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RNAs that interact with the fragile X syndrome RNA binding protein FMRP.

Abstract：

:The Fragile X protein FMRP is an RNA binding protein whose targets are not well known; yet, these RNAs may play an integral role in the disease's etiology. Using a biotinylated-FMRP affinity resin, we isolated RNAs from the parietal cortex of a normal adult that bound FMRP. These RNAs were amplified by differential display (DDRT-PCR) and cloned and their identities determined. Nine candidate RNAs were isolated; five RNAs, including FMR1 mRNA, encoded known proteins. Four others were novel. The specificity of binding was demonstrated for each candidate RNA. The domains required for binding a subset of the RNAs were delineated using FMRP truncation mutant proteins and it was shown that only the KH2 domain was required for binding. Binding occurred independently of homoribopolymer binding to the C-terminal arginine-glycine-rich region (RGG box), suggesting that FMRP may bind multiple RNAs simultaneously.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sung YJ,Conti J,Currie JR,Brown WT,Denman RB

doi

10.1006/bbrc.2000.3405

subject

Has Abstract

pub_date

2000-09-07 00:00:00

pages

973-80

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(00)93405-3

journal_volume

275

pub_type

杂志文章

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