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Regulation of the type III InsP(3) receptor by InsP(3) and calcium.

Abstract：

:It has been proposed that the inositol 1,4,5-trisphosphate receptor (InsP(3)R) type III acts as a trigger for InsP(3)-mediated calcium (Ca(2+)) signaling, because this InsP(3) isoform lacks feedback inhibition by cytosolic Ca(2+). We tested this hypothesis in RIN-m5F cells, which express predominantly the type III receptor. Extracellular ATP increases Ca(2+) in these cells, and we found that this effect is independent of extracellular Ca(2+) but is blocked by the InsP(3)R antagonist heparin. There was a dose-dependent increase in the number of cells responding to ATP and two-photon flash photolysis of caged-Ca(2+) heightened the sensitivity of RIN-m5F cells to this increase. These findings provide evidence that Ca(2+) increases the sensitivity of the InsP(3)R type III in intact cells and supports the idea that this isoform can act as a trigger for hormone-induced Ca(2+) signaling.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

O'Neill AF,Hagar RE,Zipfel WR,Nathanson MH,Ehrlich BE

doi

10.1016/S0006-291X(02)00524-7

subject

Has Abstract

pub_date

2002-06-14 00:00:00

pages

719-25

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(02)00524-7

journal_volume

294

pub_type

杂志文章

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