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Regulation of pituitary growth hormone-releasing factor (GRF) receptor gene expression by GRF.

Abstract：

:We examined how growth hormone-releasing factor (GRF) regulated pituitary GRF receptor gene expression in the conscious rat. GRF receptor mRNA levels were significantly increased by immunoneutralization of endogenous GRF with its specific antiserum. This effect was dose dependent and the maximum level was 3.8-fold higher than that in control rats. A similar rise in GRF receptor gene expression was obtained by the depletion of noradrenaline, a neurotransmitter thought to stimulate GRF release, and was reversed by 87% by the repeated administration of synthetic GRF. These results indicate that pituitary GRF receptor gene expression was up- or down-regulated in vivo in the absence or presence of GRF, respectively.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Miki N,Ono M,Murata Y,Ohsaki E,Tamitsu K,Yamada M,Demura H

doi

10.1006/bbrc.1996.1068

subject

Has Abstract

pub_date

1996-07-16 00:00:00

pages

586-90

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(96)91068-2

journal_volume

224

pub_type

杂志文章

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