Secondary structure formation is the earliest structural event in the refolding of an all beta-sheet protein.

abstract：:Structural class characterizes the overall folding type of a protein or its domain. This paper develops an accurate method for in silico prediction of structural classes from low homology (twilight zone) protein sequences. The proposed LLSC-PRED method applies linear logistic regression classifier and a custom-designe...

journal_title：Biochemical and biophysical research communications

authors： Kurgan L,Chen K

更新日期：2007-06-01 00:00:00

abstract：:Copper is a micronutrient that is required for proper metabolic functioning of most prokaryotic and eukaryotic organisms. To sustain an adequate supply of copper, a cell requires molecular mechanisms that control the metal content to avoid copper toxicity. This toxicity comes primarily from the reactivity of copper, w...

journal_title：Biochemical and biophysical research communications

authors： Latorre M,Olivares F,Reyes-Jara A,López G,González M

更新日期：2011-03-25 00:00:00

abstract：:The preferred dye binding sites and the microenvironment of known nucleotide sequences within mitochondrial and plasmid pBR322 DNA was probed in a gross fashion with restriction endonucleases. The intercalating dyes, ethidium bromide and propidium iodide, do not inhibit a given restriction endonuclease equally at all ...

journal_title：Biochemical and biophysical research communications

authors： Soslau G,Pirollo K

更新日期：1983-09-15 00:00:00

abstract：:Cholinesterases in the oat cell were found to be distributed in the cell wall (50%) and cytoplasm (42%). Activity of the cytosolic enzyme was inhibited about 80% by 1 mM Ca2+. The enzyme activity was also inhibited by Mn2+, but no inhibition by Mg2+ was observed. Effects of red light and calcium ion on the enzyme acti...

journal_title：Biochemical and biophysical research communications

authors： Kim HY,Kim TI,Kim HK,Chae Q

更新日期：1990-05-31 00:00:00

abstract：:The tetracycline-regulated gene expression system has been widely used in mice to turn a transgene on and off in a target organ, but with only limited success. We developed an advanced system in which a Tet-off regulation unit was integrated into the ROSA26 locus and became active after Cre-mediated excision of the ne...

journal_title：Biochemical and biophysical research communications

authors： Miyazaki S,Miyazaki T,Tashiro F,Yamato E,Miyazaki J

更新日期：2005-12-16 00:00:00

abstract：:The reaction of the crosslinker dibromobimane has recently revealed a functionally important internal loop structure within the skeletal myosin S1 heavy chain where Cys-522 of the 50K domain and Cys-707 (SH1) of the 20K region are spatially juxtaposed. Here we have studied the possible relevance of this topological fe...

journal_title：Biochemical and biophysical research communications

authors： Bonet A,Audemard E,Mornet D

更新日期：1988-04-15 00:00:00

abstract：:The codon-reading properties of wobble-position variants of the unmodified form of Escherichia coli tRNASer1 (the UGA anticodon) were measured in a cell-free translation system. Two variants, with the AGA and CGA anticodons, each exclusively read a single codon, UCU and UCG, respectively. The only case of efficient wo...

journal_title：Biochemical and biophysical research communications

authors： Takai K,Takaku H,Yokoyama S

更新日期：1999-04-21 00:00:00

abstract：:Although TRPV1 and TRPM8 agonists (vanilloid capsaicin and menthol, respectively) at high concentrations inhibit action potential conduction, it remains to be unknown whether TRPA1 agonists have a similar action. The present study examined the actions of TRPA1 agonists, cinnamaldehyde (CA) and allyl isothiocyanate (AI...

journal_title：Biochemical and biophysical research communications

authors： Matsushita A,Ohtsubo S,Fujita T,Kumamoto E

更新日期：2013-04-26 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most frequent cancer in numerous of countries worldwidely. The initiation and progression of CRC is an extremely complex process, and have been suggested a correlation with Long non-coding RNAs (lncRNAs). Our results showed that lncRNA-422(ENST00000415820) significantly downregula...

journal_title：Biochemical and biophysical research communications

authors： Shao Q,Xu J,Deng R,Wei W,Zhou B,Yue C,Zhu M,Huang X,Zhu H

更新日期：2018-01-01 00:00:00

abstract：:Cripto-1 (CR-1) is a transforming growth factor which has been associated with breast, colon, and pancreatic cancer. Overexpression of CR-1 in non-tumorigenic mouse mammary epithelial cells and fibroblasts results in an increase in anchorage-dependent and -independent growth in vitro. Reduction of CR-1 expression in h...

journal_title：Biochemical and biophysical research communications

authors： Kintner RL,Hosick HL

更新日期：1998-04-28 00:00:00

abstract：:The Cucumber mosaic virus (CMV)-encoded 1a protein has been implicated to play a role in replication of the viral genome along with 2a and one or more host factors. To identify the host cell factors interacting with CMV 1a, we used the yeast two-hybrid system using tobacco cDNA library. One of the cDNA clones encoded ...

journal_title：Biochemical and biophysical research communications

authors： Kim MJ,Ham BK,Paek KH

更新日期：2006-02-03 00:00:00

abstract：:Amyloid β (Aβ) oligomers may be a real culprit in the pathogenesis of Alzheimer's disease (AD); therefore, the elimination of these toxic oligomers may be of great significance for AD therapy. Autophagy is the catabolic process by which lysosomes degrade cytosolic components, and heat shock cognate 70 kDa protein (Hsc...

journal_title：Biochemical and biophysical research communications

authors： Dou J,Su P,Xu C,Wen Z,Mao Z,Li W

更新日期：2020-04-16 00:00:00

abstract：:Protein synthesis and degradation balance have a crucial role in maintenance of cellular homeostasis and function. The ubiquitin-proteasome system is one of the major cellular proteolytic machineries responsible for the removal of normal, abnormal, denatured or in general damaged proteins. Proteasome is a multisubunit...

journal_title：Biochemical and biophysical research communications

authors： Sakellari M,Chondrogianni N,Gonos ES

更新日期：2019-06-18 00:00:00

abstract：:Human apoprotein(apo) CI and apo AII cDNA probes have been used to analyze the segregation of the human genes in panels of human-mouse hybrids. The apo CI (APOCI) gene segregates with chromosome 19 and the apo AII (APOA2) gene with chromosome 1. Somatic cell hybrids containing chromosome translocations were used to ma...

journal_title：Biochemical and biophysical research communications

authors： Knott TJ,Eddy RL,Robertson ME,Priestley LM,Scott J,Shows TB

更新日期：1984-11-30 00:00:00

abstract：:CRAMP-18 (GEKLKKIGQKIKNFFQKL) is the antibacterial sequence derived from CRMAP, a member of cathelicidin-derived antimicrobial peptides. To develop the novel antibiotic peptides useful as therapeutic drugs requires strong antibiotic activity against bacterial and fungal cells without hemolytic effect. To this goal, th...

journal_title：Biochemical and biophysical research communications

authors： Shin SY,Kang SW,Lee DG,Eom SH,Song WK,Kim JI

更新日期：2000-09-07 00:00:00

abstract：:Fourteen kb murine GLUT4 minigene (= -7395 GLUT4) contains DNA sequence that confers tissue specific, exercise-induced up-regulation of the GLUT4 gene in skeletal muscle and high-fat diet induced-down-regulation in white adipose tissue. To identify the DNA sequences required for regulated expression, we generated GLUT...

journal_title：Biochemical and biophysical research communications

authors： Tsunoda N,Cooke DW,Ikemoto S,Maruyama K,Takahashi M,Lane MD,Ezaki O

更新日期：1997-10-20 00:00:00

abstract：:The retinoblastoma gene product (pRB) has been known to contain a sequence-nonspecific DNA binding activity. It is unknown whether pRB can recognize and bind to specific DNA sequences. We have recently identified a rat genomic DNA fragment, termed REC11, which can interact with rat Cdc37-related protein (RCdc37). In t...

journal_title：Biochemical and biophysical research communications

authors： Ozaki T,Sakiyama S

更新日期：1996-09-04 00:00:00

abstract：:Bcl10 is a signaling protein required for activation of the NF-kappaB transcription factor. NF-kappaB is an important mediator of genotoxic stress and regulates the expression of genes required for both cell proliferation and cell death. Bcl10 is phosphorylated in vivo, however, the protein kinase or kinases responsib...

journal_title：Biochemical and biophysical research communications

authors： Bodero AJ,Ye R,Lees-Miller SP

更新日期：2003-02-21 00:00:00

abstract：:Subcellular distribution of a novel annexin, annexin XI, was examined in rat tissues. As we have previously reported, annexin XI mainly localizes in nuclei of 3Y1, the rat embryonic fibroblast cell line; however, immunoperoxidase staining was not particularly nuclear in most of the tissues examined in adult rats. Nucl...

journal_title：Biochemical and biophysical research communications

authors： Mamiya N,Iino S,Mizutani A,Kobayashi S,Hidaka H

更新日期：1994-07-15 00:00:00

abstract：:Recent years have seen considerable evolution in our understanding of the mechanisms of oxygen activation by non-heme iron enzymes, with high-valent iron-oxo intermediates coming to the forefront as formidably potent oxidants. In the absence of substrate, the generation of vividly colored chromophores deriving from th...

journal_title：Biochemical and biophysical research communications

authors： Farquhar ER,Koehntop KD,Emerson JP,Que L Jr

更新日期：2005-12-09 00:00:00

abstract：:In the presence of copper (Cu), disulfiram (DSF) suppresses properties associated with cancer stem cells (CSCs) in breast cancer, but the mechanism of action is poorly understood. In the present study, we observed that DSF/Cu treatment induced apoptosis, mediated by caspase-3 activation in triple-negative breast cance...

journal_title：Biochemical and biophysical research communications

authors： Kim YJ,Kim JY,Lee N,Oh E,Sung D,Cho TM,Seo JH

更新日期：2017-05-13 00:00:00

abstract：:Ultrasound (US) has emerged as a promising noninvasive modality for neuromodulation. Despite previous evidence that US may mediate cellular response by activating mechanosensitive ion channels embedded in the cell membrane, the underlying mechanism is not well understood. In this work, we developed a vertically deploy...

journal_title：Biochemical and biophysical research communications

authors： Liao D,Li F,Lu D,Zhong P

更新日期：2019-10-20 00:00:00

abstract：:Synthesis of ABCA1 protein in liver is necessary for high-density lipoproteins (HDL) formation in mammals. Nuclear receptor PPARγ is known as activator of ABCA1 expression, but details of PPARγ-mediated regulation of ABCA1 at both transcriptional and post-transcriptional levels in hepatocytes have not still been well ...

journal_title：Biochemical and biophysical research communications

authors： Mogilenko DA,Shavva VS,Dizhe EB,Orlov SV,Perevozchikov AP

更新日期：2010-11-19 00:00:00

abstract：:CMP-Kdn synthetase catalyses the reaction of sialic acids (Sia) and cytidine-5'-triphosphate (CTP) to the corresponding activated sugar nucleotide CMP-Sia and pyrophosphate PP(i). STD NMR experiments of a recombinant nucleotide cytidine-5'-monophosphate-3-deoxy-d-glycero-d-galacto-nonulosonic acid synthetase (CMP-Kdn ...

journal_title：Biochemical and biophysical research communications

authors： Haselhorst T,Münster-Kühnel AK,Stolz A,Oschlies M,Tiralongo J,Kitajima K,Gerardy-Schahn R,von Itzstein M

更新日期：2005-02-11 00:00:00

abstract：:Guanylin and uroguanylin are structurally related intestinal peptide hormones which were purified from a limited number of mammals and are capable of activating the particulate guanylate cyclase-C. Although the biological functions of guanylin and uroguanylin are not yet clarified in detail, they are involved in the r...

journal_title：Biochemical and biophysical research communications

authors： Mägert HJ,Hill O,Zucht HD,Martin S,Meyer M,Forssmann WG,Adermann K

更新日期：1999-05-27 00:00:00

abstract：:The relation of expression of the LF-B1 gene with the L-type pyruvate kinase (L-PK) mRNA level in rat liver and hepatoma cells was investigated. The L-PK mRNA level in rat liver changed after partial hepatectomy, during development and on intake of a high carbohydrate diet, while the level of LF-B1 mRNA remained uncha...

journal_title：Biochemical and biophysical research communications

authors： Imai E,Noguchi T,Takenaka M,Yamada K,Matsuda T,Monaci P,Nicosia A,Tanaka T

更新日期：1991-05-15 00:00:00

abstract：:To analyse the species of genes expressed in a cleavage stage mouse embryo, we have constructed a cDNA library containing 3.0 x 10(5) independent clones from about 2 x 10(3) embryos at the 8-cell stage of development. Endo A cDNA prepared from parietal yolk sac endoderm like PYS-2 cells was used to screen the library....

journal_title：Biochemical and biophysical research communications

authors： Nozaki M,Murata K,Morita T,Matsushiro A

更新日期：1988-08-15 00:00:00

abstract：:Plucked (pk) is an autosomal recessive mouse mutation with a hair phenotype that arose spontaneously in the DBA/2J strain. Histological studies indicate that adult pk mutant mice lose truncal hair because of the scarring of follicles due to an apparent obstruction of the outward movement of the hair shaft within the f...

journal_title：Biochemical and biophysical research communications

authors： Luo J,Zhang L,Stenn K,Prouty S,Parimoo S

更新日期：2005-02-04 00:00:00

abstract：:We identified a DNA polymerase species in Drosophila melanogaster embryos, and purified it. This polymerase shared some common properties with DNA polymerase epsilon from mammals and yeast as follows; it has a preference for poly(dA)/oligo(dT) as a template/primer, it is highly processive in DNA synthesis, it co-fract...

journal_title：Biochemical and biophysical research communications

authors： Aoyagi N,Oshige M,Hirose F,Kuroda K,Matsukage A,Sakaguchi K

更新日期：1997-01-13 00:00:00

abstract：:Aurora-C, a member of the Aurora kinase family, is implicated in the regulation of mitosis. In contrast to Aurora-A and Aurora-B its cellular localization and functions are poorly characterized. TACC1 protein belongs to the transforming acidic coiled-coil family shown to interact with the Aurora kinases. In the presen...

journal_title：Biochemical and biophysical research communications

authors： Gabillard JC,Ulisse S,Baldini E,Sorrenti S,Cremet JY,Coccaro C,Prigent C,D'Armiento M,Arlot-Bonnemains Y

更新日期：2011-05-20 00:00:00