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Long non-coding RNA-422 acts as a tumor suppressor in colorectal cancer.

Abstract：

:Colorectal cancer (CRC) is one of the most frequent cancer in numerous of countries worldwidely. The initiation and progression of CRC is an extremely complex process, and have been suggested a correlation with Long non-coding RNAs (lncRNAs). Our results showed that lncRNA-422(ENST00000415820) significantly downregulated in the tissues and serum of CRC patients, and is closely associated with the poor prognosis. Then gain or loss of lncRNA-422 models in SW480 and SW620cells were established. The results showed that lncRNA-422 overexpression inhibited cell proliferation, migration, and invasion. Knockdown of lncRNA-422 promoted tumorigensis. Western blot and qRT-PCR were performed to examine the activity of the PI3K/AKT/mTOR pathway in CRC cells after alternation of lncRNA-422. Results showed that lncRNA-422 acts as a tumor suppressor by PI3K/AKT/mTOR pathway in CRC.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Shao Q,Xu J,Deng R,Wei W,Zhou B,Yue C,Zhu M,Huang X,Zhu H

doi

10.1016/j.bbrc.2017.10.076

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

539-545

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(17)32054-5

journal_volume

495

pub_type

杂志文章

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