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Factor C-LHIH which inhibits the luteinizing hormone from basal release and from synthetic LHRH and studies on purification of FSHRH.

Abstract：

:Data on a new entity which inhibits the release of luteinizing hormone (LH), designated as factor C-LHIH, are presented. In vitro assays were carried out with pituitary glands from female rats. Factor C-LHIH and follicle stimulating hormone releasing hormone (FSHRH) initially fractionated together. FSHRH obscured C-LHIH, and FSH assays guided fractionation. Factor C-LHIH and FSHRH were separated and purified by Sephadex and high pressure liquied chromatography. The resulting fractions of C-LHIH inhibited LH-release at 100-500 ng and did not inhibit thyrotropin releasing hormone-thyroid stimulating hormone response.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Johansson KN,Greibrokk T,Currie BL,Hansen J,Folkers K

doi

10.1016/s0006-291x(75)80011-8

subject

Has Abstract

pub_date

1975-03-03 00:00:00

pages

62-8

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(75)80011-8

journal_volume

63

pub_type

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