Abstract:
:CREB3 (Luman) is a family member of ER resident transcription factors, which are cleaved upon the induction of ER stress. Their N-terminal fragments shuttle into the nucleus where they regulate the transcription of target genes. Here, we found that human CREB3 is phosphorylated within its transcription activation domain on serine 46 by protein kinase CK2. Further analyses revealed that the phosphorylation of this site does neither affect the cleavage by S1P/S2P proteases, nor the nuclear localisation nor the transcriptional activity of CREB3. However, phosphorylation at serine 46 reduced the stability of CREB3.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Schmitt BM,Ampofo E,Stumpf H,Montenarh M,Götz Cdoi
10.1016/j.bbrc.2019.12.118subject
Has Abstractpub_date
2020-03-12 00:00:00pages
639-644issue
3eissn
0006-291Xissn
1090-2104pii
S0006-291X(20)30076-0journal_volume
523pub_type
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