Interleukin-1: a cytokine that has potent antisecretory and anti-ulcer actions via the central nervous system.

abstract：:Phosphorylation of membranes from murine erythroleukemia cells was performed in the presence and absence of the polar solvent dimethyl sulfoxide. Quantitation of the phosphoamino acid content revealed that DMSO stimulated phosphotyrosine accumulation by three-fold; serine and threonine phosphorylation decreased signif...

journal_title：Biochemical and biophysical research communications

authors： Earp HS,Rubin RA,Austin KS,Dy RC

更新日期：1983-04-29 00:00:00

abstract：:Nikkomycins act as a competitive inhibitor of chitin synthetase and display potent activities against phytopathogenic and human pathogenic fungi. sanT is located in the gene cluster of nikkomycin biosynthesis in Streptomyces ansochromogenes. Sequence analysis revealed that the deduced product of sanT has an unusual do...

journal_title：Biochemical and biophysical research communications

authors： Jia L,Tian Y,Tan H

更新日期：2007-11-03 00:00:00

abstract：:Microglia, brain macrophages, are thought to be the primary target of HIV-1 infection in the brain, because they exclusively express the CD4 antigen which is effectively used for viral entry. The expression of CD4 mRNA in cultured microglia could be detected by the reverse-PCR method. Using this and immunohistochemica...

journal_title：Biochemical and biophysical research communications

authors： Sawada M,Suzumura A,Marunouchi T

更新日期：1992-12-15 00:00:00

abstract：:Aberrant overexpression of the transcription/translation factor Y-box-binding protein-1 (YBX1) is associated with non-small cell lung cancer (NSCLC) aggressiveness. Cancer stem cells (CSCs) contribute to the tumorigenesis and metastasis of NSCLC. Hitherto, the mechanism by which YBX1 regulates CSCs and metastasis in N...

journal_title：Biochemical and biophysical research communications

authors： Guo T,Kong J,Liu Y,Li Z,Xia J,Zhang Y,Zhao S,Li F,Li J,Gu C

更新日期：2017-05-20 00:00:00

abstract：:The purpose of this investigation was to find out whether C-terminally end-cleaved aquaporin 0 (AQP0), that is present predominantly in the lens mature fiber cells of the WT, functions as a water channel and a cell-to-cell adhesion (CTCA) protein in a knockin (KI) mouse model (AQP0ΔC/ΔC) that does not express intact A...

journal_title：Biochemical and biophysical research communications

authors： Kumari SS,Varadaraj K

更新日期：2019-04-09 00:00:00

abstract：:Synthesis of the vasodilator nitric oxide (NO) can be inhibited by the endogenous methylarginines L-NMMA and ADMA. ADMA is elevated in a number of cardiovascular disorders in which NO availability is reduced. Elimination of ADMA from the body occurs primarily by enzymatic breakdown through the action of DDAH, of which...

journal_title：Biochemical and biophysical research communications

authors： Jones LC,Tran CT,Leiper JM,Hingorani AD,Vallance P

更新日期：2003-10-24 00:00:00

abstract：:In this study we identified a potential pro-apoptotic caspase gene, Bombyx mori(B. mori)ICE-2 (BmICE-2) which encoded a polypeptide of 284 amino acid residues, including a (169)QACRG(173) sequence which surrounded the catalytic site and contained a p20 and a p10 domain. BmICE-2 expressed in Escherichia coli (E. coli) ...

journal_title：Biochemical and biophysical research communications

authors： Yi HS,Pan CX,Pan C,Song J,Hu YF,Wang L,Pan MH,Lu C

更新日期：2014-02-28 00:00:00

abstract：:Firefly luciferase is inactivated by singlet oxygen at near diffusion controlled rates, 1.9 X 10(9) M-1 s-1, based on direct comparison with the oxidation of L-histidine. The inactivation kinetics are multiphasic. Inactivation is inhibitable by NaN3. Surface-separated-sensitizer (SSS) system in which singlet oxygen is...

journal_title：Biochemical and biophysical research communications

authors： Thompson A,Nigro J,Seliger HH

更新日期：1986-11-14 00:00:00

abstract：:CREB3 (Luman) is a family member of ER resident transcription factors, which are cleaved upon the induction of ER stress. Their N-terminal fragments shuttle into the nucleus where they regulate the transcription of target genes. Here, we found that human CREB3 is phosphorylated within its transcription activation doma...

journal_title：Biochemical and biophysical research communications

authors： Schmitt BM,Ampofo E,Stumpf H,Montenarh M,Götz C

更新日期：2020-03-12 00:00:00

abstract：:We report the results of a pilot study to determine the feasibility of using PCR random mutagenesis and in vitro transcription/translation to produce protease resistant full-length or truncated ovine prion proteins (PrP). Using this approach, we show the novel production of protease resistant recombinant ovine prion p...

journal_title：Biochemical and biophysical research communications

authors： Dear DV,Fitzmaurice TJ,Garton S,Richards SJ

更新日期：2001-03-09 00:00:00

abstract：:Partially purified preparations of O6-alkylguanine-DNA alkyltransferase from rat liver and E. coli were tested for their ability to repair O4-methylthymine in a methylated poly(dT) X poly(dA) substrate. The bacterial preparation readily carried out this reaction, but no loss of O4-methylthymine was obtained with the r...

journal_title：Biochemical and biophysical research communications

authors： Dolan ME,Scicchitano D,Singer B,Pegg AE

更新日期：1984-08-30 00:00:00

abstract：:Model-free approaches (error-prone PCR to introduce random mutations, DNA shuffling to combine positive mutations, and screening of the resultant mutant libraries) have been used to enhance the catalytic activity and thermostability of alpha-aspartyl dipeptidase from Salmonella typhimurium, which is uniquely able to h...

journal_title：Biochemical and biophysical research communications

authors： Kong X,Liu Y,Gou X,Zhu S,Zhang H,Wang X,Zhang J

更新日期：2001-11-23 00:00:00

abstract：:Natural Killer (NK) cells are highly mobile, specialized sub-populations of lymphocytic cells that survey their host to identify and eliminate infected or tumor cells. They are one of the key players in innate immunity and do not need prior activation through antigen recognition to deliver cytotoxic packages and relea...

journal_title：Biochemical and biophysical research communications

authors： Tompkins N,MacKenzie B,Ward C,Salgado D,Leidal A,McCormick C,Pohajdak B

更新日期：2014-08-22 00:00:00

abstract：:Tauroursodeoxycholic acid (TUDCA) is known to prevent apoptosis through the Bax pathway and to promote neovascularization by enhancing the mobilization of stem cells, their differentiation. This study was performed to investigate the effect of TUDCA on erythropoiesis in hematopoietic stem cells (HSCs). Since erythropo...

journal_title：Biochemical and biophysical research communications

authors： Hong SH,Yoon KJ,Lim KH,Um YJ,Cho JG,Jo YJ,Park SG

更新日期：2016-09-30 00:00:00

abstract：:Alveolar rhabdomyosarcoma (aRMS) is a very aggressive sarcoma of children and young adults. Our previous studies have shown that small molecule inhibition of Pdgfra is initially very effective in an aRMS mouse model. However, slowly evolving, acquired resistance to a narrow-spectrum kinase inhibitor (imatinib) was com...

journal_title：Biochemical and biophysical research communications

authors： Abraham J,Chua YX,Glover JM,Tyner JW,Loriaux MM,Kilcoyne A,Giles FJ,Nelon LD,Carew JS,Ouyang Y,Michalek JE,Pal R,Druker BJ,Rubin BP,Keller C

更新日期：2012-09-28 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) is detected in many aggressive tumors and involved in malignant conversion; however, the underlying mechanism remains obscure. Here, we identified PTHrP as a mediator of epidermal growth factor receptor (EGFR) signaling to promote the malignancies of oral cancers. PTHrP mRNA...

journal_title：Biochemical and biophysical research communications

authors： Yamada T,Tsuda M,Ohba Y,Kawaguchi H,Totsuka Y,Shindoh M

更新日期：2008-04-11 00:00:00

abstract：:The cytotoxicity of 1-methyl-4-phenylpyridinium (MPP+) is believed to arise as a consequence of its time- and energy-dependent accumulation inside mitochondria, followed by inhibition of electron transport at Complex I of the respiratory chain. Consistent with our proposal that the accumulation of MPP+ represents a pa...

journal_title：Biochemical and biophysical research communications

authors： Sayre LM,Wang F,Hoppel CL

更新日期：1989-06-15 00:00:00

abstract：:Mutations in the gene coding for connexin26 (Cx26) is the most common cause of human nonsyndromic hereditary deafness. To investigate deafness mechanisms underlying Cx26 null mutations, we generated three independent lines of conditional Cx26 null mice. Cell differentiation and gross cochlear morphology at birth seeme...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Chang Q,Tang W,Sun Y,Zhou B,Li H,Lin X

更新日期：2009-07-17 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is an endothelial cell specific mitogen that induces angiogenesis in several pathological conditions. To block angiogenesis, soluble VEGF receptor can be used. In this study, we describe a method for high yield expression of soluble VEGF receptor 2 (sFlk-1) in a baculovirus ex...

journal_title：Biochemical and biophysical research communications

authors： Huang X,Gottstein C,Brekken RA,Thorpe PE

更新日期：1998-11-27 00:00:00

abstract：:Recent structural investigations on the beta-1,4-galactosyltransferase-1 (Gal-T1) and lactose synthase (LS) have revealed that they are akin to an exquisite mechanical device with two well-coordinated flexible loops that are contained within the Gal-T1 catalytic domain. The smaller one has a Trp residue (Trp314) flank...

journal_title：Biochemical and biophysical research communications

authors： Ramakrishnan B,Boeggeman E,Qasba PK

更新日期：2002-03-15 00:00:00

abstract：:Increasing evidence has shown that miRNAs are implicated in carcinogenesis and can function as oncogenes or tumor suppressor genes in human cancers. In this study, we confirmed that miR-214 is frequently down-regulated in cervical cancer compared with normal cervical tissues. Ectopic expression of miR-214 suppressed p...

journal_title：Biochemical and biophysical research communications

authors： Peng R,Men J,Ma R,Wang Q,Wang Y,Sun Y,Ren J

更新日期：2017-03-11 00:00:00

abstract：:Synthesis of melanin starts from the conversion of L-tyrosine to 3,4-dihydroxyphenylalanine (L-dopa) and then the oxidation of L-dopa yields dopaquinone by tyrosinase. Therefore, tyrosinase inhibitors have been established as important constituents of depigmentation agents. Recently, polyhydroxystilbene compounds, whi...

journal_title：Biochemical and biophysical research communications

authors： Ohguchi K,Tanaka T,Kido T,Baba K,Iinuma M,Matsumoto K,Akao Y,Nozawa Y

更新日期：2003-08-08 00:00:00

abstract：:Cytoskeletal reorganization processes can be analyzed by studying the nanometer-scale spontaneous motion of beads bound to the cytoskeleton. The bead motion is determined by force fluctuations within the cytoskeletal network that originates from myosin motor activity and dynamic restructuring of cytoskeletal filaments...

journal_title：Biochemical and biophysical research communications

authors： Alonso JL,Goldmann WH

更新日期：2012-05-04 00:00:00

abstract：:A family of proteins, Homers 1, 2 and 3, involved in activity-dependent control of signal transduction has been recently described in neurons [Xiao, B., Tu, C. J., Petralia, R. S., Yuan, J. P., Doan, A., Breder, C. D., Ruggiero, A., Lanahan, A. A., Wenthold, R. J., and Worley, P. F. (1998) Homer regulates the associat...

journal_title：Biochemical and biophysical research communications

authors： Sandonà D,Tibaldo E,Volpe P

更新日期：2000-12-20 00:00:00

abstract：:Rat hearts were perfused for 15min with buffer equilibrated with 0.01% or 0.05% CO. The buffer was equilibrated with 21% O(2) throughout. The ventricular glutathione content decreased by 76% and 84%, 90min post-exposure to 0.01% and 0.05% CO, respectively, compared with 0% CO controls (0.45+/-0.01 micromol/g wet tissu...

journal_title：Biochemical and biophysical research communications

authors： Patel AP,John Moody A,Handy RD,Robert Sneyd J

更新日期：2003-03-07 00:00:00

abstract：:Recently, we have reported three monoclonal antibodies (mAbs) against purified human placental insulin-like growth factor (IGF)-I receptors. These antibodies, in contrast to the well-studied mAb alpha IR-3, stimulate binding of IGF-I and IGF-II to the receptor and DNA synthesis as well [Xiong, et al., Proc. Natl. Acad...

journal_title：Biochemical and biophysical research communications

authors： Li SL,Kato J,Paz IB,Kasuya J,Fujita-Yamaguchi Y

更新日期：1993-10-15 00:00:00

abstract：:Considering the number of cytosolic proteins associated with many diseases, development of cytosol-penetrating molecules from outside of living cells is highly in demand. To gain access to the cytosol after cellular uptake, cell-penetrating molecules should be released from intermediate endosomes prior to the lysosoma...

journal_title：Biochemical and biophysical research communications

authors： Kim JS,Choi DK,Park SW,Shin SM,Bae J,Kim DM,Yoo TH,Kim YS

更新日期：2015-11-27 00:00:00

abstract：:The hypothesis, that nucleic acids which code specifically interacting receptor and ligand proteins contain complementary sequences was tested. Human insulin mRNA (HSINSU) contained 16 sequences which were 23.8 +/- 1.4 nucleotides long and were complementary to the insulin receptor mRNA (HSIRPR, 74.8 +/- 1.9% compleme...

journal_title：Biochemical and biophysical research communications

authors： Segerstéen U,Nordgren H,Biro JC

更新日期：1986-08-29 00:00:00

abstract：:The activity of Cav1.2 Ca(2+) channels is maintained in the presence of calmodulin and ATP, even in cell-free patches, and thus a channel ATP-binding site has been suggested. In this study, we examined whether other nucleotides, such as GTP, UTP, CTP, ADP and AMP, could be substituted for ATP in guinea-pig ventricular...

journal_title：Biochemical and biophysical research communications

authors： Liu SY,Xu JJ,Minobe E,Gao QH,Feng R,Zhao MM,Guo F,Yang L,Hao LY,Kameyama M

更新日期：2015-05-08 00:00:00

abstract：:Recent evidence suggested that human cardiac stem cells (hCSCs) may have the clinical application for cardiac repair; however, their characteristics and the regulatory mechanisms of their growth have not been fully investigated. Here, we show the novel property of hCSCs with respect to their origin and tissue distribu...

journal_title：Biochemical and biophysical research communications

authors： Tateishi K,Ashihara E,Honsho S,Takehara N,Nomura T,Takahashi T,Ueyama T,Yamagishi M,Yaku H,Matsubara H,Oh H

更新日期：2007-01-19 00:00:00