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Inactivation of human blood coagulation factor X by chemical modification of gamma-carboxyglutamic acid residues.

Abstract：

:The inactivation of human factor X by incubation with a reagent known to chemically modify gamma-carboxyglutamic acid to gamma-methylene glutamic acid was studied. Incubation of factor X at pH 5.0 with a preincubated formaldehyde/morpholine mixture (0.9 M/1.0 M) resulted in a progressive decrease in factor X coagulant activity. In the presence of calcium (20 mM) the rate of factor X inactivation was decreased -3-fold. By using [14]C-formaldehyde, modified-factor X (less than 5% residual activity) was found to contain 7 mols of [14]C per mol of protein. Modified-factor X was not activated by Russell's viper venom in the presence of calcium, suggesting that the loss of coagulant activity was related to the inability of modified-factor X to be activated.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sherrill GB,Straight DL,Hiskey RG,Roberts HR,Griffith MJ

doi

10.1016/0006-291x(84)90945-8

subject

Has Abstract

pub_date

1984-10-15 00:00:00

pages

256-61

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(84)90945-8

journal_volume

124

pub_type

杂志文章

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