Abstract:
:Phospholipase C (PLC) has been known to be a key effector protein in signal transduction pathway for cell proliferation and differentiation. Here, we report the transcriptional regulation of PLC-gamma 1 during myogenic differentiation. Both PLC-gamma 1 mRNA and protein levels were increased during myogenesis. The activity of PLC-gamma 1 was also comparable to the amount estimated by Western blot. Comparing promoter activities of various PLC-gamma 1 gene upstream regions in myoblast and myotube, the responsible region was mapped between -551 and -480. From these results, we conclude that the transcription of PLC-gamma 1 is increased by the control of GPE1 region of PLC-gamma 1 gene during myogenesis.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Lee SJ,Lee YH,Kim YS,Ryu SH,Suh PGdoi
10.1006/bbrc.1995.1027subject
Has Abstractpub_date
1995-01-05 00:00:00pages
194-200issue
1eissn
0006-291Xissn
1090-2104pii
S0006-291X(85)71027-3journal_volume
206pub_type
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journal_title:Biochemical and biophysical research communications
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