HDAC11 deletion reduces fructose-induced cardiac dyslipidemia, apoptosis and inflammation by attenuating oxidative stress injury.

abstract：:At high dietary levels in vivo, both 13-cis-retinoic acid and calcium glucarate inhibit the induction of rat mammary tumors by 7,12-dimethylbenz(a)anthracene. The present study shows that sub-optimal dietary levels of each, which individually have no effect on tumor induction, when combined together in the diet, signi...

journal_title：Biochemical and biophysical research communications

authors： Abou-Issa H,Koolemans-Beynen A,Minton JP,Webb TE

更新日期：1989-09-29 00:00:00

abstract：:Studies have shown similarities between the histopathological characteristics of NPC and Alzheimer's disease (AD) including amyloid and tau pathologies. While dysfunction in insulin signaling was widely detected in AD brain, the function of insulin signaling proteins has not been examined in NPC disease. In this study...

journal_title：Biochemical and biophysical research communications

authors： Ong QR,Lim ML,Chua CC,Cheung NS,Wong BS

更新日期：2012-08-03 00:00:00

abstract：:Gut microbiota is critical for maintaining body immune homeostasis and thus affects tumor growth and therapeutic efficiency. Here, we investigated the link between microbiota and tumorgenesis in a mice model of subcutaneous melanoma cell transplantation, and explored the underlying mechanism. We found disruption of gu...

journal_title：Biochemical and biophysical research communications

authors： Xu C,Ruan B,Jiang Y,Xue T,Wang Z,Lu H,Wei M,Wang S,Ye Z,Zhai D,Wang L,Lu Z

更新日期：2017-06-24 00:00:00

abstract：:Conditioned media (CM) from various marrow subpopulations (MBA series) were examined for their effects on growth and maturation of marrow-derived osteoblastic cells, MBA-15. CM harvested from a stromal adipocytes, 14F1.1, stimulated cell growth, collagen but not non-collagenous proteins synthesized by MBA-15 cells. Al...

journal_title：Biochemical and biophysical research communications

authors： Benayahu D,Zipori D,Wientroub S

更新日期：1993-12-30 00:00:00

abstract：:Epimorphin, a mesenchymal cell surface-associated molecule, is detected on hepatic stellate cells (HSCs) in the liver. Here, we show the involvement of epimorphin in differentiation of rat hepatic stem-like cells (HSLCs) through contact with HSCs. HSLCs, isolated from adult rats, cultured in stellate cell-conditioned ...

journal_title：Biochemical and biophysical research communications

authors： Miura K,Nagai H,Ueno Y,Goto T,Mikami K,Nakane K,Yoneyama K,Watanabe D,Terada K,Sugiyama T,Imai K,Senoo H,Watanabe S

更新日期：2003-11-14 00:00:00

abstract：:Binding of N-formylated chemotactic peptides to specific cell surface receptors on polymorphonuclear leukocytes initiates a wide range of biological responses including migration of inflammatory cells, superoxide release, lysosomal enzyme secretion, calcium mobilization, and cellular activation. We previously establis...

journal_title：Biochemical and biophysical research communications

authors： Shawar SM,Rich RR,Becker EL

更新日期：1995-06-26 00:00:00

abstract：:We examined the effects of troglitazone on expression of E-cadherin and claudin 4 in human pancreatic cancer cells. Troglitazone dose-dependently increased expression of E-cadherin and claudin 4 mRNA and protein in PK-1 cells. Snail, Slug and ZEB1, mRNAs were not changed by troglitazone, indicating that these three tr...

journal_title：Biochemical and biophysical research communications

authors： Kumei S,Motomura W,Yoshizaki T,Takakusaki K,Okumura T

更新日期：2009-03-13 00:00:00

abstract：:The sarcoplasmic potassium concentration of a suspension of rat ventricular myocytes, prepared by collagenase-induced disruption of the myocardial mass, was determined by a null-point technique. Addition of digitonin resulted in a release of potassium from the cells which was interpreted as a flux from the sarcoplasm....

journal_title：Biochemical and biophysical research communications

authors： Fry CH,Ward JP,Twist VW,Powell T

更新日期：1986-05-29 00:00:00

abstract：:We present here the biosynthesis of AgNps from the aqueous extract of H. thebaica fruit, and monitored through UV-Vis spectrophotometer. The functional group were characterized through ATR-FTIR spectroscopy, the particle size, morphologies and elemental composition of the nanoparticles were investigated by using TEM, ...

journal_title：Biochemical and biophysical research communications

authors： Bello BA,Khan SA,Khan JA,Syed FQ,Mirza MB,Shah L,Khan SB

更新日期：2017-08-26 00:00:00

abstract：:tsBN75 and tsBN423 are independently isolated temperature-sensitive (ts) mutants of the BHK21 cell line for cell growth. Both tsBN75 and tsBN423 belong to the same complementation group and show G2 block at the nonpermissive temperature. Both were efficiently transformed to ts+ cells with the mouse and human cDNA enco...

journal_title：Biochemical and biophysical research communications

authors： Nishitani H,Goto H,Kaneda S,Yamao F,Seno T,Handley P,Schwartz AL,Nishimoto T

更新日期：1992-04-30 00:00:00

abstract：:The endoplasmic reticulum (ER) is an organelle in which most membrane and secretory proteins are synthesized. If these proteins are not folded correctly, unfolded proteins accumulate in the ER lumen, causing a cellular situation known as ER stress. Recently, many studies on the relationship between ER stress and disea...

journal_title：Biochemical and biophysical research communications

authors： Hosoda A,Maruyama A,Oikawa D,Oshima Y,Komachi Y,Kanai G,Sato H,Iwawaki T

更新日期：2011-02-04 00:00:00

abstract：:Resolvin E1 (RvE1; 5S, 12R, 18R-trihydroxyeicosapentaenoic acid) is an anti-inflammatory lipid mediator derived from the omega-3 fatty acid eicosapentaenoic acid (EPA). It has been recently shown that RvE1 is involved in the resolution of inflammation. However, it is not known whether RvE1 is involved in the resolutio...

journal_title：Biochemical and biophysical research communications

authors： Aoki H,Hisada T,Ishizuka T,Utsugi M,Kawata T,Shimizu Y,Okajima F,Dobashi K,Mori M

更新日期：2008-03-07 00:00:00

abstract：:Rett syndrome is a neurodevelopmental disorder caused by Mecp2 gene mutations. In RTT patients and Mecp2-null (Mecp2(-/Y)) mice, norepinephrine (NE) content drops significantly, which may play a role in breathing arrhythmia, sleep disorders and sudden death. However, the underlying mechanisms for the NE defect are not...

journal_title：Biochemical and biophysical research communications

authors： Zhang X,Su J,Rojas A,Jiang C

更新日期：2010-04-02 00:00:00

abstract：:ABCG2 (also called MXR (3), BCRP (4), or ABCP (5) is a recently-identified ABC half-transporter, which causes multidrug resistance in cancer. Here we report that the expression of the ABCG2 protein in Sf9 insect cells resulted in a high-capacity, vanadate-sensitive ATPase activity in isolated membrane preparations. AB...

journal_title：Biochemical and biophysical research communications

authors： Ozvegy C,Litman T,Szakács G,Nagy Z,Bates S,Váradi A,Sarkadi B

更新日期：2001-07-06 00:00:00

abstract：:Colorectal cancer is a major contributor of cancer-related mortality. The mammalian target or rapamycin (mTOR) signaling is frequently hyper-activated in colorectal cancers, promoting cancer progression and chemo-resistance. In the current study, we investigated the anti-colorectal cancer effect of a novel mTOR comple...

journal_title：Biochemical and biophysical research communications

authors： Huo HZ,Zhou ZY,Wang B,Qin J,Liu WY,Gu Y

更新日期：2014-01-10 00:00:00

abstract：:Parathymosin has been purified from calf liver and its primary sequence established, except for a segment containing approximately 11 amino acid residues in the central part of the polypeptide chain. Bovine parathymosin contains approximately 101 amino acid residues and shows 90% identity with rat parathymosin, with s...

journal_title：Biochemical and biophysical research communications

authors： Panneerselvam C,Clinton M,Wellner D,Horecker BL

更新日期：1988-09-15 00:00:00

abstract：:The I domains of CD11 are responsible for the binding of ligands and have a unique structure with 6-7 alpha helices and 6 beta sheets with interconnecting loops. To determine loops recognizing fibrinogen in CD11c I domain, five oligopeptides corresponding to CD11c loops were used to prevent fibrinogen binding to isola...

journal_title：Biochemical and biophysical research communications

authors： Choi J,Nham SU

更新日期：2002-04-05 00:00:00

abstract：:Histone deacetylase 6 (HDAC6) controls acetylation of a number of cytosolic proteins, most prominently tubulin. Tubacin is a small molecule inhibitor of HDAC6 selected for its selective inhibition of HDAC6 relative to other histone deacetylases. For this reason it has become a useful pharmacological tool to discern th...

journal_title：Biochemical and biophysical research communications

authors： Siow D,Wattenberg B

更新日期：2014-07-04 00:00:00

abstract：:We have recorded multi-frequency EPR spectra of 63Cu- and 65Cu-labeled, water-soluble CuA-protein from the cytochrome ba3 of T. thermophilus. The spectrum taken at the highest frequency (34.03 GHz) shows no hyperfine structure and is nominally axial with apparent gz approximately 2.18 and gxy approximately 2.00. The s...

journal_title：Biochemical and biophysical research communications

authors： Fee JA,Sanders D,Slutter CE,Doan PE,Aasa R,Karpefors M,Vänngård T

更新日期：1995-07-06 00:00:00

abstract：:Leucine-rich repeat kinase 2 (LRRK2) is the causal gene for autosomal dominant familial Parkinson's disease. We have previously reported a novel molecular feature characteristic to I2020T mutant LRRK2: higher susceptibility to post-translational degradation than the wild-type LRRK2. In the present study, we demonstrat...

journal_title：Biochemical and biophysical research communications

authors： Ohta E,Kubo M,Obata F

更新日期：2010-01-01 00:00:00

abstract：:We have recently reported that Rootletin prevents Cep68 from VHL-mediated proteasomal degradation to maintain centrosome cohesion, unveiling the first underlying mechanism of a linker protein required for maintenance of centrosome cohesion. The minichromosome maintenance (MCM) proteins 2-7 have long been noticed to lo...

journal_title：Biochemical and biophysical research communications

authors： Kong L,Yin H,Yuan L

更新日期：2017-08-05 00:00:00

abstract：:The effect of various differentiation-inducers on the activity of Ca2+, phospholipid-dependent protein kinase (C-kinase) activity and endogenous protein phosphorylation by the kinase were examined in the extracts of HL-60 cells. Although all of the inducers, retinoic acid, dibutyryl cAMP, nicotinamide, dimethylsulfoxi...

journal_title：Biochemical and biophysical research communications

authors： Tanaka Y,Tsuyuki M,Itaya-Hironaka A,Inada Y,Yoshihara K,Kamiya T

更新日期：1990-05-16 00:00:00

abstract：:Estrogen depletion causes postmenopausal osteoporosis. Here we report that steady state mRNA levels of transforming growth factor-beta 1 (TGF-beta 1) and osteocalcin in bone persistently decreased and increased, respectively, in vivo in estrogen-depleted rats after ovariectomy (OVX). 21 female Wistar rats (7-month-old...

journal_title：Biochemical and biophysical research communications

authors： Ikeda T,Shigeno C,Kasai R,Kohno H,Ohta S,Okumura H,Konishi J,Yamamuro T

更新日期：1993-08-16 00:00:00

abstract：:BALB/c mice were immunized with rIGF-II receptors purified from 18-54, SF cells by chromatography of solubilized receptors over agarose-immobilized rIGF-II. Two fusions of splenic lymphocytes with FO mouse myeloma cells yielded 27 stable hybrids which were positive by ELISA. Cloning of seven of these hybrids yielded 3...

journal_title：Biochemical and biophysical research communications

authors： Rosenfeld RG,Pham H

更新日期：1987-07-31 00:00:00

abstract：:We investigated the regulation of Hsp27 phosphorylation by protein kinase C δ (PKCδ) during etoposide-induced apoptosis. The phosphorylation of Hsp27 at Ser78 was temporally correlated with the proteolytic activation of PKCδ during apoptosis. Hsp27 phosphorylation was dependent on the activity of PKCδ since treatment ...

journal_title：Biochemical and biophysical research communications

authors： Choi JS,Oh JI,Na M,Lee SK,Joo SH

更新日期：2012-10-05 00:00:00

abstract：:A high incidence of oncogenic K-ras mutations is observed in lung adenocarcinoma of human cases and carcinogen-induced animal models. The process of oncogenic K-ras-mediated lung adenocarcinogenesis can be dissected into two parts: pre- and post-K-ras mutation. Adoption of transgenic lines containing a flox-K-rasG12V ...

journal_title：Biochemical and biophysical research communications

authors： Saito H,Suzuki N

更新日期：2014-10-03 00:00:00

abstract：:We constructed a system for expressing the Fab of the therapeutic human monoclonal antibody adalimumab at a yield of 20 mg/L in the methylotrophic yeast Pichia pastoris. To examine the contribution of interchain disulfide bonds to conformational stability, we prepared adalimumab Fab from which the interchain disulfide...

journal_title：Biochemical and biophysical research communications

authors： Nakamura H,Oda-Ueda N,Ueda T,Ohkuri T

更新日期：2018-01-01 00:00:00

abstract：:Multidrug-resistant cells are characterized by the presence of P-glycoprotein on the plasma membrane, which binds and probably transports antitumor agents outside the cells. P-glycoprotein is also present in various normal tissues such as the adrenal gland. To investigate the physiological function of P-glycoprotein, ...

journal_title：Biochemical and biophysical research communications

authors： Naito M,Yusa K,Tsuruo T

更新日期：1989-02-15 00:00:00

abstract：:EAG1 channels belong to the KCNH family of voltage gated potassium channels. They are expressed in several brain regions and increased expression is linked to certain cancer types. Recent cryo-EM structure determination finally revealed the structure of these channels in atomic detail, allowing computational investiga...

journal_title：Biochemical and biophysical research communications

authors： Bernsteiner H,Bründl M,Stary-Weinzinger A

更新日期：2017-02-26 00:00:00

abstract：:Researchers frequently use 3T3-L1 adipocytes as a fat cell line, but the capacity of this line for insulin-mediated glucose transport is lower than that of primary isolated fat cells. In this study, we found that 5-azacytidine (5-aza-C), DNA methyltransferase 1 inhibitor, enhanced insulin-stimulated 2-deoxyglucose (2-...

journal_title：Biochemical and biophysical research communications

authors： Kuroda M,Onoyama R,Sasaki W,Sebe M,Kitamura T,Masumoto S,Tsutsumi R,Harada N,Sakaue H

更新日期：2020-02-16 00:00:00