, there is little information regarding Adeno-associated virus (AAV) carrying PDX1 gene transduced to human liver in vivo because accidental death caused by unpredicted factors cannot be denie...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto H,Mizushima T,Ogura T,Kagawa T,Tomiyama K,Takahashi R,Yagoto M,Kawai K,Chijiwa T,Nakamura M,Suemizu H

更新日期：2016-09-23 00:00:00

abstract：:Polyclonal antibodies have been obtained against a synthetic dodecapeptide identical to the aminoacid sequence 120-131 DSPIKDGVWPPE (inferred from its DNA sequence) of Paracoccus denitrificans cytochrome c oxidase subunit III. The antibodies had a titer higher than 1:10000 when tested against the antigen. These antibo...

journal_title：Biochemical and biophysical research communications

authors： Müller M,Labonia N,Azzi A

更新日期：1988-08-15 00:00:00

abstract：:In order to study the role of phosphatidylinositol-3-kinase (PI3K) in insulin action, we employed a specific inhibitor of PI3K, LY294002, and measured five biological functions of insulin in mouse 3T3 fibroblasts overexpressing human insulin receptors. LY294002 had no effect on tyrosine phosphorylation of both the ins...

journal_title：Biochemical and biophysical research communications

authors： Sanchez-Margálet V,Goldfine ID,Vlahos CJ,Sung CK

更新日期：1994-10-28 00:00:00

abstract：:NF-kappaB is a pleiotropic transcription factor, which regulates osteoclast formation, function, and survival. The finding that the deletion of both NF-kappaB p50 and p52 subunits resulted in osteopetrosis due to the absence of osteoclasts was followed by the observation that NF-kappaB is essential for RANK-expressing...

journal_title：Biochemical and biophysical research communications

authors： Soysa NS,Alles N

更新日期：2009-01-02 00:00:00