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Intronic sequences are involved in neural targeting of human dopamine transporter gene expression.

Abstract：

:Dopamine transporter (DAT) plays a key role in terminating synaptic dopaminergic transmission. DAT acts exclusively on the plasma membrane of presynaptic dopaminergic neurons and DAT gene is an appropriate model for the study of dopaminergic neuron-specific regulation of gene activity. DAT represents an important target for widely used neuroleptic drugs and psychostimulants and for catecholamine-selective neurotoxins. Functional abnormalities of DAT have been implicated in diverse neurologic and psychiatric disorders. Understanding the mechanisms regulating human DAT gene activity is an important step towards elucidation of the molecular bases of a number of disorders and psychostimulant drug abuse and dependence. In this study we have cloned and characterised a 7-kb segment of the human DAT gene which includes at least 4 kb of its 5'-flanking region, localised its essential, or core-promoter, and identified the region involved in regulation of DAT neurospecific expression.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kouzmenko AP,Pereira AM,Singh BS

doi

10.1006/bbrc.1997.7754

subject

Has Abstract

pub_date

1997-11-26 00:00:00

pages

807-11

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(97)97754-8

journal_volume

240

pub_type

杂志文章

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