The Eλ(3-1) enhancer is essential for V(D)J recombination of the murine immunoglobulin lambda light chain locus.

abstract：:CCG-1423, a chemical inhibitor of Rho signaling, blocks serum response factor (SRF)/megakaryoblastic leukemia 1 (MKL1)-mediated gene expression by inhibiting the nuclear accumulation of MKL1. Several studies have suggested that CCG-1423 interacts not only with MKL1, which has a critical role in the regulation of neuro...

journal_title：Biochemical and biophysical research communications

authors： Kikuchi K,Shiota J,Yamada T,Ishikawa M,Ihara D,Fukuchi M,Tsuda M,Tabuchi A

更新日期：2017-10-21 00:00:00

abstract：:Interleukin (IL)-33 is a novel member of the IL-1 family. IL-33 is primarily synthesized as a 30-kDa precursor (pro-IL-33). Pro-IL-33 is cleaved by caspase-1 into an 18-kDa mature form (mature IL-33) in vitro. Recombinant mature IL-33 has been known to induce T-helper type-2 (Th2)-associated cytokines and inflammatory...

journal_title：Biochemical and biophysical research communications

authors： Hayakawa M,Hayakawa H,Matsuyama Y,Tamemoto H,Okazaki H,Tominaga S

更新日期：2009-09-11 00:00:00

abstract：:A GSH-dependent dehydroascorbate reductase (EC 1.8.5.1) was purified to homogeneity from human erythrocytes. The enzyme was a monomer of 32 kDa and was purified 133-fold from a crude DEAE-Sepharose fraction with a 25% yield. The reduced protein had a pI of 5.1 as judged by isoelectric focusing. Kinetic analysis gave a...

journal_title：Biochemical and biophysical research communications

authors： Xu DP,Washburn MP,Sun GP,Wells WW

更新日期：1996-04-05 00:00:00

abstract：:The interest in adiponutrin stems from adiponutrin variant I148M, which is strongly associated to non-alcoholic fatty liver disease. Adiponutrin has to date been considered to be solely an intracellular protein, with a role in lipid metabolism in liver and adipose tissue. However, a physiologically relevant role for a...

journal_title：Biochemical and biophysical research communications

authors： Winberg ME,Motlagh MK,Stenkula KG,Holm C,Jones HA

更新日期：2014-04-18 00:00:00

abstract：:Mammary gland-distributed and ER-bound UDP-glucuronosyltransferase (UGT)-2B7 metabolizes genotoxic catechol-estrogens (CE) associated with breast cancer initiation. Although UGT2B7 has 3 PKC- and 2 tyrosine kinase (TK)-sites, its inhibition by genistein, herbimycin-A and PP2 with parallel losses in phospho-tyrosine an...

journal_title：Biochemical and biophysical research communications

authors： Mitra PS,Basu NK,Owens IS

更新日期：2009-05-15 00:00:00

abstract：:We have recently shown that optimal growth temperature (T(opt)) is one of the factors that influence genomic GC in prokaryotes. Our results have been disputed by Marashi and Ghalanbor, who claim that the correlations we show are not "robust" because the elimination of some points (arbitrarily chosen) leads, in some fa...

journal_title：Biochemical and biophysical research communications

authors： Musto H,Naya H,Zavala A,Romero H,Alvarez-Valin F,Bernardi G

更新日期：2005-05-06 00:00:00

abstract：:Genes are organized as chromatin domains and positioned in the nucleus through regions of nuclear matrix association, termed MARs. Although well-studied, the mechanisms regulating expression of the beta-globin locus remain an enigma. Here, we show that certain MAR sequences of the beta-globin locus are conserved and r...

journal_title：Biochemical and biophysical research communications

authors： Walter WR,Singh GB,Krawetz SA

更新日期：1998-01-14 00:00:00

abstract：:In spite of intensive research, our understanding of the regulation of expression of 5-LO (the key enzyme in the leukotriene metabolism) remains fragmentary. We investigated the effects of dexamethasone on the expression of this gene in a binary model consisting of two clones of the human mast cell line HMC-1, one wit...

journal_title：Biochemical and biophysical research communications

authors： Colamorea T,Di Paola R,Macchia F,Guerrese MC,Tursi A,Butterfield JH,Caiaffa MF,Haeggström JZ,Macchia L

更新日期：1999-11-30 00:00:00

abstract：:A general method to obtain the variable region DNA sequence of the immunoglobulin heavy chain using anchored polymerase chain reaction is described. Based on this DNA sequence, clone-specific oligonucleotides were designed to anneal to the complementarity determining regions. These were used to identify the original B...

journal_title：Biochemical and biophysical research communications

authors： Ratech H

更新日期：1992-02-14 00:00:00

abstract：:The effects of heparin (180 micrograms/ml) on steady state mRNA levels for fibronectin, thrombospondin, actin and collagen types I and III were investigated in human umbilical artery smooth muscle cells. Heparin caused a 120% increase in thrombospondin mRNA levels and a 60% and 180% increase in the mRNA levels of proc...

journal_title：Biochemical and biophysical research communications

authors： Lyons-Giordano B,Brinker JM,Kefalides NA

更新日期：1989-08-15 00:00:00

abstract：:Phosphatases play an important role in cellular signaling and are often found dysregulated in cancers including glioblastoma (GBM). A comprehensive bioinformatics analysis of phosphatases (n = 403) in multiple datasets revealed their deregulation in GBM. Among the differentially regulated phosphatases (n = 186; 46.1%)...

journal_title：Biochemical and biophysical research communications

authors： Tomar VS,Baral TK,Nagavelu K,Somasundaram K

更新日期：2019-07-12 00:00:00

abstract：:TANC1 and its close relative TANC2 are two important synaptic scaffold proteins which play critical roles in regulating densities of synaptic spines and excitatory synapse strength. Recent studies indicated TANC1 and TANC2 are candidate genes of several neurodevelopmental disorders (NDD). So far, the biochemical prope...

journal_title：Biochemical and biophysical research communications

authors： Yang Q,Liu H,Li Z,Wang Y,Liu W

更新日期：2019-06-25 00:00:00

abstract：:Diabetes mellitus (DM) is a risk factor for abnormal heart development, but the molecular mechanism remains obscure. Histone deacetylase 11 (HDAC11), the most recently identified histone deacetylase, is the sole member of class IV HDACs. However, its role in diabetic cardiac injury is still poorly understood. In the p...

journal_title：Biochemical and biophysical research communications

authors： Fan XD,Wan LL,Duan M,Lu S

更新日期：2018-09-05 00:00:00

abstract：:Clinical attention to gluten-related disorders, such as celiac disease and nonceliac gluten sensitivity, is on the rise. However, identifying the pathophysiological mechanisms of gluten-related disorders remains elusive. Gliadin, a component of gluten, is known to play a major role in gluten toxicity. Caenorhabditis e...

journal_title：Biochemical and biophysical research communications

authors： Lim SD,Min H,Youn E,Kawasaki I,Shim YH

更新日期：2018-09-10 00:00:00

abstract：:The effect of steroid chemical structure on steroid-lipid interaction is studied in sonicated dipalmitoyl phosphatidylcholine vesicles by steady-state and time-resolved fluorescence anisotropy techniques using diphenylhexatriene as probe. A large number of cholesterol derivatives and steroids, some of them being precu...

journal_title：Biochemical and biophysical research communications

authors： Vincent M,Gallay J

更新日期：1983-06-29 00:00:00

abstract：:The amino acid sequence of full-length ovine fibroblast growth factor-1 (FGF-1) was determined by a combination of protein and cDNA sequencing. FGF-1 cDNA analysis indicated that ovine kidney cells express mRNAs encoding both full-length FGF-1 and a truncated FGF-1 variant. An overall comparison of the ovine FGF-1 pri...

journal_title：Biochemical and biophysical research communications

authors： Grieb TW,Ring M,Brown E,Palmer C,Belle N,Donjerkovic D,Chang H,Yun J,Subramanian R,Forozan F,Guo Y,Vertes A,Winkles JA,Burgess WH

更新日期：1998-05-08 00:00:00

abstract：:Uncoupling proteins (UCPs) are mitochondrial membrane proton transporters that uncouple oxidative phosphorylation by dissipating the proton gradient across the membrane. We have investigated regulation of the UCP3 gene in skeletal muscle and C2C12 muscle cells. UCP3 mRNA in mouse skeletal muscle is markedly increased ...

journal_title：Biochemical and biophysical research communications

authors： Hwang CS,Lane MD

更新日期：1999-05-10 00:00:00

abstract：:The alternatively spliced isoform of the nonmuscle myosin II heavy chain B (MHC-B) with an insert of 21 amino acids at the 50- to 20-kDa junction of the globular region of myosin has been demonstrated to be expressed specifically in the central nervous system (CNS) in chicken. To explore the role of this B2 inserted i...

journal_title：Biochemical and biophysical research communications

authors： Takahashi M,Hirano T,Uchida K,Yamagishi A

更新日期：1999-05-27 00:00:00

abstract：:Low-molecular-weight metabolites in human milk are gaining increasing interest in studies of infant nutrition. In the present study, the milk metabolome from a single mother was explored at different stages of lactation. Metabolites were extracted from sample aliquots using either methanol/water (MeOH/H2O) extraction ...

journal_title：Biochemical and biophysical research communications

authors： Wu J,Domellöf M,Zivkovic AM,Larsson G,Öhman A,Nording ML

更新日期：2016-01-15 00:00:00

abstract：:The Fragile X protein FMRP is an RNA binding protein whose targets are not well known; yet, these RNAs may play an integral role in the disease's etiology. Using a biotinylated-FMRP affinity resin, we isolated RNAs from the parietal cortex of a normal adult that bound FMRP. These RNAs were amplified by differential di...

journal_title：Biochemical and biophysical research communications

authors： Sung YJ,Conti J,Currie JR,Brown WT,Denman RB

更新日期：2000-09-07 00:00:00

abstract：:Two common non-steroidal anti-inflammatory drugs (NSAIDs) and their nitric oxide (NO) adducts were evaluated for effects on stomach and thymus. Following 4-h duration (acute) oral dosing of fasted male Wistar rats, 1.33 x 10(-4)mol/kg of ibuprofen caused significant visual irritation score and microscopic thinning, al...

journal_title：Biochemical and biophysical research communications

authors： Downing JE,Madden JC,Ingram MJ,Rostron C

更新日期：2005-08-26 00:00:00

abstract：:Treatment of RGCs with insulin or C2 ceramide alone increased survival rate by 30%. Adding both insulin and C2 ceramide increased survival rate by 80%. Protein phosphatase 2A (PP2A) inhibitor okadaic acid (OA) eliminated the effect of C2 ceramide, but not that of insulin. Protein kinase inhibitor K252a decreased the e...

journal_title：Biochemical and biophysical research communications

authors： Ito M

更新日期：2003-02-07 00:00:00

abstract：:The effects of the serine/threonine phosphatase inhibitors calyculin A, okadaic acid and the calmodulin antagonist W-7 on amylase secretion were studied in pancreatic acini. Calyculin A and okadaic acid dose-dependently inhibited amylase secretion to basal levels when stimulated with the intracellularly acting secreta...

journal_title：Biochemical and biophysical research communications

authors： Meyer-Alber A,Fetz I,Waschulewski IH,Höcker M,Fölsch UR,Schmidt WE

更新日期：1994-06-30 00:00:00

abstract：:Human monomorphic and polymorphic arylamine acetyltransferases (EC 2.3.1.5) were expressed in monkey kidney COS-1 cells and used to study the N- and O-acetylation of a number of carcinogenic amines and their N-hydroxy metabolites. The monomorphic enzyme N-acetylated the aromatic amines, 2-aminofluorene and 4-aminobiph...

journal_title：Biochemical and biophysical research communications

authors： Minchin RF,Reeves PT,Teitel CH,McManus ME,Mojarrabi B,Ilett KF,Kadlubar FF

更新日期：1992-06-30 00:00:00

abstract：:Expression of ALP in F9 teratocarcinoma cells is induced by all-trans retinoic acid (ATRA) (Gianni' et al., Biochem. J. 274: 673-678, 1991). The specific ligand for retinoic acid related receptors (RXRs), 9-cis retinoic acid (9-cis RA), and three synthetic analogs binding to the alpha, beta and gamma forms of the reti...

journal_title：Biochemical and biophysical research communications

authors： Gianni M,Zanotta S,Terao M,Garattini S,Garattini E

更新日期：1993-10-15 00:00:00

abstract：:Recently, increasing evidences demonstrate that circular RNAs (circRNAs) exert very important functions in the progression of human cancers. However, the functions and molecular mechanism of circ_0067934 in hepatocellular carcinoma (HCC) are largely unknown. In the present study, we found that the expression of circ_0...

journal_title：Biochemical and biophysical research communications

authors： Zhu Q,Lu G,Luo Z,Gui F,Wu J,Zhang D,Ni Y

更新日期：2018-03-04 00:00:00

abstract：:Erythropoietin (EPO) stimulates the production of small erythroid cell stimulating factors (molecular weight <5 kDa) in cultures of bone marrow endothelial cells. We identified a fragment of thrombospondin-4 (TSP-4) as an EPO-stimulated protein in endothelial cell lysates. Pre-incubation of the low molecular weight fr...

journal_title：Biochemical and biophysical research communications

authors： Congote LF,Difalco MR,Gibbs BF

更新日期：2004-11-12 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) is produced by various normal and neoplastic tissues. Even if the physiological function(s) of PTHrP is unclear, evidence suggests that the protein may participate in the local regulation of smooth muscle contractility. We show here that PTHrP is produced in endothelial cell...

journal_title：Biochemical and biophysical research communications

authors： Rian E,Jemtland R,Olstad OK,Endresen MJ,Grasser WA,Thiede MA,Henriksen T,Bucht E,Gautvik KM

更新日期：1994-01-28 00:00:00

abstract：:Reactions of Paracoccus halodenitrificans nitric oxide reductase (NOR) containing four iron centers, a low spin hemec, a low spin heme b, a high spin heme b and a non-heme iron, have been studied to show the roles of each iron center. Soon after reacting the resting (oxidized) NOR with L-ascorbate, the low spin heme c...

journal_title：Biochemical and biophysical research communications

authors： Sakurai T,Sakurai N,Matsumoto H,Hirota S,Yamauchi O

更新日期：1998-10-09 00:00:00

abstract：:Near infrared spectroscopy with aquaphotomics as a novel approach was assessed for the diagnosis of soybean plants (Glycine max) infected with soybean mosaic virus (SMV) at latent symptomless stage of the disease. Near infrared (NIR) leaf spectra (in the range of 730-1025nm) acquired from soybean plants with and witho...

journal_title：Biochemical and biophysical research communications

authors： Jinendra B,Tamaki K,Kuroki S,Vassileva M,Yoshida S,Tsenkova R

更新日期：2010-07-09 00:00:00