NF-kappaB functions in osteoclasts.

Abstract:

:NF-kappaB is a pleiotropic transcription factor, which regulates osteoclast formation, function, and survival. The finding that the deletion of both NF-kappaB p50 and p52 subunits resulted in osteopetrosis due to the absence of osteoclasts was followed by the observation that NF-kappaB is essential for RANK-expressing osteoclast precursors to differentiate into TRAP+ osteoclasts in response to RANKL and other osteoclastogenic cytokines. Thus, inhibitors of NF-kappaB should prevent osteoclast formation induced directly or indirectly by RANKL or TNF. In this mini review, we discuss the research findings that revealed essential roles of NF-kappaB signaling in osteoclasts.

authors

Soysa NS,Alles N

doi

10.1016/j.bbrc.2008.10.146

subject

Has Abstract

pub_date

2009-01-02 00:00:00

pages

1-5

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)02116-5

journal_volume

378

pub_type

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