MicroRNA-376c suppresses non-small-cell lung cancer cell growth and invasion by targeting LRH-1-mediated Wnt signaling pathway.

abstract：:We studied about the physicochemical stability of a novel heparin-binding growth/differentiation factor, midkine (MK). It was found that synthetic human MK was heat and acid stable. Neither incubation at 80 degrees C for 90 sec nor treatment at low pH affected the elution profile of MK molecule on the high performance...

journal_title：Biochemical and biophysical research communications

authors： Kojima S,Inui T,Muramatsu H,Kimura T,Sakakibara S,Muramatsu T

更新日期：1995-11-13 00:00:00

abstract：:Tumor necrosis factor (TNF) contributes to insulin resistance by binding to the 55kDa TNF receptor (TNF-R55), resulting in serine phosphorylation of proteins such as insulin receptor (IR) substrate (IRS)-1, followed by reduced tyrosine phosphorylation of IRS-1 through the IR and, thereby, diminished IR signal transduc...

journal_title：Biochemical and biophysical research communications

authors： Csehi SB,Mathieu S,Seifert U,Lange A,Zweyer M,Wernig A,Adam D

更新日期：2005-04-01 00:00:00

abstract：:The Sir proteins, namely Sir2, 3 and 4, have roles related to heterochromatin, but genome-wide studies have revealed their presence at many euchromatic loci, although the functional meaning of this is still not clear. Nhp6a is an abundant HMG-like protein in yeast, which has a role in transcription by modulating chrom...

journal_title：Biochemical and biophysical research communications

authors： Ciuffetta A,Salerno D,Camilloni G,Venditti S

更新日期：2015-05-22 00:00:00

abstract：:PmrA/PmrB and PhoP/PhoQ are a pair of two-component systems (TCSs) that allow the Gram-negative bacteria to survive the cationic antimicrobial peptide polymyxin B. The two TCSs are linked by the polymyxin resistance protein, PmrD. The PhoP-activated PmrD protects the phosphorylated response regulator PmrA from dephosp...

journal_title：Biochemical and biophysical research communications

authors： Fu W,Yang F,Kang X,Zhang X,Li Y,Xia B,Jin C

更新日期：2007-10-05 00:00:00

abstract：:Primary aldosteronism is an important, potentially curable, form of hypertension. We examined the possible association between restriction fragment length polymorphisms in the atrial natriuretic peptide (ANP) gene and responsiveness of aldosterone to angiotensin II in 59 patients with primary aldosteronism due to aldo...

journal_title：Biochemical and biophysical research communications

authors： Tunny TJ,Jonsson JR,Klemm SA,Ballantine DM,Stowasser M,Gordon RD

更新日期：1994-11-15 00:00:00

abstract：:Extracellular superoxide dismutase (EC-SOD) is the major isozyme of SOD in arteries, but is also abundant in lungs. In particular, mouse lungs contain large amounts of EC-SOD compared to lungs in other mammals. This suggests that EC-SOD may have an amplified function in the mouse lung. This study describes the purific...

journal_title：Biochemical and biophysical research communications

authors： Fattman CL,Enghild JJ,Crapo JD,Schaefer LM,Valnickova Z,Oury TD

更新日期：2000-08-28 00:00:00

abstract：:Thyroglobulin of very low iodine content has been prepared from a single non-toxic human goitre. The initial iodine content of the protein (0.038%) has been increased to levels of 0.16% and 0.85% by in vitro treatment with thyroid peroxidase and the resulting proteins studied with respect to their intrinsic fluorescen...

journal_title：Biochemical and biophysical research communications

authors： Zabel KM,Rawitch AB

更新日期：1984-05-31 00:00:00

abstract：:Recently, we have shown that the thyrotropin (TSH) binding regions of human thyrotropin receptor (TSHR) reside in two areas within residues 12-44 and 308-344. Serial antisera were raised against four overlapping synthetic peptides representing these two regions of TSHR (peptides 12-30, 24-44, 308-328, and 324-344) and...

journal_title：Biochemical and biophysical research communications

authors： Sakata S,Ogawa T,Matsui I,Manshouri T,Atassi MZ

更新日期：1992-02-14 00:00:00

abstract：:5-Lipoxygenase is the key enzyme in the biosynthesis of leukotrienes, powerful lipid mediators involved in inflammation, cell-cell communication, and other important physiological and pathological conditions. Particularly, cysteinyl-leukotrienes have been recognized as playing a significant role in the pathophysiology...

journal_title：Biochemical and biophysical research communications

authors： Ramires R,Caiaffa MF,Tursi A,Haeggström JZ,Macchia L

更新日期：2004-11-12 00:00:00

abstract：:The nuclear enzyme poly(ADP-ribosyl) transferase (pADPRT) catalyzes the formation of poly(ADP-ribose) from NAD+. Several nuclear proteins and pADPRT itself are targets for the modification by poly(ADP-ribosyl)ation. It is demonstrated here that poly(ADP-ribose) or pADPRT automodified with poly(ADP-ribose) interacts no...

journal_title：Biochemical and biophysical research communications

authors： Mayer-Kuckuk P,Ullrich O,Ziegler M,Grune T,Schweiger M

更新日期：1999-06-16 00:00:00

abstract：:Our laboratory demonstrated that endoplasmic reticulum iPLA2 (ER-iPLA2) activity protects renal cells from oxidant-induced cell death and lipid peroxidation. The goals of this study were to determine the PLA2 isoform(s) responsible for ER-iPLA2 activity in different species and tissues. ER-iPLA2 activity was observed ...

journal_title：Biochemical and biophysical research communications

authors： Kinsey GR,Cummings BS,Beckett CS,Saavedra G,Zhang W,McHowat J,Schnellmann RG

更新日期：2005-02-04 00:00:00

abstract：:Platelet activating factor has been found to increase the intracellular level of free calcium (as monitored by the fluorescent calcium indicator quin-2) and to stimulate the turnover of the polyphosphoinositides in rabbit neutrophils. Calcium mobilization induced by platelet activating factor, in contrast to previous ...

journal_title：Biochemical and biophysical research communications

authors： Naccache PH,Molski MM,Volpi M,Becker EL,Sha'afi RI

更新日期：1985-07-31 00:00:00

abstract：:The main transport mechanism of reabsorption of sodium bicarbonate and fluid in the renal proximal tubules involves Na(+)/H(+) exchanger 3 (NHE3), which is acutely and chronically downregulated by parathyroid hormone (PTH). Although PTH is known to exert an inhibitory effect on NHE3 expression and transcription, the m...

journal_title：Biochemical and biophysical research communications

authors： Neri EA,Bezerra CN,Queiroz-Leite GD,Polidoro JZ,Rebouças NA

更新日期：2015-06-12 00:00:00

abstract：:A dye displacement method was developed for determination of the affinities of compounds toward the active site of the detergent-solubilized sarcoplasmic reticulum CaATPase. Titration of the enzyme with 2',3'-O-(2,4,6-trinitrophenyl)-ADP resulted in a large absorbance difference in the visible spectrum. Subsequent add...

journal_title：Biochemical and biophysical research communications

authors： Coll RJ,Murphy AJ

更新日期：1986-07-31 00:00:00

abstract：:Imatinib mesylate, commercially known as Gleevec/Glivec, is the first targeted anticancer drug that inhibits activity of the tyrosine kinases, c-ABL, c-KIT, and PDGFR. A number of studies have shown that treatment with imatinib mesylate elicits extracellular signal-related kinase (ERK) activation, which, in turn, has ...

journal_title：Biochemical and biophysical research communications

authors： Lee J,Ko J,Kim HJ,Im H,Kim EJ,Yi JY

更新日期：2018-12-02 00:00:00

abstract：:Erythroid band 4.1 enhances the binding of erythroid spectrin to phosphatidylserine vesicles under conditions of ionic strength and at protein concentrations similar to those in the red cell. The extent of enhancement depends on the concentration of band 4.1; at 2 microM 4.1, spectrin binding increases approximately 1...

journal_title：Biochemical and biophysical research communications

authors： Takeshita K,MacDonald RI,MacDonald RC

更新日期：1993-02-26 00:00:00

abstract：:Ambroxol is often used as a mucolytic agent in various lung diseases. However, it is unclear how ambroxol acts on bronchial epithelial cells. To clarify the action of ambroxol, we studied the effects of ambroxol on the ion transport in human Calu-3 cells, a human submucosal serous cell line, measuring the transepithel...

journal_title：Biochemical and biophysical research communications

authors： Hasegawa I,Niisato N,Iwasaki Y,Marunaka Y

更新日期：2006-05-05 00:00:00

abstract：:Carp acclimated to 10 degrees C gave 69k, 66k, and 62kDa light meromyosin (LMM) fragments in SDS-PAGE, while fish acclimated to 30 degrees C gave 74k, 69k, 66k, and 62kDa fragments. The microsequence analysis revealed that the 69k and 66kDa components from the 10 degrees C-acclimated carp contained an N-terminal amino...

journal_title：Biochemical and biophysical research communications

authors： Watabe S,Imai J,Nakaya M,Hirayama Y,Okamoto Y,Masaki H,Uozumi T,Hirono I,Aoki T

更新日期：1995-03-08 00:00:00

abstract：:The hydrolysis of sphingomyelin in cells derived from a Niemann-Pick patient was studied using both a labelled precursor and measurement of endogenous levels. In vitro exposure of the cells to cannabidiol resulted in a large decrease in both the relative and absolute amounts of this lipid; the drug had a smaller effec...

journal_title：Biochemical and biophysical research communications

authors： Burstein S,Hunter SA,Renzulli L

更新日期：1984-05-31 00:00:00

abstract：:We established a simple and highly efficient method for in vivo gene transfer using HVJ (Sendai virus) and liposomes. Plasmid DNA and high mobility group 1 (HMG1) protein were co-encapsulated in liposomes by agitation and sonication and were co-introduced into cells by HVJ-mediated membrane fusion. pACT SVT DNA, as a ...

journal_title：Biochemical and biophysical research communications

authors： Tomita N,Higaki J,Morishita R,Kato K,Mikami H,Kaneda Y,Ogihara T

更新日期：1992-07-15 00:00:00

abstract：:It is widely considered that it is not appropriate to treat beta-pairs in isolation, since other secondary structural models (such as helices, coils), protein topology and protein tertiary structures would limit beta-strand pairing. However, to understand the underlying mechanisms of beta-sheet formation, studies ough...

journal_title：Biochemical and biophysical research communications

authors： Zhang N,Ruan J,Duan G,Gao S,Zhang T

更新日期：2009-08-28 00:00:00

abstract：:Renal dopamine receptors have been shown to play a critical role in ROS-dependent hypertension. D5 dopamine receptor deficient (D5-/-) mice are hypertensive and have increased systemic oxidative stress which is manifested in the kidney and the brain. To further investigate the underlying mechanisms of hypertension in ...

journal_title：Biochemical and biophysical research communications

authors： Stoelting M,Geyer M,Reuter S,Reichelt R,Bek MJ,Pavenstädt H

更新日期：2009-01-30 00:00:00

abstract：:Recombinant scorpion anti-excitation peptide (rANEP) has previously been expressed using the pET32a system and purified via affinity chromatography. However, rANEP is expressed in BL21(DE3) cells as an inclusion body, and the affinity tag can not be removed. To overcome this problem, we used a variety of protein, DsbA...

journal_title：Biochemical and biophysical research communications

authors： Han T,Ming H,Deng L,Zhu H,Liu Z,Zhang J,Song Y

更新日期：2017-01-01 00:00:00

abstract：:During biosynthetic studies on bialaphos to reveal the formation mechanisms of carbon-phosphorous bonds in detail, three new metabolites containing a H-P-C bond structure were isolated from the fermentation broth of a mutant of Streptomyces hygroscopicus SF-1293. Based on the spectroscopic analysis, the structures of ...

journal_title：Biochemical and biophysical research communications

authors： Seto H,Imai S,Tsuruoka T,Ogawa H,Satoh A,Sasaki T,Otake N

更新日期：1983-03-29 00:00:00

abstract：:With the emergence of electrospray ionization mass spectrometry (ESI-MS), mass spectrometry is no longer restricted to the study of small, stable molecules, but has become a viable technique to study large biomolecules as well as noncovalent biomolecular complexes. ESI-MS has been used to study noncovalent interaction...

journal_title：Biochemical and biophysical research communications

authors： Veenstra TD

更新日期：1999-04-02 00:00:00

abstract：:Male Djungarian hamsters (Phodopus sungorus; 45 animals per group) were either sham-exposed or exposed to a sinusoidal magnetic field for 56 days (Experiment 1: 50 Hz, 450 microTesla peak; max. dB/dt = 140 mTesla s(-1); 24 hrs day(-1)). Except for day 7, no effects were observed with respect to body weights during exp...

journal_title：Biochemical and biophysical research communications

authors： Niehaus M,Brüggemeyer H,Behre HM,Lerchl A

更新日期：1997-05-29 00:00:00

abstract：:A novel membrane-soluble prodrug of the 5'-monophosphate derivative of 3TC containing a phenyl group and the methyl ester of L-alanine linked to the phosphorus through a phosphoramidate bond with the primary amino moiety (designated Cf 1109) was prepared. The 3TC prodrug proved less potent an inhibitor of HIV-1 and HI...

journal_title：Biochemical and biophysical research communications

authors： Balzarini J,Wedgwood O,Kruining J,Pelemans H,Heijtink R,De Clercq E,McGuigan C

更新日期：1996-08-14 00:00:00

abstract：:To date, tick-borne flaviviruses responsible for hemorrhagic fever in humans have been isolated in Siberia (Omsk hemorrhagic fever virus), India (Kyasanur Forest disease virus, KFDV), and in Saudi Arabia (Alkhurma virus, ALKV). Prior to this study, only partial coding sequences of these severe pathogens had been deter...

journal_title：Biochemical and biophysical research communications

authors： Charrel RN,Zaki AM,Attoui H,Fakeeh M,Billoir F,Yousef AI,de Chesse R,De Micco P,Gould EA,de Lamballerie X

更新日期：2001-09-21 00:00:00

abstract：:The action of brain peptidases on NH2-terminal sequences of adrenocorticotropin was studied by incubation of ACTH-(1-16)-NH2 under different pH conditions. Profiles of metabolites and time course of product formation were obtained by HPLC analysis of the digests. Fragments of ACTH-(1-16)-NH2 were isolated and characte...

journal_title：Biochemical and biophysical research communications

authors： Wang XC,Burbach JP,Verhoef JC

更新日期：1983-02-28 00:00:00

abstract：:Contraction of rat uterine smooth muscle related to phosphorylation state of myosin light chain under various conditions was investigated. In the Ca2(+)-containing medium, both high K+ and oxytocin induced marked contraction of the muscle accompanied by pronounced phosphorylation of myosin light chain. In the Ca2(+)-f...

journal_title：Biochemical and biophysical research communications

authors： Oishi K,Takano-Ohmuro H,Minakawa-Matsuo N,Suga O,Karibe H,Kohama K,Uchida MK

更新日期：1991-04-15 00:00:00