Establishment of the ELISA for murine soluble gp130, a signal transducer for the IL-6 family cytokine, and its detection in the ascitic fluids of tumor-bearing mice.

abstract：:Dasatinib, a second-generation tyrosine kinase inhibitor, is indicated for the therapy of imatinib-resistant leukemia and also for the treatment of solid cancers. Here, we report a novel effect of dasatinib of inducing differentiation in normal human melanocytes. Treatment with dasatinib significantly increased the me...

journal_title：Biochemical and biophysical research communications

authors： Kang B,Kim Y,Park TJ,Kang HY

更新日期：2020-03-19 00:00:00

abstract：:The effect of aging and treatment with acetyl-L-carnitine on the lipid composition of rat plasma and erythrocytes was studied. It was found that aging increases the levels of free and esterified cholesterol. Fatty acid patterns in the plasma of aged rats show remarkable alterations when compared with control rats. The...

journal_title：Biochemical and biophysical research communications

authors： Ruggiero FM,Cafagna F,Gadaleta MN,Quagliariello E

更新日期：1990-07-31 00:00:00

abstract：:Coordinated migration of endothelial cells models the remodeling of existing endothelia as well as angiogenesis and vasculogenesis. Platelet-endothelial cell adhesion molecule-1, PECAM-1, a transmembrane endothelial adhesion protein, binds and activates the tyrosine phosphatase SHP-2 via phosphotyrosines 663 and 686. ...

journal_title：Biochemical and biophysical research communications

authors： Gratzinger D,Barreuther M,Madri JA

更新日期：2003-01-31 00:00:00

abstract：:We have used electron paramagnetic resonance (EPR) to examine the structural impact of oxidizing specific methionine (M) side chains in calmodulin (CaM). It has been shown that oxidation of either M109 or M124 in CaM diminishes CaM regulation of the muscle calcium release channel, the ryanodine receptor (RyR), and tha...

journal_title：Biochemical and biophysical research communications

authors： McCarthy MR,Thompson AR,Nitu F,Moen RJ,Olenek MJ,Klein JC,Thomas DD

更新日期：2015-01-09 00:00:00

abstract：:Genetic predisposition is necessary for polycystic kidney disease (PKD) initiation, although there are other, incompletely identified downstream processes that are required for cyst growth. Their characterization may provide a unique opportunity for clinical interventions. One of the poorly studied phenomena in PKD is...

journal_title：Biochemical and biophysical research communications

authors： Arkhipov SN,Pavlov TS

更新日期：2019-05-21 00:00:00

abstract：:Most G protein-coupled receptors (GPCRs) are N-glycosylated proteins but the role of this post-translational modification in GPCR biosynthesis has not been extensively studied. We previously showed that the non-glycosylated AT(1) receptor is inefficiently expressed at the cell surface. In this study, we addressed whet...

journal_title：Biochemical and biophysical research communications

authors： Lanctôt PM,Leclerc PC,Escher E,Guillemette G,Leduc R

更新日期：2006-02-10 00:00:00

abstract：BACKGROUND:The prognosis of patients after acute kidney injury (AKI) is poor and treatment is limited. AKI is mainly caused by renal ischemia/reperfusion injury (IRI). During the extension phase of IRI, endothelial damage may participate in ischemia and inflammation. Endothelin-1 (ET-1) which is mostly secreted by endo...

journal_title：Biochemical and biophysical research communications

authors： Arfian N,Emoto N,Vignon-Zellweger N,Nakayama K,Yagi K,Hirata K

更新日期：2012-08-24 00:00:00

abstract：:53BP1 plays important roles in checkpoint signaling and repair for DNA double-strand breaks. We found that a colon cancer cell line, SW48, expressed a splicing variant form of 53BP1, which lacks the residues corresponding to exons 10 and 11. Activation of ATM and phosphorylation of ATM and ATR targets occurred in SW48...

journal_title：Biochemical and biophysical research communications

authors： Iwabuchi K,Matsui T,Hashimoto M,Matsumoto Y,Kurihara T,Date T

更新日期：2008-11-21 00:00:00

abstract：:Promyelocytic leukaemia (PML) is a tumor suppressor protein covalently conjugated with SUMO family proteins, leading to the formation of PML nuclear bodies (NBs). PML-NBs provide a platform for efficient posttranslational modification of targets and protein-protein interaction, contributing to the adjustment of gene e...

journal_title：Biochemical and biophysical research communications

authors： Fukuda T,Kigoshi-Tansho Y,Naganuma T,Kazaana A,Okajima T,Tsuruta F,Chiba T

更新日期：2017-01-22 00:00:00

abstract：:Junctional membrane complexes (JMCs) generated by junctophilins are required for Ca(2+)-mediated communication between cell-surface and intracellular channels in excitable cells. Knockout mice lacking neural junctophilins (JP-DKO) show severe motor defects and irregular cerebellar plasticity due to abolished channel c...

journal_title：Biochemical and biophysical research communications

authors： Ikeda A,Miyazaki T,Kakizawa S,Okuno Y,Tsuchiya S,Myomoto A,Saito SY,Yamamoto T,Yamazaki T,Iino M,Tsujimoto G,Watanabe M,Takeshima H

更新日期：2007-11-23 00:00:00

abstract：:Papiliocin is a 37-residue peptide isolated from the swallowtail butterfly Papilio xuthus. In this study, we found that Papiliocin induced the accumulation of reactive oxygen species (ROS) and hydroxyl radicals known to be important regulators of apoptosis in Candida albicans. To examine the relationship between the a...

journal_title：Biochemical and biophysical research communications

authors： Hwang B,Hwang JS,Lee J,Kim JK,Kim SR,Kim Y,Lee DG

更新日期：2011-04-29 00:00:00

abstract：:Comparative fluorimetric, flow cytofluorimetric and fluorescence ratiometric determinations of intracellular K+ concentrations in murine haemopoietic cells (FDCP-Mix clone A4) cultured in the presence and absence of the specific growth factor Interleukin-3 were carried out with the fluorescent potassium-binding benzof...

journal_title：Biochemical and biophysical research communications

authors： Laskay G,Várhelyi T,Dale RE,Dexter TM

更新日期：1995-09-14 00:00:00

abstract：:Five different receptor subtypes for neuropeptide Y (NPY) have recently been cloned in mammals. We have discovered three distinct subtypes by PCR in the zebrafish, Danio rerio, and describe here one of these called zYc. The protein sequence identity is 46-51% to mammalian subtypes Y1, Y4 and Y6 and to zebrafish Ya, i....

journal_title：Biochemical and biophysical research communications

authors： Ringvall M,Berglund MM,Larhammar D

更新日期：1997-12-29 00:00:00

abstract：:Atrazine is a widely used triazine herbicide. Although controversy still exists, a number of recent studies have described its adverse effects on various animals including humans. Of particular interest is its effects on reproductive capacity. In this study, we investigated the mechanisms underlying the adverse effect...

journal_title：Biochemical and biophysical research communications

authors： Hase Y,Tatsuno M,Nishi T,Kataoka K,Kabe Y,Yamaguchi Y,Ozawa N,Natori M,Handa H,Watanabe H

更新日期：2008-02-01 00:00:00

abstract：:In order to study the relationship between insulin like growth factor-II (IGF-II) and interleukin-8 (IL-8) that are upregulated in psoriasis, we monitored IL-8 expression in IGF-II-treated human keratinocytes and explored the signaling pathways of IL-8 expression by IGF-II. IGF-II increased the IL-8 mRNA and protein l...

journal_title：Biochemical and biophysical research communications

authors： Kim HJ,Byun SJ,Kim TY

更新日期：2004-04-23 00:00:00

abstract：:Cell migration is a critical process during development, tissue repair, and cancer metastasis. It requires complex processes of cell adhesion, cytoskeletal dynamics, and force generation. Lis1 plays an important role in the migration of neurons, fibroblasts and other cell types, and is essential for normal development...

journal_title：Biochemical and biophysical research communications

authors： Jheng GW,Hur SS,Chang CM,Wu CC,Cheng JS,Lee HH,Chung BC,Wang YK,Lin KH,Del Álamo JC,Chien S,Tsai JW

更新日期：2018-03-11 00:00:00

abstract：:The 55- (H-UK) and 36-kDa forms (L-UK) of human urinary urokinase lost most of esterase activity toward acetyl-glycyl-L-lysine methyl ester upon reductive cleavage of 3 SS bonds with dithiothreitol in the presence of the competitive inhibitor, N alpha-benzoyl-L-arginine amide (BAA), bound to polyacrylyl azide with C16...

journal_title：Biochemical and biophysical research communications

authors： Miwa N,Obata Y,Suzuki A

更新日期：1983-04-29 00:00:00

abstract：:Mammalian homologues of the Drosophila trp gene have been invoked as the structural basis for the currents associated with capacitative Ca2+ entry (CCE) in many cell types. Trp homologues are members of a large protein family that may associate as channel subunits providing an explanation for the functional diversity ...

journal_title：Biochemical and biophysical research communications

authors： Garcia RL,Schilling WP

更新日期：1997-10-09 00:00:00

abstract：:Chromatin spatial organization is essential for transcriptional modulation and stabilization. The pattern of DNA distal interplay form the multiple topological associating domains (TADs), and further assemble the functional compartmentalization with open and expression-active chromatin ("A" compartments) or closed and...

journal_title：Biochemical and biophysical research communications

authors： Gong W,Liu Y,Qu H,Liu A,Sun P,Wang X

更新日期：2019-03-19 00:00:00

abstract：:To investigate the effect of ionophores on Cl- distribution in human erythrocyte suspensions, we measured the membrane potential by using 19F and 31P NMR methods. Incubation of human erythrocytes with 0.005 mM of the neutral ionophores valinomycin and nonactin resulted in membrane potentials of -21.2 and -17.8 mV in t...

journal_title：Biochemical and biophysical research communications

authors： Wittenkeller L,Mota de Freitas D,Ramasamy R

更新日期：1992-04-30 00:00:00

abstract：:Pathogenesis of Alzheimer's disease (AD) is characterized by accumulation of extracellular deposits of amyloid β-protein (Aβ) in the brain. The steady state level of Aβ in the brain is determined by the balance between its production and removal; the latter occurring through egress across blood and CSF barriers as wel...

journal_title：Biochemical and biophysical research communications

authors： Yamamoto N,Tanida M,Ono Y,Kasahara R,Fujii Y,Ohora K,Suzuki K,Sobue K

更新日期：2014-02-28 00:00:00

abstract：:Oligodendrocytes (OLGs) are cells from the central nervous system that synthesize, assemble, and maintain myelin, the multilamellar membrane that surrounds axons and facilitates the fast conduction of nerve impulses. We have shown that OLGs initiate their myelinogenic phenotype upon adhesion to GRASP, a heparin-bindin...

journal_title：Biochemical and biophysical research communications

authors： Szuchet S,Plachetzki DC,Eaton KS

更新日期：2001-05-18 00:00:00

abstract：:Our previously synthesized 37 compounds, which are 2,5,6-substituted benzoxazole, benzimidazole, benzothiazole, and oxazolo(4,5-b)pyridine derivatives, were tested for their eukaryotic DNA topoisomerase II inhibitory activity in cell free system and 28 were found to inhibit the topoisomerase II at an initial concentra...

journal_title：Biochemical and biophysical research communications

authors： Pinar A,Yurdakul P,Yildiz I,Temiz-Arpaci O,Acan NL,Aki-Sener E,Yalcin I

更新日期：2004-04-30 00:00:00

abstract：:We have previously reported that salmosin, a novel disintegrin, was isolated from Korean snake (Agkistrodon halys brevicaudus) venom and significantly inhibited solid tumor growth in mice by perturbation of tumor-specific angiogenesis via blocking alphavbeta3 integrin expressed on vascular endothelial cells. In this s...

journal_title：Biochemical and biophysical research communications

authors： Kang IC,Kim DS,Jang Y,Chung KH

更新日期：2000-08-18 00:00:00

abstract：:HL-60 nuclear autophosphorylation was studied in vitro under circumstances in which the conformation of chromatin was manipulated with both polyamines and DNAse-I. A general re-arrangement of the phosphorylation patterns occurred as polyamines were removed and nuclei were observed to expand. DNAse-I treatment reduced ...

journal_title：Biochemical and biophysical research communications

authors： Testori A,Skinner JD,Murray AW,Burgoyne LA

更新日期：1991-10-15 00:00:00

abstract：:Necrotic cells are known to develop characteristic membrane blebs. We measured protein concentration within necrotic blebs and found that it can be reduced by as much as twenty-fold compared to the main cell body (CB). These results raise two questions: 1. Why do proteins vacate the bleb? 2. How can osmotic equilibriu...

journal_title：Biochemical and biophysical research communications

authors： Rana PS,Mudrak NJ,Lopez R,Lynn M,Kershner L,Model MA

更新日期：2017-10-21 00:00:00

abstract：:A complementary DNA library prepared from the 12S polyadenylated RNAs extracted from interferon-induced KG-1 cells, a human myeloblast cell line, was screened for the presence of induction-specific sequences. Clones that exhibited strong positive signals were separated by hybridization criteria into nine classes. Clon...

journal_title：Biochemical and biophysical research communications

authors： Tsuzuki T,Nomiyama H,Setoyama C,Maeda S,Shimada K,Pestka S

更新日期：1983-07-29 00:00:00

abstract：:Escherichia coli isoleucyl-tRNA synthetase has been shown to contain two enzyme-bound zinc atoms per polypeptide chain. To investigate the structural and functional significance of the C-terminal enzyme-bound zinc, mutagenesis was used to alter Cys 922 to Ser [IleRS(C922S)] and to replace Cys 922 through Ala 939 with ...

journal_title：Biochemical and biophysical research communications

authors： Zhou L,Rosevear PR

更新日期：1995-11-13 00:00:00

abstract：:Under many physiological circumstances, Na(+)- and Cl(-)-dependent, hemicholinium-3 (HC-3)-sensitive, high-affinity choline uptake (HACU) in cholinergic neurons is thought to be rate-limiting in the biosynthesis of acetylcholine (ACh). Based on sequence information provided by the Human Genome Project and the recently...

journal_title：Biochemical and biophysical research communications

authors： Apparsundaram S,Ferguson SM,George AL Jr,Blakely RD

更新日期：2000-10-05 00:00:00

abstract：:Crystal structure of the complex between porcine beta-trypsin and the second domain of the Kazal-type ovomucoid turkey egg white trypsin inhibitor (OMTKY2) has been determined at 1.9A resolution. A peptide fragment from the first domain has been crystallized with the complex. Restrained-refinement of the structure led...

journal_title：Biochemical and biophysical research communications

authors： Ibrahim BS,Pattabhi V

更新日期：2004-01-02 00:00:00