The stability of CREB3/Luman is regulated by protein kinase CK2 phosphorylation.

Abstract:

:CREB3 (Luman) is a family member of ER resident transcription factors, which are cleaved upon the induction of ER stress. Their N-terminal fragments shuttle into the nucleus where they regulate the transcription of target genes. Here, we found that human CREB3 is phosphorylated within its transcription activation domain on serine 46 by protein kinase CK2. Further analyses revealed that the phosphorylation of this site does neither affect the cleavage by S1P/S2P proteases, nor the nuclear localisation nor the transcriptional activity of CREB3. However, phosphorylation at serine 46 reduced the stability of CREB3.

authors

Schmitt BM,Ampofo E,Stumpf H,Montenarh M,Götz C

doi

10.1016/j.bbrc.2019.12.118

subject

Has Abstract

pub_date

2020-03-12 00:00:00

pages

639-644

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(20)30076-0

journal_volume

523

pub_type

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