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Identification of the AQP8-miR-92a network associated with the aggressive traits of colorectal cancer.

Abstract：

:Even though earlier reports have revealed that Aquaporin 8 (AQP8) exert essential roles in diverse malignancies, its relationship between specific microRNAs (miRNAs) in regulation of colorectal carcinoma (CRC) progression has never been elaborated. Herein, we proved that AQP8 was downregulated in CRC and high level of AQP8 was significantly associated with better survival in CRC patients. Overexpression of AQP8 restrained CRC cell proliferation, migration and invasion capacities in vitro. In vivo, upregulation of AQP8 also suppressed CRC cell growth. Mechanistic analyses illustrated that AQP8 was a directly target of miR-92a. The expression of AQP8 was negatively modulated by miR-92a. Rescues analysis indicated that miR-92a facilitated CRC cell growth and invasion via modulating the expression of AQP8. Our work validated that miR-92a regulated the aggressiveness of CRC cell via targeting AQP8.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Zhang H,Du WB,Guo XM,Wang LK,Cheng JM,Wei LJ

doi

10.1016/j.bbrc.2020.04.055

subject

Has Abstract

pub_date

2020-06-18 00:00:00

pages

218-225

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(20)30782-8

journal_volume

527

pub_type

杂志文章

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