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AMP-activated protein kinase is essential for survival in chronic hypoxia.

Abstract：

:This study was undertaken to interrogate cancer cell survival during long-term hypoxic stress. Two systems with relevance to carcinogenesis were employed: Fully transformed BJ cells and a renal carcinoma cell line (786-0). The dynamic of AMPK activity was consistent with a prosurvival role during chronic hypoxia. This was further supported by the effects of AMPK agonists and antagonists (AICAR and compound C). Expression of a dominant-negative AMPK alpha resulted in a decreased ATP level and significantly compromised survival in hypoxia. Dose-dependent prosurvival effects of rapamycin were consistent with mTOR inhibition being a critical downstream mediator of AMPK in persistent low oxygen.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Borger DR,Gavrilescu LC,Bucur MC,Ivan M,Decaprio JA

doi

10.1016/j.bbrc.2008.03.056

subject

Has Abstract

pub_date

2008-05-30 00:00:00

pages

230-4

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)00526-3

journal_volume

370

pub_type

杂志文章

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