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Human cardiac stem cells exhibit mesenchymal features and are maintained through Akt/GSK-3beta signaling.

Abstract：

:Recent evidence suggested that human cardiac stem cells (hCSCs) may have the clinical application for cardiac repair; however, their characteristics and the regulatory mechanisms of their growth have not been fully investigated. Here, we show the novel property of hCSCs with respect to their origin and tissue distribution in human heart, and demonstrate the signaling pathway that regulates their growth and survival. Telomerase-active hCSCs were predominantly present in the right atrium and outflow tract of the heart (infant > adult) and had a mesenchymal cell-like phenotype. These hCSCs expressed the embryonic stem cell markers and differentiated into cardiomyocytes to support cardiac function when transplanted them into ischemic myocardium. Inhibition of Akt pathway impaired the hCSC proliferation and induced apoptosis, whereas inhibition of glycogen synthase kinase-3 (GSK-3) enhanced their growth and survival. We conclude that hCSCs exhibit mesenchymal features and that Akt/GSK-3beta may be crucial modulators for hCSC maintenance in human heart.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Tateishi K,Ashihara E,Honsho S,Takehara N,Nomura T,Takahashi T,Ueyama T,Yamagishi M,Yaku H,Matsubara H,Oh H

doi

10.1016/j.bbrc.2006.11.096

subject

Has Abstract

pub_date

2007-01-19 00:00:00

pages

635-41

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)02531-9

journal_volume

352

pub_type

杂志文章

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