当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Metastable primordial germ cell-like state induced from mouse embryonic stem cells by Akt activation.

Metastable primordial germ cell-like state induced from mouse embryonic stem cells by Akt activation.

Abstract：

:Specification to primordial germ cells (PGCs) is mediated by mesoderm-induction signals during gastrulation. We found that Akt activation during in vitro mesodermal differentiation of embryonic stem cells (ESCs) generated self-renewing spheres with differentiation states between those of ESCs and PGCs. Essential regulators for PGC specification and their downstream germ cell-specific genes were expressed in the spheres, indicating that the sphere cells had commenced differentiation to the germ lineage. However, the spheres did not proceed to spermatogenesis after transplantation into testes. Sphere cell transfer to the original feeder-free ESC cultures resulted in chaotic differentiation. In contrast, when the spheres were cultured on mouse embryonic fibroblasts or in the presence of ERK-cascade and GSK3 inhibitors, reversion to the ESC-like state was observed. These results indicate that Akt signaling promotes a novel metastable and pluripotent state that is intermediate to those of ESCs and PGCs.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yamano N,Kimura T,Watanabe-Kushima S,Shinohara T,Nakano T

doi

10.1016/j.bbrc.2010.01.005

subject

Has Abstract

pub_date

2010-02-12 00:00:00

pages

311-6

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(10)00027-6

journal_volume

392

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • A valine-to-lysine substitution at position 210 induces structural conversion of prion protein into a β-sheet rich oligomer.

    abstract：:Prion diseases are fatal neurodegenerative diseases associated with structural conversion of α-helical prion protein (PrP) into its β-sheet rich isoform (PrPSc). Previous genetic analyses have indicated that several amino acid residues involved in the hydrophobic core of PrP (such as V180, F198, and V210) play a criti...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.10.075

    authors： Kakuda K,Yamaguchi KI,Kuwata K,Honda R

    更新日期：2018-11-17 00:00:00

  • Cell cycle control of reverse transcriptase activity for the yeast retrotransposon Ty3.

    abstract：:Retroviruses and retrotransposons depend on their host cells to complete their replication cycles. In many cases, the viral step of reverse transcription is blocked when host cells are arrested in their cell cycle and this block is only released when the host cell resumes division. It has previously been shown that a ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.0128

    authors： Karst SM,Sadeghi N,Menees TM

    更新日期：1999-01-27 00:00:00

  • Transcription factor WRKY30 mediates resistance to Cucumber mosaic virus in Arabidopsis.

    abstract：:WRKY transcription factors are key regulators in regulating abiotic or biotic stress response in Arabidopsis. Previous studies showed that WRKY30 expression was induced by oxidative stress treatment, fungal elicitor, SA and ABA. However, functions of WRKY30 on viral defense are not well studied. Here, we found that Ar...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.07.030

    authors： Zou L,Yang F,Ma Y,Wu Q,Yi K,Zhang D

    更新日期：2019-09-10 00:00:00

  • Cardioprotective effects of recombinant human erythropoietin in rats with experimental autoimmune myocarditis.

    abstract：:Erythropoietin (EPO) has been known to have cytoprotective effects on several types of tissues, presumably through modulation of apoptosis and inflammation. The effect of EPO on myocardial inflammation, however, has not yet been clarified. We investigated the cardioprotective effects of EPO in rats with experimental a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.03.230

    authors： Mitsuma W,Ito M,Kodama M,Fuse K,Okamura K,Minagawa S,Kato K,Hanawa H,Toba K,Nakazawa M,Aizawa Y

    更新日期：2006-06-09 00:00:00

  • Defective GATA-3 expression in Th2 LCR-deficient mice.

    abstract：:Th2 cell differentiation is critically influenced by transcription factor GATA-3 and by various cis-acting elements including enhancers, silencers and a locus control region (LCR) in the Th2 cytokine locus. Th2 LCR-deficient Th2 cells completely lost the expression of GATA-3 and the phosphorylation of STAT6. Histone 3...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.06.080

    authors： Hwang SS,Kim K,Lee GR

    更新日期：2011-07-15 00:00:00

  • PhyA gene product of Aspergillus ficuum and Peniophora lycii produces dissimilar phytases.

    abstract：:PhyA gene products of Aspergillus ficuum (AF) and Peniophora lycii (PL) as expressed in industrial strains of Aspergillus niger and Aspergillus oryzae, respectively, were purified to homogeneity and then characterized for both physical and biochemical properties. The PL phytase is 26 amino acid residues shorter than t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)00374-7

    authors： Ullah AH,Sethumadhavan K

    更新日期：2003-04-04 00:00:00

  • Histone-H1 inhibits translation by reticulocyte lysates with relative mRNA selectivity.

    abstract：:Histone-H1 purified from rat skeletal muscle is a relatively potent inhibitor of peptide chain initiation in a cell free system, the rabbit reticulocyte lysate (50% inhibition at approximately 0.4 microM). H1 does not inhibit formation of the ternary complex nor its attachment to 40S ribosomes; the data are compatible...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(87)80514-4

    authors： O'Leary NE,Cheema IR,Moore K,Mehard WB,Buse MG

    更新日期：1987-04-14 00:00:00

  • Stimulation of phospholipid methylation by glucose in pancreatic islets.

    abstract：:A two fold stimulation in the incorporation of [3H-methyl] groups from [3H-methyl] methionine into phospholipids was seen in intact pancreatic islets within six minutes of exposure to a glucose concentration that stimulates insulin release. Nonstimulatory sugars, L-glucose and D-galactose, as well as dibutyryl cAMP, d...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(84)80091-1

    authors： Kowluru A,Rana RS,MacDonald MJ

    更新日期：1984-07-31 00:00:00

  • Genetic characterization of an Escherichia coli mutant deficient in organophosphonate biodegradation.

    abstract：:An E. coli mutant deficient in organophosphonate biodegradation has been complemented with a cosmid library prepared from a BamHI partial digest of wild-type E. coli W3110. Mutant E. coli SL724, when transformed with cosmid pSL163 and plasmid pSL263, regained the ability to exploit ethylphosphonate as a sole source of...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91088-6

    authors： Loo SH,Peters NK,Frost JW

    更新日期：1987-10-14 00:00:00

  • MicroRNA involvement in glioblastoma pathogenesis.

    abstract：:MicroRNAs are endogenously expressed regulatory noncoding RNAs. Altered expression levels of several microRNAs have been observed in glioblastomas. Functions and direct mRNA targets for these microRNAs have been relatively well studied over the last years. According to these data, it is now evident, that impairment of...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2009.06.034

    authors： Novakova J,Slaby O,Vyzula R,Michalek J

    更新日期：2009-08-14 00:00:00

  • Role of Flightless-I (Drosophila) homolog in the transcription activation of type I collagen gene mediated by transforming growth factor beta.

    abstract：:Flightless-I (Drosophila) homolog (FLII) is a nuclear receptor coactivator that is known to interact with other transcriptional regulators such as the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, at the promoter or enhancer region of estrogen receptor (ER)-α target genes. However, little is known ab...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.10.100

    authors： Lim MS,Jeong KW

    更新日期：2014-11-21 00:00:00

  • Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABAA receptors and shows hypnotic effects.

    abstract：:Isoliquiritigenin (ILTG) is a chalcone compound and has valuable pharmacological properties such as antioxidant, anti-inflammatory, anticancer, and antiallergic activities. Recently, the anxiolytic effect of ILTG has been reported; however, its action mechanism and hypnotic activity have not yet been demonstrated. The...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.09.026

    authors： Cho S,Kim S,Jin Z,Yang H,Han D,Baek NI,Jo J,Cho CW,Park JH,Shimizu M,Jin YH

    更新日期：2011-10-07 00:00:00

  • Two forms of AMP deaminase from chicken liver.

    abstract：:Chromatography of chicken liver AMP deaminase on phosphocellulose and DEAE-Sephacel revealed the existence of two separate peaks of enzyme activity. Significant differences have been observed between form I and II of the enzyme in respect to substrate specificity and their kinetic and regulatory properties. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)90662-9

    authors： Spychała J,Makarewicz W

    更新日期：1983-08-12 00:00:00

  • Generation of insulin-secreting cells from adult rat pancreatic ductal epithelial cells induced by hepatocyte growth factor and betacellulin-delta4.

    abstract：:The present study was conducted to identify effective factors that could induce differentiation of pancreatic ductal epithelial cells (PDECs) into insulin-producing cells. We examined the effect of hepatocyte growth factor (HGF) and betacellulin-delta4 (BTC-delta4) on PDECs. We isolated PDECs from adult rats and stimu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.03.029

    authors： Zhan XR,Li XY,Liu XM,Zhou JH,Yang YL,Yi R,Zhang J,Yang BF

    更新日期：2009-05-01 00:00:00

  • Inactivation of human blood coagulation factor X by chemical modification of gamma-carboxyglutamic acid residues.

    abstract：:The inactivation of human factor X by incubation with a reagent known to chemically modify gamma-carboxyglutamic acid to gamma-methylene glutamic acid was studied. Incubation of factor X at pH 5.0 with a preincubated formaldehyde/morpholine mixture (0.9 M/1.0 M) resulted in a progressive decrease in factor X coagulant...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)90945-8

    authors： Sherrill GB,Straight DL,Hiskey RG,Roberts HR,Griffith MJ

    更新日期：1984-10-15 00:00:00

  • Oleate and eicosapentaenoic acid attenuate palmitate-induced inflammation and apoptosis in renal proximal tubular cell.

    abstract：:Free fatty acid (FFA)-bound albumin, which is filtrated through the glomeruli and reabsorbed into proximal tubular cells, is one of the crucial mediators of tubular damage in proteinuric kidney disease. In this study, we examined the role of each kind of FFA on renal tubular damage in vitro and tried to identify its m...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.10.012

    authors： Soumura M,Kume S,Isshiki K,Takeda N,Araki S,Tanaka Y,Sugimoto T,Chin-Kanasaki M,Nishio Y,Haneda M,Koya D,Kashiwagi A,Maegawa H,Uzu T

    更新日期：2010-11-12 00:00:00

  • Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split.

    abstract：:In this report we describe the initial characterization of murine, human, and Drosophila hesr-1 (for hairy and enhancer of split related-1) a novel evolutionary conserved family of hairy/enhancer of split homologs. Hesr-1 cDNAs display features typical of hairy and enhancer of split-type bHLH proteins including a N-te...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0880

    authors： Kokubo H,Lun Y,Johnson RL

    更新日期：1999-07-05 00:00:00

  • Cyclic AMP is an essential factor in immune responses.

    abstract：:In the present studies, cAMP, a secondary messenger historically viewed as a negative mediator of immune responses, was demonstrated to possess immunoenhancing activity at low concentrations. In parallel experiments the adenylate cyclase inhibitor, 2',3'-dideoxyadenosine, produced a marked inhibition of humoral and pr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1099

    authors： Koh WS,Yang KH,Kaminski NE

    更新日期：1995-01-17 00:00:00

  • Green tea epigallocatechin-3-gallate inhibits microsomal prostaglandin E(2) synthase-1.

    abstract：:Prostaglandin (PG)E(2) is a critical lipid mediator connecting chronic inflammation to cancer. The anti-carcinogenic epigallocatechin-3-gallate (EGCG) from green tea (Camellia sinensis) suppresses cellular PGE(2) biosynthesis, but the underlying molecular mechanisms are unclear. Here, we investigated the interference ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.08.005

    authors： Koeberle A,Bauer J,Verhoff M,Hoffmann M,Northoff H,Werz O

    更新日期：2009-10-16 00:00:00

  • Expression of p40/Epstein-Barr virus nuclear antigen 1 binding protein 2.

    abstract：:Nucleolar protein p40/EBP2 is a proliferation-associated antigen that interacts with Epstein-Barr virus nuclear antigen 1 (EBNA1) to maintain the Epstein-Barr virus (EBV) episomes. The yeast p40/EBP2 functions in the processing of 27S-A into 27S-B ribosomal RNA. The present study reports high evolutionary conservation...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4780

    authors： Henning D,Valdez BC

    更新日期：2001-05-04 00:00:00

  • Distribution of 1,25-dihydroxyvitamin D3 receptor and 25-hydroxyvitamin D3-24-hydroxylase mRNA expression along rat nephron segments.

    abstract：:Distribution of mRNA expression of 1,25-dihydroxyvitamin D3 receptor (VDR) and 25-hydroxyvitamin D3-24-hydroxylase (24-OHase) along the microdissected rat nephron segments was examined by reverse transcription-polymerase chain reaction (RT-PCR) technique. VDR mRNA was abundantly expressed in cortical segments (glomeru...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1872

    authors： Iida K,Taniguchi S,Kurokawa K

    更新日期：1993-07-30 00:00:00

  • A novel insertion of a rearranged L1 element in exon 44 of the dystrophin gene: further evidence for possible bias in retroposon integration.

    abstract：:L1 elements are mammalian retrotransposons contributing to genome evolution and causing rare mutations in human. We describe a de novo insertion of an L1 element into the dystrophin gene resulting in skipping of exon 44 and causing Duchenne muscular dystrophy in a boy. The L1 element was rearranged due to the twin-pri...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.06.071

    authors： Musova Z,Hedvicakova P,Mohrmann M,Tesarova M,Krepelova A,Zeman J,Sedlacek Z

    更新日期：2006-08-18 00:00:00

  • Binding and effect of atrial natriuretic factor on cyclic GMP formation and alpha-MSH secretion of intermediate pituitary cells.

    abstract：:The present study shows for the first time that in proopiomelanocortin cells of the rat intermediate pituitary gland ANF binds to two receptor forms, with apparent molecular weights of 150K and 70K. Scatchard plots revealed specific and high affinity non-interacting sites, with a KD value of about 3 nM and a density o...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)81052-0

    authors： Lutz-Bucher B,Boudjada T,Heisler S,Pelletier G,Koch B

    更新日期：1988-08-30 00:00:00

  • Amantadine- and oseltamivir-resistant variants of influenza A viruses in Thailand.

    abstract：:Amantadine and oseltamivir are used to treat influenza A virus infections; however, resistance to these drugs has been widely reported throughout the world. In this study, the frequency and genetic characteristics of the drug-resistant influenza A viruses that circulated in Thailand from 2006 to 2008 were investigated...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.10.071

    authors： Bai GR,Chittaganpitch M,Kanai Y,Li YG,Auwanit W,Ikuta K,Sawanpanyalert P

    更新日期：2009-12-18 00:00:00

  • The sequence of sites recognised by a member of the RNase E/G family can control the maximal rate of cleavage, while a 5'-monophosphorylated end appears to function cooperatively in mediating RNA binding.

    abstract：:Members of the RNase E/G family are multimeric, 5'-end-sensing, single-strand-specific endoribonucleases that are found in chloroplasts as well as bacteria, and have central roles in RNA processing and degradation. A well-studied member of this family is Escherichia coli RNase G. Recently, we have shown that the inter...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.11.156

    authors： Jourdan SS,Kime L,McDowall KJ

    更新日期：2010-01-01 00:00:00

  • Active-site probes of carnitine acyltransferases. Inhibition of carnitine acetyltransferase by hemiacetylcarnitinium, a reaction intermediate analogue.

    abstract：:Hemiacetylcarnitinium (2S,6R:2R,65)-6-carboxymethyl-2-hydroxy-2,4,4- trimethylmorpholinium) chloride is a relatively potent competitive inhibitor (Ki = 0.89 mM) of pigeon breast carnitine acetyltransferase (CAT) and of the crude rat liver CAT (Ki = 4.72 mM) but is neither an inhibitor nor an effective substrate for pu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80558-7

    authors： Gandour RD,Colucci WJ,Stelly TC,Brady PS,Brady LJ

    更新日期：1986-07-31 00:00:00

  • Repression of Smad3 activity by histone demethylase SMCX/JARID1C.

    abstract：:SMCX/JARID1C was recently shown to be a histone H3 lysine 4 (H3K4) demethylase. Here, we have identified an SMCX isoform that predominantly resides in the cytoplasm, but still efficiently demethylates trimethylated H3K4. SMCX requires several functional domains for its demethylase activity and is also capable of formi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.12.013

    authors： Kim TD,Shin S,Janknecht R

    更新日期：2008-02-08 00:00:00

  • Factor C-LHIH which inhibits the luteinizing hormone from basal release and from synthetic LHRH and studies on purification of FSHRH.

    abstract：:Data on a new entity which inhibits the release of luteinizing hormone (LH), designated as factor C-LHIH, are presented. In vitro assays were carried out with pituitary glands from female rats. Factor C-LHIH and follicle stimulating hormone releasing hormone (FSHRH) initially fractionated together. FSHRH obscured C...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(75)80011-8

    authors： Johansson KN,Greibrokk T,Currie BL,Hansen J,Folkers K

    更新日期：1975-03-03 00:00:00

  • Secondary structure formation is the earliest structural event in the refolding of an all beta-sheet protein.

    abstract：:The refolding kinetics of cobrotoxin (CBTX), a small-molecular-weight ( approximately 7 kDa) all beta-sheet protein, has been monitored using a variety of biophysical techniques. The secondary structure formation and hydrophobic collapse occur as distinct events during the refolding of the protein. Complete secondary ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0901

    authors： Sivaraman T,Kumar TK,Tu YT,Wang W,Lin WY,Chen HM,Yu C

    更新日期：1999-06-24 00:00:00

  • Effects of inhibiting transglutaminase during egg fertilization and development.

    abstract：:Transglutaminase inhibitor (1,3,4,5-tetramethyl-2-[(2-oxopropyl)thio]imidazolium chloride or L-682777) affected the appearance of the fertilization envelope (FE) and subsequent development in Sphaerechinus granularis and Arbacia punctulata in a concentration-dependent manner. Abnormalities were first visible in formin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2702

    authors： Cariello L,Zanetti L,Lorand L

    更新日期：1994-11-30 00:00:00