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Association of restriction fragment length polymorphism at the atrial natriuretic peptide gene locus with aldosterone responsiveness to angiotensin in aldosterone-producing adenoma.

Abstract：

:Primary aldosteronism is an important, potentially curable, form of hypertension. We examined the possible association between restriction fragment length polymorphisms in the atrial natriuretic peptide (ANP) gene and responsiveness of aldosterone to angiotensin II in 59 patients with primary aldosteronism due to aldosterone-producing adenoma (APA). Significant differences in the allelic frequencies of the BglI, TaqI and XhoI polymorphic sites at the ANP gene locus (chromosome 1; 1p36) between angiotensin II-unresponsive and angiotensin II-responsive tumors were observed. Variation in the ANP gene between the two groups may result in altered expression of ANP within the adrenal gland, and may contribute to the biochemical regulation of aldosterone production of these two subgroups of patients with APA.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Tunny TJ,Jonsson JR,Klemm SA,Ballantine DM,Stowasser M,Gordon RD

doi

10.1006/bbrc.1994.2606

subject

Has Abstract

pub_date

1994-11-15 00:00:00

pages

1312-7

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)72606-4

journal_volume

204

pub_type

杂志文章

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