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Oligodendrocyte transmembrane protein: a novel member of the glutamate-binding protein subfamily.

Abstract：

:Oligodendrocytes (OLGs) are cells from the central nervous system that synthesize, assemble, and maintain myelin, the multilamellar membrane that surrounds axons and facilitates the fast conduction of nerve impulses. We have shown that OLGs initiate their myelinogenic phenotype upon adhesion to GRASP, a heparin-binding glycoprotein that we purified from horse serum. In an attempt to identify the genes implicated in establishing this phenotype, we isolated a novel 3500 bp cDNA related to, but distinct from, a subfamily of glutamate-binding proteins (GBP). The cDNA encodes a protein of 511 amino acids, whose predicted sequence can be modeled as a tetrahelical integral protein with a large external loop and with the N- and C-termini located inside the cell. We have named this protein oligodendrocyte transmembrane protein (OTMP). Transcription of the message is induced upon OLG acquiring a myelinogenic phenotype (i.e., upon adhesion). The temporal expression in conjunction with the structural and biochemical features of OTMP is suggestive of a signaling receptor with a role in myelinogenesis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Szuchet S,Plachetzki DC,Eaton KS

doi

10.1006/bbrc.2001.4859

subject

Has Abstract

pub_date

2001-05-18 00:00:00

pages

900-7

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(01)94859-4

journal_volume

283

pub_type

杂志文章

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